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Volume 18 (15); 2022

Research Papers

Serological responses to human virome define clinical outcomes of Italian patients infected with SARS-CoV-2
Limin Wang, Julián Candia, Lichun Ma, Yongmei Zhao, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Kerry Dobbs, Peter D. Burbelo, Jeffrey I. Cohen, Ottavia M. Delmonte, Marshonna Forgues, Hui Liu, Helen F. Matthews, Elana Shaw, Michael A. Stack, Sarah E. Weber, Yu Zhang, Andrea Lisco, Irini Sereti, Helen C. Su, Luigi D. Notarangelo, Xin Wei Wang
Int. J. Biol. Sci. 2022; 18(15): 5591-5606. doi:10.7150/ijbs.78002
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease
Feng Liu, Jing Huang, Chunyun Zhang, Yaru Xie, Yiling Cao, Li Tao, Hui Tang, Jihong Lin, Hans-Peter Hammes, Kun Huang, Fan Yi, Hua Su, Chun Zhang
Int. J. Biol. Sci. 2022; 18(15): 5624-5640. doi:10.7150/ijbs.75994
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19
Bowu Chen, Peihua Geng, Jiaojiao Shen, Suthat Liangpunsakul, Hua Lyu, Jue Zhang, Yanbing Yang, Lei Zhang, Yuping Xu, Chunling Dong, Yanping Wang, Yan Xue, Wei Zhang, Hua Liu, Man Li, Yueqiu Gao
Int. J. Biol. Sci. 2022; 18(15): 5641-5652. doi:10.7150/ijbs.76699
[Abstract] [Full text] [PDF] [PubMed] [PMC]

TMP195 Exerts Antitumor Effects on Colorectal Cancer by Promoting M1 Macrophages Polarization
Yicheng Han, Jiachun Sun, Yanyan Yang, Yunlong Liu, Jun Lou, Hongming Pan, Junlin Yao, Weidong Han
Int. J. Biol. Sci. 2022; 18(15): 5653-5666. doi:10.7150/ijbs.73264
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Identification of Gαi3 as a novel molecular therapeutic target of cervical cancer
Jie Zhang, De-pei Yin, Yan Zhang, Jia-nan Zhang, Yan Yang, Zhi-qing Zhang, Li Zhou, Yan Lv, Hai-wei Huang, Cong Cao
Int. J. Biol. Sci. 2022; 18(15): 5667-5680. doi:10.7150/ijbs.77126
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β
Liping You, Jiacheng Lin, Zhuo Yu, Yihan Qian, Yuting Bi, Fang Wang, Lei Zhang, Chao Zheng, Jinghao Zhang, Wenxuan Li, Yaxuan Cai, Yueqiu Gao, Xiaoni Kong, Xuehua Sun
Int. J. Biol. Sci. 2022; 18(15): 5698-5712. doi:10.7150/ijbs.78345
[Abstract] [Full text] [PDF] [PubMed] [PMC]

HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation
Ya Gao, Yangdan Liu, Danning Zheng, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang
Int. J. Biol. Sci. 2022; 18(15): 5724-5739. doi:10.7150/ijbs.76140
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid
Liang Huang, Qichao Liao, Tingli Pan, Yu Sun, Zhier Aluo, Lianggui Xiao, Jingsu Yu, Siqi Liu, Yang Xiao, Yufeng Yang, Yixing Li, Lei Zhou
Int. J. Biol. Sci. 2022; 18(15): 5740-5752. doi:10.7150/ijbs.74348
[Abstract] [Full text] [PDF] [PubMed] [PMC]

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments
Zhekai Hu, Yuqing Li, Weihao Yuan, Lijian Jin, Wai Keung Leung, Chengfei Zhang, Yanqi Yang
Int. J. Biol. Sci. 2022; 18(15): 5753-5769. doi:10.7150/ijbs.74196
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Chronic Inflammation Pathway NF-κB Cooperates with Epigenetic Reprogramming to Drive the Malignant Progression of Glioblastoma
Kefeng Lin, Wenli Gao, Ning Chen, Shuyao Yang, Han Wang, Ran Wang, Fang Xie, Jiaqi Meng, Eric W.-F. Lam, Suyi Li, Wei Cheng, Puxiang Chen, Hongjin Wu, Jinsong Yan, Di Jin, Bilian Jin
Int. J. Biol. Sci. 2022; 18(15): 5770-5786. doi:10.7150/ijbs.73749
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Circular RNA hsa_circ_0003823 promotes the Tumor Progression, Metastasis and Apatinib Resistance of Esophageal Squamous Cell Carcinoma by miR-607/CRISP3 Axis
Yu-Ming Wang, Qi-Wu Zhao, Zhi-Yong Sun, Hai-Ping Lin, Xin Xu, Min Cao, Yu-Jie Fu, Xiao-Jing Zhao, Xiu-Mei Ma, Qing Ye
Int. J. Biol. Sci. 2022; 18(15): 5787-5808. doi:10.7150/ijbs.76096
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells
Xiao-jie Mi, Hye-Ryung Park, Sanjeevram Dhandapani, Sanghyun Lee, Yeon-Ju Kim
Int. J. Biol. Sci. 2022; 18(15): 5809-5826. doi:10.7150/ijbs.77734
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Humoral Immunogenicity to SARS-CoV-2 Vaccination in Liver Transplant Recipients: A Systematic Review and Meta-Analysis
Jeong-Ju Yoo, Dong Keon Yon, Seung Won Lee, Jae Il Shin, Beom Kyung Kim
Int. J. Biol. Sci. 2022; 18(15): 5849-5857. doi:10.7150/ijbs.77030
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3
Fei Li, Ting Xu, Peiling Chen, Rui Sun, Chaoyi Li, Xin Zhao, Jinxin Ou, Jingyao Li, Taoshu Liu, Maozhen Zeng, Weizhong Zheng, Yunchen Lin, Le Yang, Zecang Li, Haisheng Chen, Qing Zhang
Int. J. Biol. Sci. 2022; 18(15): 5858-5872. doi:10.7150/ijbs.76162
[Abstract] [Full text] [PDF] [PubMed] [PMC]

