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Volume 20 (7); 2024
Research Papers
Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury Juan García-Sáez, María Figueroa-Fuentes, Carlos González-Corralejo, Cesáreo Roncero, Nerea Lazcanoiturburu, Álvaro Gutiérrez-Uzquiza, Javier Vaquero, Ester González-Sánchez, Kunzangla Bhutia, Silvia Calero-Pérez, Flavio Maina, Javier Traba, Ángela M. Valverde, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez
Int. J. Biol. Sci. 2024; 20(7): 2339-2355. doi:10.7150/ijbs.90645
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The dysadherin/FAK axis promotes individual cell migration in colon cancer Choong-Jae Lee, Tae-Young Jang, Jee-Heun Kim, Songwon Lim, Sunjae Lee, Jeong-Seok Nam
Int. J. Biol. Sci. 2024; 20(7): 2356-2369. doi:10.7150/ijbs.86699
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Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration Zhiqian Chen, Chen Chen, Xiao Yang, Yifan Zhou, Xiankun Cao, Chen Han, Tangjun Zhou, Jie Zhao, An Qin
Int. J. Biol. Sci. 2024; 20(7): 2370-2387. doi:10.7150/ijbs.88534
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Cancer-derived exosomal lncRNA SNHG3 promotes the metastasis of colorectal cancer through hnRNPC-mediating RNA stability of β-catenin Ling Huang, Guang Yang, Yanfei Shao, Jing Sun, Xiao Yang, Hiju Hong, Batuer Aikemu, Galiya Yesseyeva, Shuchun Li, Chengsheng Ding, Xiaodong Fan, Sen Zhang, Junjun Ma, Minhua Zheng
Int. J. Biol. Sci. 2024; 20(7): 2388-2402. doi:10.7150/ijbs.88313
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Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1 Yanling He, Xinyuan Zhang, Weijun Pan, Jiebiao Zhang, Weiliang Zhu, Jian Zhang, Jian Shi
Int. J. Biol. Sci. 2024; 20(7): 2403-2421. doi:10.7150/ijbs.87442
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Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells Yawen Hao, Shaohua Song, Tao Li, Qiuhong Zai, Ningning Ma, Yixin Li, Liu Yang, Peng Xiao, Tianyue Xu, Longshan Ji, Jiaxin Tan, Yeni Ait Ahmed, Xiaogang Xiang, Xiaolin Wang, Fouad Lafdil, Qing Xie, Yong He
Int. J. Biol. Sci. 2024; 20(7): 2422-2439. doi:10.7150/ijbs.92749
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TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway Chong Zhang, Fei-hua Du, Rou-xin Wang, Wen-bo Han, Xing Lv, Guo-qing Chen
Int. J. Biol. Sci. 2024; 20(7): 2440-2453. doi:10.7150/ijbs.85984
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Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang
Int. J. Biol. Sci. 2024; 20(7): 2454-2475. doi:10.7150/ijbs.91861
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Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons Yunhuan Gao, Yi Shi, Ming Wei, Xiaorong Yang, Yang Hao, Haifeng Liu, Yuan Zhang, Lu Zhou, Gang Hu, Rongcun Yang
Int. J. Biol. Sci. 2024; 20(7): 2476-2490. doi:10.7150/ijbs.91389
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The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation Yuanyuan Li, Baochen Ma, Zixu Wang, Yaoxing Chen, Yulan Dong
Int. J. Biol. Sci. 2024; 20(7): 2491-2506. doi:10.7150/ijbs.95316
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Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway Jing Lan, Ziteng Deng, Qiuzhen Wang, Dan Li, Kai Fan, Jianyu Chang, Yunfei Ma
Int. J. Biol. Sci. 2024; 20(7): 2507-2531. doi:10.7150/ijbs.94548
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Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice Bingsheng Yang, Wen Shu, Jin Hu, Zhongwen Wang, Jichang Wu, Jianwen Su, Jianye Tan, Bin Yu, Xianrong Zhang
Int. J. Biol. Sci. 2024; 20(7): 2555-2575. doi:10.7150/ijbs.93592
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Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma Dongxiao Tang, Luodan Zhao, Shuojin Huang, Wuguo Li, Qianting He, Anxun Wang
Int. J. Biol. Sci. 2024; 20(7): 2576-2591. doi:10.7150/ijbs.94795
