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Volume 21 (11); 2025
Research Papers
TSG6 promotes epithelial-mesenchymal transition and tumor-associated macrophage polarization through Smad2/3 and MAPK signaling by facilitating TSG6-CD44-TGFβR1 or EGFR complex formation Hyun-Ji Oh, Ga-Hong Min, Da-Eun Kim, Sol-bi Shin, Hyungshin Yim
Int. J. Biol. Sci. 2025; 21(11): 4701-4718. doi:10.7150/ijbs.115097
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Sesamin Induces MCL-1-Dependent Apoptosis in Activated T Cells and Ameliorates Experimental Atopic Dermatitis Hee-Suk Park, Woo Jung Sung, Yoon-Yub Park, Jaewoo Hong, Hoon-Kyu Oh, Hyun-Su Lee
Int. J. Biol. Sci. 2025; 21(11): 4719-4735. doi:10.7150/ijbs.116753
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METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression Jie Li, Qian Luo, Minjie Lu, Chen Lu, Caihong Xu, Jie Ding, Tian Zhan, Jing Zhu, Mengsen Qian, Shuhui Lin, Lisha Chang, Juan Li, Keming Wang
Int. J. Biol. Sci. 2025; 21(11): 4782-4797. doi:10.7150/ijbs.105391
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Histone Methyltransferase SETD1B Maintains Cancer Stem Cell Niche by Regulating the Crosstalk between CD24 and Surface Adhesion Molecules in Hepatocellular Carcinoma Yan Gao, Wei Zhou, Yuehong Gao, Shunxi Wang, Zhiling Xu, Xiao Xiang, Li Yang
Int. J. Biol. Sci. 2025; 21(11): 4798-4815. doi:10.7150/ijbs.112943
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JCAD-Derived from Plasma Exosomes: Promoting Tumor Cell Progression and Predicting Poor Outcomes in Breast Cancer Douwaner Liu, Min Xiong, Xiaoting Chen, Xuliren Wang, Yuting Sang, Shiyang Liu, Liyi Zhang, Weiru Chi, Hengyu Ren, Bingqiu Xiu, Qi Zhang, Yayun Chi, Jiong Wu, Jingyan Xue
Int. J. Biol. Sci. 2025; 21(11): 4816-4833. doi:10.7150/ijbs.107763
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Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription Qing Lu, Xiuhe Lv, Jin Wang, Bihan Xia, Hailin Yan, Zhu Wang, Jinlin Yang
Int. J. Biol. Sci. 2025; 21(11): 4834-4850. doi:10.7150/ijbs.105629
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CREB Regulates Cisplatin Resistance by Targeting TNKS and KDM6A in NSCLC cell-Derived Tumor Spheroid Ji Hae Lee, Youngjoo Kwon, Kyungsil Yoon
Int. J. Biol. Sci. 2025; 21(11): 4851-4871. doi:10.7150/ijbs.109419
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Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications Yuxing Chen, Yong Tao, Qiu Huang, Jingtao Xu, Zhenxin Wang, Ye Zhang, Guangxu Fu, Fuqiang Tan, Keyi Feng, Yunsheng Ou
Int. J. Biol. Sci. 2025; 21(11): 4872-4894. doi:10.7150/ijbs.113785
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A Small Molecule Selectively Targets N-Myc to Suppress Neuroblastoma Cancer Progression Ying Miao, Huang Chen, Yuzhan Li, Liting Li, Jiangnan Ye, Jingwen Zhang, Jiayu Wang, Haigang Wu, Guihong Li, Yihua Chen, Zhengfang Yi, Mingyao Liu
Int. J. Biol. Sci. 2025; 21(11): 4895-4907. doi:10.7150/ijbs.97195
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N4-acetylcytidine modification of LINC02802 promotes non-small cell lung cancer progression by modulating mitochondrial NAD+/NADH ratio Yixiao Yuan, Dahang Zhang, Juan Wang, Lin Tang, Yaowu Duan, Lincan Duan, Xiulin Jiang
Int. J. Biol. Sci. 2025; 21(11): 4908-4926. doi:10.7150/ijbs.116639
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MALAT1 promotes malignancy of HBV-related hepatocellular carcinoma by regulating IGF2BP3-mediated nuclear-cytoplasmic shuttling Ze-Bang Du, Xin-Mou Wu, Tun Han, Yu-Xin Cai, Bo Qian, Yu-Shi Shen, Han-Yu Zhang, Jia-Shen Wu, Jie He, Xiao-Xuan Chen, Dong-Bei Guo, Hang-Tian Zhong, Xiong Li, Lei Zhang, Xiao-Ming Luo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Int. J. Biol. Sci. 2025; 21(11): 4942-4960. doi:10.7150/ijbs.112133
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Blocking interplay between TERT and c-Myc: a new therapeutic strategy for BRAFV600E/pTERT double mutated tumors Jing Wei, Jiazhe Liu, Yan Zhang, Guobin Wang, Xiao Cui, Wei Yu, Chunlei Nie, Peng Hou
