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Volume 21 (14); 2025
Research Papers
Macrophage Extracellular Traps Modulate the Compensatory Anti-inflammatory Response Syndrome through IL-33/ST2 Signaling in Severe Acute Pancreatitis Quan Zhou, Zhao Shi, Xuan Wang, Lingxi Meng, Kun Liu, Siqi Zhou, Yihang Jiang, Shuang Nie, Yuanyuan Yu, Hao Zhu, Mingdong Liu, Bo Kong, Helmut Friess, Lei Wang, Hongzhen Li, Shanshan Shen, Xiaoping Zou
Int. J. Biol. Sci. 2025; 21(14): 5989-6006. doi:10.7150/ijbs.116740
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Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity Shih-Chao Hsu, Yu-Hao He, Yun-Ju Chen, Uyen Nguyen Phuong Le, Pei-Tong Liu, Thanh Kieu Huynh, Yi-Ling Chen, Ya-Ling Wei, Hsin-Chiao Chou, Wei-Chien Huang, Long-Bin Jeng
Int. J. Biol. Sci. 2025; 21(14): 6007-6024. doi:10.7150/ijbs.116148
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The Remodeling of Mitochondrial-Endoplasmic Reticulum Contacts by Omega-3 Fatty Acids Mitigates Dietary Advanced Glycation End Product-Driven Sertoli Cell Senescence and Oligoasthenozoospermia Zhaowanyue He, Feiyan Ge, Chuwei Li, Min Zang, Chun Cao, Jing Zhang, Shanshan Sun, Hong Zhang, Yijian Xiang, Yao Xu, Kuan Liang, Yuming Feng, Zhichuan Zou, Hui Wang, Weiqing Chen, Jie Dong, Jinzhao Ma, Shanmeizi Zhao, Li Chen, Jun Jing, Rujun Ma, Xie Ge, Bing Yao
Int. J. Biol. Sci. 2025; 21(14): 6042-6061. doi:10.7150/ijbs.117091
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METTL3-mediated m6A methylation on lncRNA H19 inhibits intrahepatic cholangiocarcinoma progression through PPARγ downregulation Rong Xiao, Xinya Lu, Fang Huang, Yaru Zhao, Hao Jin, Xiaoyuan Jia, Biao Huang, Yigang Wang, Liang Chu
Int. J. Biol. Sci. 2025; 21(14): 6062-6080. doi:10.7150/ijbs.120413
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Cardiomyocyte GSDME Drives Doxorubicin-Induced Cardiotoxicity by Targeting the CCL2-CCR2 Axis Junqiang Xue, Shiyao Xie, Xuelin Cheng, Enyong Su, Xiaoyue Song, Lili Wei, Peng Yu, Ming Liu, Hong Jiang
Int. J. Biol. Sci. 2025; 21(14): 6113-6131. doi:10.7150/ijbs.115489
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Repetitive Trans-spinal Magnetic Stimulation Suppresses Microglia to Engulf Synapse and Promotes Nerve Repairment via cGAS-STING Signaling Pathway after Spinal Cord Injury Mudan Huang, Jiawei Di, Na Li, Longyou Xiao, Zhenming Tian, Tianwei He, Mao Pang, Bin Liu, Lei He, Limin Rong
Int. J. Biol. Sci. 2025; 21(14): 6132-6155. doi:10.7150/ijbs.114428
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Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury Xi Wu, Ting Wu, Xiufen Wang, Meiyu Zeng, Chengyuan Tang, Juan Cai, Anqun Chen, Guochun Chen, Zhiwen Liu, Yu Liu, Shaobin Duan
Int. J. Biol. Sci. 2025; 21(14): 6156-6178. doi:10.7150/ijbs.117838
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Gli1 regulates fibro/adipogenic progenitor function through modulation of Ido1 in muscle regeneration Lili Han, Fengmin Zhang, Jujin Zhang, Xiaonan Li, Kunpeng Wang, Biao Liu, Jiawen Song, Xinyan Liu, Yun Qian, Kai Li, Yingnan Lei, Claudia Spits, Yi Chang, Chengle Zhuang, Zhen Yu, Yun Zhao, Jiayin Peng
Int. J. Biol. Sci. 2025; 21(14): 6197-6214. doi:10.7150/ijbs.116134
