Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner

Zhao, Zhengxiao; Liu, Baojun; Sun, Jing; Lu, Linwei; Liu, Lumei; Qiu, Jian; Li, Qiuping; Yan, Chen; Jiang, Shan; Mohammadtursun, Nabijan; Ma, Wenjuan; Li, Mihui; Dong, Jingcheng; Gong, Weiyi

doi:10.7150/ijbs.33146

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Theranostics

International Journal of Medical Sciences

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Int J Biol Sci 2019; 15(7):1500-1513. doi:10.7150/ijbs.33146 This issue Cite

Research Paper

Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner

Zhengxiao Zhao¹, Baojun Liu^1,2, Jing Sun^1,2, Linwei Lu^1,2, Lumei Liu^1,2, Jian Qiu^1,2, Qiuping Li^1,2, Chen Yan^1,2, Shan Jiang^1,2, Nabijan Mohammadtursun^1,2, Wenjuan Ma³, Mihui Li^1,2, Jingcheng Dong^1,✉, Weiyi Gong^1,✉

1. Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, PR China
2. Institutes of Integrative Medicine, Fudan University, Shanghai, PR China
3. Department of dermatology, Huashan Hospital, Fudan University, Shanghai, PR China

Citation:

Zhao Z, Liu B, Sun J, Lu L, Liu L, Qiu J, Li Q, Yan C, Jiang S, Mohammadtursun N, Ma W, Li M, Dong J, Gong W. Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner. Int J Biol Sci 2019; 15(7):1500-1513. doi:10.7150/ijbs.33146. https://www.ijbs.com/v15p1500.htm

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Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the world. Inhibitor of differentiation 1 (Id1) is overexpressed in NSCLC and involved in promoting its progression and metastasis. Identifying natural compounds targeting Id1 may have utility in NSCLC treatment. Here, we sought to determine whether the anti-tumor activities of Scutellaria flavonoids (SFs) were related to Id1. We reported that three SFs (baicalin, baicalein and wogonin) exhibited strong antitumor activity in NSCLC cells in vitro and in vivo. Id1 played a pivotal role on blockage of migration and invasion by SFs. Abrogation of invasion and migration mediated by baicalin, baicalein and wogonin were totally abolished by ectopic overexpression of Id1. Mechanistically, baicalin, baicalein and wogonin activated Rap1-GTP binding and dephosphorylated Akt and Src by suppressing a7nAChR, consequently triggering inhibition of Id1. Then attenuation of its downstream mediators, VEGF-A, N-cadherin, vimentin, combined with augment of E-cadherin led to the blockage of proliferation, EMT and angiogenesis of NSCLC. Overall, our data shed light on heretofore-undescribed role of SFs as modulators of Id1, which may be a useful strategy in the treatment of NSCLC.

Keywords: inhibitor of differentiation 1 (Id1), scutellaria flavonoids (SFs), non-small cell lung cancer (NSCLC), alpha 7 nicotinic acetylcholine receptor (α7nAChR)

Citation styles

APA

Zhao, Z., Liu, B., Sun, J., Lu, L., Liu, L., Qiu, J., Li, Q., Yan, C., Jiang, S., Mohammadtursun, N., Ma, W., Li, M., Dong, J., Gong, W. (2019). Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner. International Journal of Biological Sciences, 15(7), 1500-1513. https://doi.org/10.7150/ijbs.33146.

ACS

Zhao, Z.; Liu, B.; Sun, J.; Lu, L.; Liu, L.; Qiu, J.; Li, Q.; Yan, C.; Jiang, S.; Mohammadtursun, N.; Ma, W.; Li, M.; Dong, J.; Gong, W. Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner. Int. J. Biol. Sci. 2019, 15 (7), 1500-1513. DOI: 10.7150/ijbs.33146.

NLM

CSE

Zhao Z, Liu B, Sun J, Lu L, Liu L, Qiu J, Li Q, Yan C, Jiang S, Mohammadtursun N, Ma W, Li M, Dong J, Gong W. 2019. Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner. Int J Biol Sci. 15(7):1500-1513.

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