1. First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, JAPAN 2. Otsuka Pharmaceutical Company, Tokushima, JAPAN 3. Department of Internal Medicine, National Cardiovascular Center, Osaka, JAPAN
✉ Correspondence to: Makoto Sata, M.D., Ph.D., Division of Pulmonology (Cardiology), Department of Internal Medicine, Laboratory of Clinical Chemistry, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565 JAPAN. TEL: +81-6-6833-5012 (ext.2311); FAX: +81-6-6872-7486; E-mail: msatancvc.go.jpMore
Citation:
Inage M, Nakamura H, Saito H, Abe S, Hino T, Takabatake N, Terashita K, Ogura M, Kato S, Hosokawa T, Sata M, Tomoike H. Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. Int J Biol Sci 2009; 5(4):304-310. doi:10.7150/ijbs.5.304. https://www.ijbs.com/v05p0304.htm
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low (n=42) or high (n=42) dose of vesnarinone. Dietary intake of vesnarinone minimized the BLM toxicity as reflected by significant decreases in numbers of inflammatory cells, KC, and soluble TNF receptors in the bronchoalveolar lavage fluid. A quantitative evaluation of histology demonstrated significantly mild lung parenchymal lesions in BLM-treated mice fed with diet containing high dose of vesnarinone than in the control diet group. Consistent with the histopathology, hydroxyproline levels in lung tissue from BLM-treated mice fed with diet containing vesnarinone were significantly lower than that from mice fed with control diet. We concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase.
Inage, M., Nakamura, H., Saito, H., Abe, S., Hino, T., Takabatake, N., Terashita, K., Ogura, M., Kato, S., Hosokawa, T., Sata, M., Tomoike, H. (2009). Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. International Journal of Biological Sciences, 5(4), 304-310. https://doi.org/10.7150/ijbs.5.304.
ACS
Inage, M.; Nakamura, H.; Saito, H.; Abe, S.; Hino, T.; Takabatake, N.; Terashita, K.; Ogura, M.; Kato, S.; Hosokawa, T.; Sata, M.; Tomoike, H. Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. Int. J. Biol. Sci. 2009, 5 (4), 304-310. DOI: 10.7150/ijbs.5.304.
NLM
Inage M, Nakamura H, Saito H, Abe S, Hino T, Takabatake N, Terashita K, Ogura M, Kato S, Hosokawa T, Sata M, Tomoike H. Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. Int J Biol Sci 2009; 5(4):304-310. doi:10.7150/ijbs.5.304. https://www.ijbs.com/v05p0304.htm
CSE
Inage M, Nakamura H, Saito H, Abe S, Hino T, Takabatake N, Terashita K, Ogura M, Kato S, Hosokawa T, Sata M, Tomoike H. 2009. Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin. Int J Biol Sci. 5(4):304-310.