Int J Biol Sci 2023; 19(5):1564-1578. doi:10.7150/ijbs.82352 This issue Cite
1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
2. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China
3. Department of Genetics, School of Life Science, Anhui Medical University, Hefei 230032, China
Aging is a necessary process of life associated with various mechanisms, such as genomic instability, loss of proteostasis, deregulated nutrient sensing, and cellular senescence, causing progressive dysregulation of the microenvironment, organ homeostasis and biological functions. The hepatic microenvironment is essential for maintaining liver homeostasis, in which hepatocytes, sinusoidal endothelial cells, stellate cells and immune cells are closely associated with the development of aging-related liver diseases. There is increasing evidence that immunocytes, especially myeloid cells, are involved in aging-related liver diseases such as alcoholic liver disease, nonalcoholic liver disease, liver fibrosis or cirrhosis and liver cancer, becoming promising treatment targets of these diseases. This review summarizes the phenotypic and functional alterations associated with aging liver and myeloid cells, as well as the roles of myeloid cells in the progression of aging-related liver diseases.
Keywords: Aging, Myeloid Cells, Microenvironment, Inflammation, Liver Disease