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Volume 21 (10); 2025

Research Papers

Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer Yuxin Xie, Huiling Li, Jian Pan, Yijian Li, Dongshan Zhang Int. J. Biol. Sci. 2025; 21(10): 4293-4311. doi:10.7150/ijbs.117443 Full text PDF PubMed PMC

Stabilization of OLFML1 via m⁶A Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC Yan Zhong, Jingfeng Liu, Wenwen Lin, Tian Peng, Lingfang Gao, Lan Shen, Ping Wang, Zhiyan Hu, Ting Long, Zuguo Li, Jingquan Liu Int. J. Biol. Sci. 2025; 21(10): 4334-4352. doi:10.7150/ijbs.111032 Full text PDF PubMed PMC

Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade Zhangzhen Du, Yongqi Zhao, Ke Zhang, Qiaozhen Qin, Changyi Luo, Jiamei Wu, Heyang Zhang, Shuirong Liu, Zhenhua Xu, Jing Zheng, Shuli Fan, Xiaoxia Jiang, Xu Li, Yan Wang Int. J. Biol. Sci. 2025; 21(10): 4353-4373. doi:10.7150/ijbs.105560 Full text PDF PubMed PMC

FABP7-mediated lipid-laden macrophages drive the formation of pre-metastatic niche and liver metastasis Shaowan Xu, Xin Peng, Zhenfang Wang, Chenchen Le, Xiangkun Wu, Zhicheng Zeng, Sisi Zeng, Ceng Zhang, Mingxing Qiu, Xin Zou, Hongxia Zhang, Feifei Wang, Wei Kang, Yanqing Ding, Li Liang Int. J. Biol. Sci. 2025; 21(10): 4388-4409. doi:10.7150/ijbs.110750 Full text PDF PubMed PMC

BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma Lei Li, Zixi Wang, Bohan Ma, Qi Ye, Yuzeshi Lei, Mingming Lu, Leihong Ye, Jialu Kang, Wenyue Huang, Shan Xu, Ke Wang, Yule Chen, Jing Liu, Yang Gao, Chenji Wang, Jian Ma, Lei Li Int. J. Biol. Sci. 2025; 21(10): 4410-4427. doi:10.7150/ijbs.115032 Full text PDF PubMed PMC

Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis Hao Chen, Yujia Cui, Jiazhou Li, Mengmeng Duan, Caixia Pi, Xuedong Zhou, Jing Xie Int. J. Biol. Sci. 2025; 21(10): 4428-4449. doi:10.7150/ijbs.110133 Full text PDF PubMed PMC

Nanog overexpression enhances the therapeutic efficacy of ADMSCs in AMI rats via the upregulation of JAK/STAT3 signaling and cyclin-mitochondrial expression Hsu-Ting Yen, David Kwan Ru Huang, Xian-Wu Lan, Jui-Ning Yeh, Yi-Ling Chen, Chi-Ruei Huang, Yi-Ting Wang, Hon-Kan Yip, Pei-Hsun Sung, Sheung-Fat Ko Int. J. Biol. Sci. 2025; 21(10): 4450-4466. doi:10.7150/ijbs.112824 Full text PDF PubMed PMC

Amlexanox Ameliorates Traumatic Brain Injury by Restoring Autophagy-Lysosomal Function via cAMP Signaling Modulation Seo Young Woo, Min Kyu Park, A Ra Kho, Hyun Wook Yang, Hyun Ho Jung, Jaewoo Shin, Minwoo Lee, Ha Na Kim, Jae Young Koh, Bo Young Choi, Sang Won Suh Int. J. Biol. Sci. 2025; 21(10): 4467-4484. doi:10.7150/ijbs.111216 Full text PDF PubMed PMC

The glucose sensor NSUN2-m⁵C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution Jing He, Boqiang Liu, Weijun Zhao, Hao Shen, Yi Wang, Weiqi Li, Chenqi Jin, Yifan Wang, Xiujun Cai, Liang Shi Int. J. Biol. Sci. 2025; 21(10): 4529-4548. doi:10.7150/ijbs.115610 Full text PDF PubMed PMC

LncRNA SLC7A11AR promotes lung adenocarcinoma progression by inhibiting ferroptosis via promoting SLC7A11 expression Haoqing Zhai, Xudong Xiang, Jun Pu, Xiaoqun Niu, Jie Gao, Dengcai Mu, Jia Du, Yao Li, Laihao Qu, Baiyang Liu, Yongbin Chen, Cuiping Yang Int. J. Biol. Sci. 2025; 21(10): 4549-4566. doi:10.7150/ijbs.112233 Full text PDF PubMed PMC