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STK32C as a Therapeutic Target in Colorectal Cancer via HSP90-PI3K/AKT/mTOR Signaling Chi-Hoon Ahn, Ji Eon Park, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim
Int. J. Biol. Sci. 2025; 21(14): 6215-6233. doi:10.7150/ijbs.121647
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Generation of Human 3D Airway Assembloids for Advanced Modeling Maria Chiara Iachini, Alberto Coglot, Dorian Tace, Noemi Elia, Francesco Rusconi, Federica Cosentino, Gianluca Lopez, Mariacristina Crosti, Tuğba Dursun Usal, Edoardo Scarpa, Antonio D'Amore, Vitale Miceli, Lorenzo Rosso, Lorenza Lazzari
Int. J. Biol. Sci. 2025; 21(14): 6234-6251. doi:10.7150/ijbs.113920
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Synergistic Effects of Radiotherapy and PD‑1 Blockade in a Human‑Mimetic BRCAness Model of Triple-Negative Breast Cancer Eun Ju Cho, Min Kyung Ki, Hye Jung Baek, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Chu-Xia Deng, Beom K. Choi, Sang Soo Kim
Int. J. Biol. Sci. 2025; 21(14): 6270-6284. doi:10.7150/ijbs.118427
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Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling Lian Li, Yuchen Liu, Lifan Liu, Shanshan Zhao, Jianqi Feng, Jiayi Zhou, Yanqun Zhang, Xiaohang Shen, Xinlong Wang, Kechen Chen, Jie Lv, Kaican Cai, Shuan Rao, Zhili Rong, Ying Lin
Int. J. Biol. Sci. 2025; 21(14): 6285-6304. doi:10.7150/ijbs.118304
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DPP7 promotes fatty acid β-oxidation in tumor-associated macrophages and determines immunosuppressive microenvironment in colorectal cancer Jiang Chang, Yuxu Niu, Shizhao Zhou, Weiying Zhu, Ziqi Zhang, Haoran Xiu, Ke Shang, Qingyang Feng, Ye Wei
Int. J. Biol. Sci. 2025; 21(14): 6305-6325. doi:10.7150/ijbs.117909
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TTC36-Mediated Tumor Suppression via YBX3/SPRED1 Axis Paradoxically Reduces Sorafenib Sensitivity in Hepatocellular Carcinoma Wenhu Zhao, Xiangyu Ling, Kuan Li, Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Chao Xu, Qingpeng Lv, Deming Zhu, Zhiwen Feng, Xiaoming Ai, Lianbao Kong, Wenzhou Ding
Int. J. Biol. Sci. 2025; 21(14): 6351-6372. doi:10.7150/ijbs.115727
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Tumor-Derived Lactate Drives Malignant Progression of Refractory Papillary Thyroid Carcinoma via the H3K18la-STAT1-LDHA Axis Zheng Zhou, Chao He, Xumeng Wang, Xinguang Jin, Liping Wen, Yan Yang, Quan Zhou, Weibin Wang, Lisong Teng
Int. J. Biol. Sci. 2025; 21(14): 6373-6388. doi:10.7150/ijbs.120277
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Spatial Cell Atlas of Lateral Septum Reveals Changes Underlying Anxiety and Fear Learning Deficits in Mice with Abnormal Immunity Yian Wang, Wenxia Gao, Xueyan Yang, Zirui Liu, Hisham Al-Ward, Orion R Fan, Yiming Shao, Liqiang Zhou, Bo Jing, Qianxiang Wu, Wenmin Zhu, Wei Chen, Yi Eve Sun
Int. J. Biol. Sci. 2025; 21(14): 6389-6410. doi:10.7150/ijbs.117249
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Glycolysis drives STING signaling to promote M1-macrophage polarization and aggravate liver fibrosis Ping Chen, Zijing Zhu, Wenjie Chen, Zhiyu Xiong, Kan Shu, Muhua Sun, Yingan Jiang, Lanjuan Li
Int. J. Biol. Sci. 2025; 21(14): 6411-6429. doi:10.7150/ijbs.115073