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TAZ deficiency impairs the autophagy-lysosomal pathway through NRF2 dysregulation and lysosomal dysfunction Hyo Kyeong Kim, Hana Jeong, Mi Gyeong Jeong, Hee Yeon Won, Gibbeum Lee, Soo Han Bae, Miso Nam, Sung Hoon Lee, Geum-Sook Hwang, Eun Sook Hwang
Int. J. Biol. Sci. 2024; 20(7): 2592-2606. doi:10.7150/ijbs.88897
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Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis Yilan Li, Jingru Yan, Heng Sun, Yating Liang, Qianqian Zhao, Shan Yu, Yao Zhang
Int. J. Biol. Sci. 2024; 20(7): 2622-2639. doi:10.7150/ijbs.86479
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HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis Jin-Rong Guo, Kai-Yue He, Jia-Li Yuan, Wang An, Wei-Tao Yin, Qiu-Tong Li, Li-Yuan Lu, Jing-Yu Yang, Meng-Jie Liu, Yu-Jia Li, Yuan Zhao, Qi Yang, Xin-Yuan Lei, Fan Gao, Lei Zhang, Dan-Hui Wu, Jun-Qi Li, Zi-Long Zhao, Huai Liu, Ling-Jun Zhu, Xiong-Yan Xiang, Qian-Hui Sun, Yong-Ping Jian, Zhi-Xiang Xu
Int. J. Biol. Sci. 2024; 20(7): 2640-2657. doi:10.7150/ijbs.95595
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Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy Yuelin Xiao, Yiwang Zhang, Kaiduan Xie, Xiaoli Huang, Xianzhi Liu, Jinni Luo, Siwei Tan
Int. J. Biol. Sci. 2024; 20(7): 2658-2685. doi:10.7150/ijbs.90835
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E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS Min Zheng, Wenjing Liu, Rou Zhang, Dewei Jiang, Yujie Shi, Yingying Wu, Fei Ge, Ceshi Chen
Int. J. Biol. Sci. 2024; 20(7): 2686-2697. doi:10.7150/ijbs.92338
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Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway Wenbo Gao, Kaiyun Gu, Lunjie Ma, Fan Yang, Li Deng, Yaojia Zhang, Michael Z. Miao, Wenjun Li, Gang Li, Hong Qian, Zhen Zhang, Guixue Wang, Hongchi Yu, Xiaoheng Liu
Int. J. Biol. Sci. 2024; 20(7): 2727-2747. doi:10.7150/ijbs.90725
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Nuclear Softness Promotes the Metastatic Potential of Large-Nucleated Colorectal Cancer Cells via the ErbB4-Akt1-Lamin A/C Signaling Pathway Yangkun Li, Qilin Li, Lei Mu, Yibing Hu, Chang Yan, Hui Zhao, Yulong Mi, Xiaolan Li, Deding Tao, Jichao Qin
Int. J. Biol. Sci. 2024; 20(7): 2748-2762. doi:10.7150/ijbs.89481
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Multi-Omics profiling identifies aldehyde dehydrogenase 2 as a critical mediator in the crosstalk between Treg-mediated immunosuppression microenvironment and hepatocellular carcinoma Zhi-Yong Liu, Xia-Hui Lin, Hong-Ying Guo, Xuan Shi, Dan-Ying Zhang, Jia-Lei Sun, Guang-Cong Zhang, Ru-Chen Xu, Fu Wang, Xiang-Nan Yu, Dou Wang, Shu-Qiang Weng, Xi-Zhong Shen, Tao-Tao Liu, Ling Dong, Ji-Min Zhu
Int. J. Biol. Sci. 2024; 20(7): 2763-2778. doi:10.7150/ijbs.93075
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Reviews
Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine Miguel A Ortega, Oscar Fraile-Martinez, Diego de Leon-Oliva, Diego Liviu Boaru, Laura Lopez-Gonzalez, Cielo García-Montero, Miguel Angel Alvarez-Mon, Luis G Guijarro, Diego Torres-Carranza, Miguel A Saez, Raul Diaz-Pedrero, Agustin Albillos, Melchor Alvarez-Mon
Int. J. Biol. Sci. 2024; 20(7): 2532-2554. doi:10.7150/ijbs.95122
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Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy Xueting Ren, Shuai Lin, Feng Guan, Huafeng Kang
Int. J. Biol. Sci. 2024; 20(7): 2607-2621. doi:10.7150/ijbs.93806
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LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance Yuhan Huang, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Int. J. Biol. Sci. 2024; 20(7): 2698-2726. doi:10.7150/ijbs.91832
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Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy Rui Liang, Aoyu Cheng, Shengxin Lu, Xiaokun Zhang, Maomao Ren, Jiayi Lin, Ye Wu, Weidong Zhang, Xin Luan
Int. J. Biol. Sci. 2024; 20(7): 2779-2789. doi:10.7150/ijbs.95484
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