Ferritinophagy activation states determine the susceptibility to ferroptosis of macrophages in bone marrow and spleen Xin Lai, Aimin Wu, Yao Liu, Chen Liu, Junzhou Chen, Ke Gu, Bing Yu, Hui Yan, Junqiu Luo, Ping Zheng, Jie Yu, Daiwen Chen Int. J. Biol. Sci. 2025; 21(10): 4567-4585. doi:10.7150/ijbs.114545 Full text PDF PubMed PMC

Novel glycoprotein SBSPON suppressed bladder cancer through the AKT signal pathway by inhibiting HSPA5 membrane translocation Beibei Ni, Shi Li, Lan Zhao, Lin Gao, Liya Luo, Junwen Zhang, Xina Xie, Yuqi Zhu, Wei Yang, Shasha Min, Yan Wang, Xianxin Li, Zhiming Cai, John R. Speakman, Zesong Li Int. J. Biol. Sci. 2025; 21(10): 4586-4603. doi:10.7150/ijbs.109973 Full text PDF PubMed PMC

Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2-GADD45A-Mediated DNA Damage Repair Hongzhong Zhou, Liwen Zhu, Yajun Zhang, Lichan Chen, Dong-Mei Gou, Haohua Zhang, Rongmao Hua, Jianning Song, Chuanghua Qiu, Fu-Wen Yao, Xiafei Wei, Dayong Gu, Yong Xu Int. J. Biol. Sci. 2025; 21(10): 4629-4646. doi:10.7150/ijbs.111142 Full text PDF PubMed PMC

SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis Qiwen Yu, Dongjing Yang, Binli Ran, Jie Pan, Yaodong Song, Mengwei Cui, Qianqian He, Chaopeng Mei, Haifeng Wang, Huihui Li, Guanghui Li, Yinuo Meng, Fazhan Wang, Wenzhi Guo, Changju Zhu, Sanyang Chen Int. J. Biol. Sci. 2025; 21(10): 4663-4682. doi:10.7150/ijbs.114510 Full text PDF PubMed PMC

Novel High-Throughput Screen Identified S100A4 Inhibitors for Anti-Metastatic Therapy Paul Curtis Schöpe, Nina Heisterkamp, Devin Schütz, Guido Mastrobuoni, Kerstin Putzker, Ulrike Uhrig, Wolfgang Walther, Stefan Kempa, Marc Nazaré, Dennis Kobelt, Ulrike Stein Int. J. Biol. Sci. 2025; 21(10): 4683-4700. doi:10.7150/ijbs.113805 Full text PDF PubMed PMC

Reviews

Beyond polarization: macrophage senescence in immunoregulation and cancer therapy Mei Song, Lifen Zhang, Xiaofeng Dai, Shiliang Ji, Jiayin Shen, Weiling He Int. J. Biol. Sci. 2025; 21(10): 4312-4333. doi:10.7150/ijbs.115921 Full text PDF PubMed PMC

Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease Hua Miao, Shui-Juan Zhang, Xin Wu, Ping Li, Ying-Yong Zhao Int. J. Biol. Sci. 2025; 21(10): 4374-4387. doi:10.7150/ijbs.115359 Full text PDF PubMed PMC

Cancer patient-derived organoids: Novel models for the study of natural products Shuxin Liu, Ren Zhang, Yachen Liu, Xian Lin, Jian Chen Int. J. Biol. Sci. 2025; 21(10): 4485-4503. doi:10.7150/ijbs.114373 Full text PDF PubMed PMC

New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets Kenly Wuputra, Chia-Che Ku, Wen-Hung Hsu, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chih-Yen Chen, Yoshiharu Tanaka, Ying-Chu Lin, Chao-Hung Kuo, Deng-Chyang Wu, Kazunari K. Yokoyama Int. J. Biol. Sci. 2025; 21(10): 4504-4528. doi:10.7150/ijbs.112869 Full text PDF PubMed PMC

Harnessing Natural Products to Surmount Drug Resistance in Gastric Cancer: Mechanisms and Therapeutic Perspectives QingShui Wang, Fangqin Xue, Yehuda G. Assaraf, Yao Lin Int. J. Biol. Sci. 2025; 21(10): 4604-4628. doi:10.7150/ijbs.113709 Full text PDF PubMed PMC

Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease Hui Zhao, Jia Guo Int. J. Biol. Sci. 2025; 21(10): 4647-4662. doi:10.7150/ijbs.112737 Full text PDF PubMed PMC

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