Int. J. Biol. Sci. 2025; 21(11): 4961-4978. doi:10.7150/ijbs.111224
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PLK4 as a Key Regulator of Neuroblastoma Differentiation and a Promising Therapeutic Target Xiangdong Tian, Yuren Xia, Wenchen Gong, Kangwei Zhu, Yulong Yang, Zhiqiang Han, Yun Liu, Jie Li, Xin Li, Yuchao He, Mingyou Gao, Lu Chen, Hua Guo, Qiang Zhao
Int. J. Biol. Sci. 2025; 21(11): 4979-4996. doi:10.7150/ijbs.111449
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Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer Xuetao Lei, Boyang Zheng, Yanmei Peng, Guofan Zhang, Xia Cheng, Wenqiang Li, Jiayong He, Fengping Li, Ruoyu Ling, Ziyi Fu, Qingbin Yang, Gengtai Ye, Guoxin Li
Int. J. Biol. Sci. 2025; 21(11): 4997-5014. doi:10.7150/ijbs.113325
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Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion Zhijun Pan, Xinyuan Jin, Qing Li, Yuqing Zhou, Yupeng Zeng, Xin Wang, Yufeng Jin, Yu Chen, Dan Li, Wenhua Ling
Int. J. Biol. Sci. 2025; 21(11): 5015-5033. doi:10.7150/ijbs.116929
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Activation of sphingosine-1-phosphate receptors can relieve myocardial ischemia-reperfusion injury by mitigating oxidative stress and ferroptosis in cardiomyocytes Xuan Xu, Runqian Li, Shengnan Li, Qin Wei, Fuchao Yu, Genshan Ma, Jiayi Tong
Int. J. Biol. Sci. 2025; 21(11): 5079-5096. doi:10.7150/ijbs.107402
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Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication Xiangguang Shi, Xueyi Xia, Yang Xiao, Huizhen Shu, Zhuoya Xu, Mengguo Liu, Chenyi Shi, Ying Zhang, Yining Wei, Yiyi Gong, Wei Wang, Yahui Chen, Jianlan Liu, Jia Huang, Mengkun Shi, Jiucun Wang, Wenyu Wu
Int. J. Biol. Sci. 2025; 21(11): 5097-5115. doi:10.7150/ijbs.114930
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Reviews
The function of GPCRs in different bone cells Yan Zhang, Nai-Ning Wang, Zi-Han Qiu, Jia-Hao Wang, Wen-Na An, Li-Dan Shi, Fei Chen, Da-Jin Zhang, Si-Yue Wang, Tie-Lin Yang, Shou-Ye Hu, Yan Guo
Int. J. Biol. Sci. 2025; 21(11): 4736-4761. doi:10.7150/ijbs.113585
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Mesangial Cells in Diabetic Kidney Disease: From Mechanisms to Therapeutic Implications Li Feng, Yu-ying Feng, Qian Ren, Ping Fu, Liang Ma
Int. J. Biol. Sci. 2025; 21(11): 4762-4781. doi:10.7150/ijbs.114907
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Epigenetic orchestration of RNA m6A methylation in wound healing and post-wound events Heao Zhang, Delong Gao, Zixin Li, Sis Aghayants, Yiping Wu, Zeming Liu, Qi Zhang
Int. J. Biol. Sci. 2025; 21(11): 4927-4941. doi:10.7150/ijbs.114988
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Lactate metabolic reprogramming and histone lactylation modification in sepsis Ji Zhang, Dan Wu, Fu Zeng, Haiyun Gu, Chengbao Li, Juan P Cata, Kefang Guo, Changhong Miao, Hao Zhang
Int. J. Biol. Sci. 2025; 21(11): 5034-5055. doi:10.7150/ijbs.116088
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Innate Immunity Reimagined: Metabolic Reprogramming as a Gateway to Novel Therapeutics Chuan-Han Deng, Chen-Tong Wang, Xin Zhou, Xin Chen, Ying Wang
Int. J. Biol. Sci. 2025; 21(11): 5056-5078. doi:10.7150/ijbs.114010
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siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention Rahul Bhattacharjee, Debanjan Das, Srija Chakraborty, Radheka Bhaduri, Soham Chattopadhyay, Rajeev K Singla, Vinoth Kumarasamy, Rohit Gundamaraju
Int. J. Biol. Sci. 2025; 21(11): 5116-5134. doi:10.7150/ijbs.109637
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Roles of SIRT3 in aging and aging-related diseases Yuzi You, Zhong Wang
Int. J. Biol. Sci. 2025; 21(11): 5135-5163. doi:10.7150/ijbs.115518
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