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Volume 21 (13); 2025
Research Papers
GPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas Carmen Huergo, Juan Tornín, Oscar Estupiñán, Paula Díez, Borja Gallego, Jun Gao, Marybeth Creskey, Gauri Muradia, M Victoria González, Dzohara Murillo, Verónica Rey, Lucia Martínez-Cruzado, Sofía T. Menéndez, Mar Rodríguez‑Santamaría, Verónica Blanco, Isabel Quirós, Rosa M. Sáinz, Michael Rosu-Myles, Jessie R. Lavoie, René Rodríguez
Int. J. Biol. Sci. 2025; 21(13): 5609-5627. doi:10.7150/ijbs.105217
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NDR1 enhances USP9X-mediated AR deubiquitination and promotes enzalutamide resistance in castration-resistant prostate cancer Zeyuan Zheng, Jinxin Li, Yifan Du, Liyan Li, Qingqing Wu, Bin Liu, Haodong Wu, Zeyi Zhang, Zuodong Xuan, Yue Zhao, Huimin Sun, Chen Shao
Int. J. Biol. Sci. 2025; 21(13): 5628-5644. doi:10.7150/ijbs.114686
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TRAF2 Promotes Liver Fibrosis via Regulation of the HIF-1α/GLUT1-Mediated Glycolysis in Hepatic Stellate Cells Yina Zhang, Siduo Xu, Jiajia Shao, Yining Lu, Lingzhu Zhao, Xue Liang, Jiping Yao, Minwei Li, Yanning Liu, Min Zheng
Int. J. Biol. Sci. 2025; 21(13): 5645-5665. doi:10.7150/ijbs.99682
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Mettl1-mediated m7G modification of Fgfr2 regulates osteogenic and chondrogenic differentiation of mesenchymal stem cells Quanfeng Li, Yunhui Zhang, Pengfei Ji, Yibin Zhang, Jianan Jiang, Jiahao Jin, Zihao Yuan, Guangqi Tian, Mingxi Cai, Pei Feng, Yanfeng Wu, Wenjie Liu, Peng Wang
Int. J. Biol. Sci. 2025; 21(13): 5704-5724. doi:10.7150/ijbs.114889
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dsHMGB1, released from IL-17A-induced pyroptotic prostate epithelial cells, drives M1 polarization by promoting Pfkp-mediated glycolysis via Jak2/Stat1 transcription in experimental autoimmune prostatitis Wenming Ma, Yi Zhang, Wenlong Xu, Yongtao Hu, Weikang Wu, Lei Chen, Li Zhang, Hexi Du, Jialin Meng, Jing Chen, Chaozhao Liang
Int. J. Biol. Sci. 2025; 21(13): 5725-5743. doi:10.7150/ijbs.113908
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Sec10 negatively regulates antiviral immunity by downregulating NRF2-ATF4-RIG-I axis Peili Hou, Fuzhen Zhang, Xiaonan Sun, Hongchao Zhu, Yueyue Feng, Jun Wang, Xiaoyun Wang, Yuanyuan Han, Rui Li, Chuanhong Wang, Yingying Li, Hongmei Wang, Hongbin He
Int. J. Biol. Sci. 2025; 21(13): 5744-5761. doi:10.7150/ijbs.117430
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Neutrophil Recruitment via Hepatocyte IL-1α Drives NETs-Mediated AIM2 Hepatocyte Apoptosis in Alcohol-associated steatohepatitis Yuan Zhang, Xueteng Meng, Yan Ding, Jinmao Yu, Yunyun Wan, Zhiying Yang, Zheyu Han, Qian Zhu, Rui Feng, Jun Li, Cheng Huang, Taotao Ma
Int. J. Biol. Sci. 2025; 21(13): 5762-5781. doi:10.7150/ijbs.121255
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NR5A2 (located on chromosome 1q32) inhibits ferroptosis and promotes drug resistance by regulating phospholipid remodeling in multiple myeloma Panpan Li, Jiadai Xu, Bei Xu, Xiaowen Hu, Yaqin Xiong, Yawen Wang, Peng Liu
Int. J. Biol. Sci. 2025; 21(13): 5789-5801. doi:10.7150/ijbs.113115
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The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury Lishan Liu, Fangxu Chen, Kang Liu, Feng Xu, Ruihua Shen, Juanjuan Jiang, Fang Lu, Jingfeng Zhu, Simeng Liu, Lin Wu, Ao Bian, Jamie R Privratsky, Steven D. Crowley, Lianmin Chen, Changying Xing, Yanggang Yuan, Zhimin Huang, Huijuan Mao, Jiafa Ren
Int. J. Biol. Sci. 2025; 21(13): 5802-5820. doi:10.7150/ijbs.110790
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Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis Yujiao Liu, Lizhou Zhao, Molin Li, Weimin Gong, Xiaofang Wang, Yu Cheng, Ying Zhang, Pengtao Wang, Yisheng Luo, Yining Zhang, Yufei Shao, Makoto Mark Taketo, Teresita Bellido, Gaohai Shao, Xing Liu, Xiaolin Tu
Int. J. Biol. Sci. 2025; 21(13): 5821-5841. doi:10.7150/ijbs.117481