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Cardiac fibroblast-derived IGFBP6 orchestrates cardiac remodeling by coupling the EGR1-MFAP4 axis Shaopeng Cheng, Yilin Wang, Kunsheng Li, Xiaoting Wu, Qianwen Zhao, Tingting Tong, Jian Shi, Yunxing Xue, Jie Yang, Dongjin Wang
Int. J. Biol. Sci. 2025; 21(14): 6430-6451. doi:10.7150/ijbs.114417
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An efficient neural network of cooperating serotonergic and noradrenergic neurons in modulating sudden unexpected death in epilepsy Qing Xu, XiaoXia Xu, LeYuan Gu, YaXuan Wu, Yue Yang, ZhuoYue Zhang, ZiWen Zhang, XuanYi Di, XiTing Lian, Qian Yu, YuLing Wang, HaiXiang Ma, WeiHui Shao, Lu Liu, JiaXuan Gu, Fei Tong, HongHai Zhang
Int. J. Biol. Sci. 2025; 21(14): 6452-6481. doi:10.7150/ijbs.114659
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Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway Haohua Huang, Hua Liao, Yixin Chen, Minxuan Hu, Xiaoxiao Jiang, Qi Yu, Yimei Gao, Huimin Yang, Jinzhong Zhuo, Dongyu Liu, Liping Huang, Jinming Zhang, Yanqun Li, Yuhan Du, Xiaodong Lin, Xiaojing Meng, Fei Zou, Mengchen Zou, Jieyu Wu, Shaoxi Cai, Hangming Dong
Int. J. Biol. Sci. 2025; 21(14): 6482-6500. doi:10.7150/ijbs.119486
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Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes Ziyu Zhang, Nannan Du, Gege He, Mengting Zhang, Gaifeng Zhang, Jie Gao, Ying Liu, Yuezhen Deng, Lunquan Sun, Min Li
Int. J. Biol. Sci. 2025; 21(14): 6501-6521. doi:10.7150/ijbs.114791
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Lactobacillus paracasei ZJUZ2-3 inhibits gastrointestinal tumors via the IAA-induced AHR/MTDH/NF-κB axis Rui Yang, Yan Yang, Wu Lin, Kaikai He, Dexi Bi, Lisong Teng
Int. J. Biol. Sci. 2025; 21(14): 6522-6541. doi:10.7150/ijbs.114602
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Reviews
The PI3K/Akt/mTOR Pathway: Immuno-Metabolic Orchestration in IR/MASH-Associated Hepatocellular Carcinoma Jian Zhao, Yuehua Zhang, Zhigong Wei, Kai Li, Lei Sun, Dan Li, Yongsheng Wang
Int. J. Biol. Sci. 2025; 21(14): 6025-6041. doi:10.7150/ijbs.120657
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Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance Shuai Xiao, Lingli Tian, Xiaoli Gan, Xiaozhen Xu, Meng Liao, Dandan Song, Yeping Yu, Wenying Qin, Rui Zhang, Hao Lyu, Dong Guo, Qi Zhang, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Int. J. Biol. Sci. 2025; 21(14): 6081-6112. doi:10.7150/ijbs.115401
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Circular RNA-Encoded Proteins in Disease Pathogenesis Jude Uzoechina, Zhijun Zhang
Int. J. Biol. Sci. 2025; 21(14): 6179-6196. doi:10.7150/ijbs.110146
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Unveiling the dynamics and therapeutic potential of m6A methyltransferases and demethylases in liver diseases Ya-Ning Chen, Sai Zhu, Li-Jiao Sun, Rong-Rong Zhou, Rui Zheng, Xiao-Feng Li, Liang-Yun Li, Si-Jin Sun, Yu-Xin Zhao, Cheng Huang, Xiao-Ming Meng, Lei Zhang, Xiong-Wen Lv, Hua Wang, Xin Chen, Jun Li
Int. J. Biol. Sci. 2025; 21(14): 6252-6269. doi:10.7150/ijbs.120058
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Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects Xinyue Zhang, Jianing Wu, Zhe Zhang, Chengcheng Liu, Jing Xie
Int. J. Biol. Sci. 2025; 21(14): 6326-6350. doi:10.7150/ijbs.121559
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