C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process
Nerea Palao, Celia Sequera, Ángel M Cuesta, Cristina Baquero, Paloma Bragado, Alvaro Gutierrez-Uzquiza, Aránzazu Sánchez, Carmen Guerrero, Almudena Porras
Int. J. Biol. Sci. 2022; 18(15): 5873-5884. doi:10.7150/ijbs.73192
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Anp32e promotes renal interstitial fibrosis by upregulating the expression of fibrosis-related proteins
Ju Wei, Yi Shan, Zheng Xiao, Lu Wen, Yilin Tao, Xi Fang, Hanwen Luo, Chengyuan Tang, Ying Li
Int. J. Biol. Sci. 2022; 18(15): 5897-5912. doi:10.7150/ijbs.74431
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Integrated pathological analysis to develop a Gal-9 based immune survival stratification to predict the outcome of lung large cell neuroendocrine carcinoma and its usefulness in immunotherapy
Yun Che, Zhiwen Luo, Yanan Cao, Jingnan Wang, Qi Xue, Nan Sun, Jie He
Int. J. Biol. Sci. 2022; 18(15): 5913-5927. doi:10.7150/ijbs.76936
[Abstract] [Full text] [PDF] [PubMed] [PMC]

FTO-mediated autophagy promotes progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability
Yawei Xu, Jingcheng Zhou, Lei Li, Wuping Yang, Zedan Zhang, Kenan Zhang, Kaifang Ma, Haibiao Xie, Zheng Zhang, Lin Cai, Yanqing Gong, Kan Gong
Int. J. Biol. Sci. 2022; 18(15): 5943-5962. doi:10.7150/ijbs.77774
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways
Zhangshuo Yang, Hao Zhang, Maohui Yin, Zhixiang Cheng, Ping Jiang, Maohui Feng, Bo Liao, Zhisu Liu
Int. J. Biol. Sci. 2022; 18(15): 5963-5977. doi:10.7150/ijbs.72982
[Abstract] [Full text] [PDF] [PubMed] [PMC]

SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment
Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang
Int. J. Biol. Sci. 2022; 18(15): 5978-5993. doi:10.7150/ijbs.74864
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

Engineering neoantigen vaccines to improve cancer personalized immunotherapy
Zaoqu Liu, Jinxiang Lv, Qin Dang, Long Liu, Siyuan Weng, Libo Wang, Zhaokai Zhou, Ying Kong, Huanyun Li, Yilin Han, Xinwei Han
Int. J. Biol. Sci. 2022; 18(15): 5607-5623. doi:10.7150/ijbs.76281
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies
Tingyu Fang, Hua Wang, Xiaoyue Pan, Peter J. Little, Suowen Xu, Jianping Weng
Int. J. Biol. Sci. 2022; 18(15): 5681-5697. doi:10.7150/ijbs.65044
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Functional and Structural Diversity of Insect Glutathione S-transferases in Xenobiotic Adaptation
Sonu Koirala B K, Timothy Moural, Fang Zhu
Int. J. Biol. Sci. 2022; 18(15): 5713-5723. doi:10.7150/ijbs.77141
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19
Man Wang, Wenguang Chang, Lei Zhang, Yuan Zhang
Int. J. Biol. Sci. 2022; 18(15): 5827-5848. doi:10.7150/ijbs.77561
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Recent advances in organotypic tissue slice cultures for anticancer drug development
Lin He, Chuxia Deng
Int. J. Biol. Sci. 2022; 18(15): 5885-5896. doi:10.7150/ijbs.78997
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers
Yue SUI, Jianping CHEN
Int. J. Biol. Sci. 2022; 18(15): 5928-5942. doi:10.7150/ijbs.76924
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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