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TGF-βI/FERMT2/COL6A1 Reciprocal Loop Drives Tumor-Stroma Crosstalk and Promotes Peritoneal Metastasis in Gastric Cancer Chao He, Zheng Zhou, Jiayue Ye, Xiangliu Chen, Yan Yang, Xinguang Jin, Quan Zhou, Lisong Teng
Int. J. Biol. Sci. 2025; 21(13): 5859-5873. doi:10.7150/ijbs.119895
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TPL2 Promotes Gastric Cancer Progression and Chemoresistance Through a Hypoxia-Induced Positive Feedback Loop with PPARδ Keng-Li Lan, De-Wei Lai, Cheng-Ning Yang, Hung-Chuan Pan, Hui-Ting Ou, Szu-I Yu, Tsung-Che Hsieh, Yi-Lun Ye, Chia-Yang Chan, Kin-Long Chou, Sheng-Mao Wu, Li-Wei Shen, Chin-Chang Shen, Lujen Chen, Shing-Hwa Liu, Chien‑Shan Chiu, Jack L Arbiser, Meei-Ling Sheu
Int. J. Biol. Sci. 2025; 21(13): 5874-5890. doi:10.7150/ijbs.111998
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Cyclin D1/CDK coordination with the cellular prion protein upregulated cell proliferation signaling and preserved neurological function in acute IS rats Kun-Chen Lin, Kuan-Hung Chen, John Y. Chiang, Han-Tan Chai, Chi-Ruei Huang, Yi-Ling Chen, Yi-Ting Wang, Jun Guo, Hon-Kan Yip
Int. J. Biol. Sci. 2025; 21(13): 5905-5921. doi:10.7150/ijbs.98013
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Smad3 Mediates Renal Fibrosis via GPX4-Dependent Ferroptosis Kaixiang Liu, Min Yu, Yangyang He, Yi Li, Xiao-ru Huang, Guisen Li, Li Wang, Hui-yao Lan, Xiang Zhong
Int. J. Biol. Sci. 2025; 21(13): 5922-5935. doi:10.7150/ijbs.114075
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HIF-1-mediated macrophage metabolic reprogramming promotes AKI to CKD transition Hong Ding, Yan Zhou, Ren-He Zhu, Shu Yu, Ai-Qing Zhang, Hong Liu, Jia-Ling Ji, Zuo-Lin Li
Int. J. Biol. Sci. 2025; 21(13): 5936-5955. doi:10.7150/ijbs.111238
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PRMT1/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy Yu Han, Lie Ma, Xiaolei Zhang, Qingyuan Ren, Qingxia Yuan, Jiawen Zhou, Yanjing Ren, Na Wan, Xin Jin, Jingyao Hou, Yanbo Wang, Baiqu Huang, Yu Zhang, Jun Lu
Int. J. Biol. Sci. 2025; 21(13): 5956-5974. doi:10.7150/ijbs.115225
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Bringing p53 Back: A Prion-Powered Attack on Retinoblastoma Yuyan Ma, Siqi Yan, Weiming You, Peili Wang, Wangxiao He, Yu Yao, Xiaoqiang Zheng
Int. J. Biol. Sci. 2025; 21(13): 5975-5988. doi:10.7150/ijbs.113116
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Reviews
Immunotherapy resistance in MASLD-related hepatocellular carcinoma: special immune microenvironment and gut microbiota Jie Jin, Kun Cheng, Mingrui Chen, Huifang Liang, Wanguang Zhang
Int. J. Biol. Sci. 2025; 21(13): 5666-5690. doi:10.7150/ijbs.117394
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Pathophysiology, development, and mortality of major non-communicable diseases in metabolic dysfunction-associated steatotic liver disease: A comprehensive review Minjeong Kang, Jihun Song, Eun Seok Kang, Seohui Jang, Taeho Kwak, Yihyun Kim, Meng Sha, Hwamin Lee, Seogsong Jeong
Int. J. Biol. Sci. 2025; 21(13): 5691-5703. doi:10.7150/ijbs.117211
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Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets Hao Wang, Jun Guo, Eric Chung
Int. J. Biol. Sci. 2025; 21(13): 5842-5858. doi:10.7150/ijbs.120980
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Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis Jianzhang Wang, Xinqi Mao, Libo Zhu, Xinmei Zhang
Int. J. Biol. Sci. 2025; 21(13): 5891-5904. doi:10.7150/ijbs.116635
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Commentaries
Stem cells enhance their chondrogenic differentiation in hydrogels by mechanical tumbling Xuemiao Liu, Weiguo Zhang, Xing Wang
Int. J. Biol. Sci. 2025; 21(13): 5782-5784. doi:10.7150/ijbs.118859
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Remodeling the Tumor Immune Environment in Breast Cancer via Bortezomib-based Combination Therapy Shaojuan Huang, Qiang Chen
Int. J. Biol. Sci. 2025; 21(13): 5785-5788. doi:10.7150/ijbs.122366
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