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Volume 22 (2); 2026
Editorial
Virtual lab of artificial intelligence agents accelerating nanobody design against SARS-CoV-2 variants Hakjin Kim, Taeho Kwon, Sun-Uk Kim, Seon-Kyu Kim
Int. J. Biol. Sci. 2026; 22(2): 618-621. doi:10.7150/ijbs.126093
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Research Papers
Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population Lothar Hennighausen, Gyuhyeok Cho, Sung-Gwon Lee, Yasmin Caf, Jungwook Kim, Ludwig Knabl, Priscilla A. Furth, Hye Kyung Lee
Int. J. Biol. Sci. 2026; 22(2): 519-528. doi:10.7150/ijbs.124098
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AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells Hanah Lim, Seonock Lee, Gamin Kim, Eun Joo Lee, Jungho Kim
Int. J. Biol. Sci. 2026; 22(2): 529-552. doi:10.7150/ijbs.116651
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Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors Jae Soon Kang, Ji Hyeong Baek, Hyeongchan Park, Naveed Ur Rehman, Hye Jin Chung, Dong Kun Lee, Sekyung Oh, Hyun Joon Kim
Int. J. Biol. Sci. 2026; 22(2): 553-565. doi:10.7150/ijbs.123740
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Hepatic Aquaporin 8 Promotes Alcohol Consumption and Ameliorates Alcohol-Induced Liver Injury by Facilitating Acetaldehyde Excretion Cheng Chen, Yu-Hong Lin, Dechun Feng, Yukun Guan, Yaojie Fu, Yang Wang, Luca Maccioni, Deniz Seyhan, Tiantian Yao, Shoupeng Wei, Li Zhang, George Kunos, Bryan Mackowiak, Bin Gao
Int. J. Biol. Sci. 2026; 22(2): 566-581. doi:10.7150/ijbs.122713
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Dual Phosphorylation of STAT1 at Y701/S727 by TNFα Drives AIM2-Mediated PANoptosis of Renal Tubular Epithelial Cells and Fibrotic Progression in Renal Allografts Qianguang Han, Jiawen Liu, Jianjian Zhang, Qinghuan Shen, Junqi Zhang, Shuang Fei, Hao Chen, Li Sun, Zhengkai Huang, Zhijian Han, Jun Tao, Min Gu, Xiaobing Ju, Ruoyun Tan
Int. J. Biol. Sci. 2026; 22(2): 582-600. doi:10.7150/ijbs.123441
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IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization Rui Chen, Yi-xun Li, Wei-lin Lu, Ke-fei Wu, Yu-xin Wang, Zi-wen Wang, Yi-han Li, Hai-yan Yang, Xu Zhang, Liang Shi, Dong Zhou, Ying Wang, Qiang Ding
Int. J. Biol. Sci. 2026; 22(2): 622-640. doi:10.7150/ijbs.121503
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Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer Meng-Yao Xu, Sheng Ma, Si-Yang Ma, Chen-Qian Liu, Jian-Xuan Sun, Ye An, Jin-Zhou Xu, Si-Han Zhang, Na Zeng, Xing-Yu Zhong, Xiao-Hua Zhu, Shao-Gang Wang, Qi-Dong Xia
Int. J. Biol. Sci. 2026; 22(2): 641-662. doi:10.7150/ijbs.120760
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PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma Taian Jin, Jiahui Ma, Luping Wang, Xinbo Liu, Mengting Wu, Binqi Wang, Chan Gao, Siqi Zhu, Ruikai Zhang, Fanwei Xia, Jingkui Tian, Wei Zhu, Juan Jin, Qiang He
Int. J. Biol. Sci. 2026; 22(2): 663-683. doi:10.7150/ijbs.122418
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DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR Ying Liu, Yangyang Li, Xiaowei Quan, Jiayi Zhang, Zhicong Wang, Zhaoyuan Hou, Herbert Yu, Haipeng Liu, Tengteng Zhu, Biyun Qian
Int. J. Biol. Sci. 2026; 22(2): 684-700. doi:10.7150/ijbs.112100
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rBCG-LTAK63 Outperforms BCG in Bladder Cancer Immunotherapy: Dendritic and T Cell Coordination Drives Superior Tumor Control in a Mouse Model Matheus Ferreira de Almeida, Bruna Gennari Rosa, Daniela Delechiave, Lucas Francisco Annequin, Lazaro Moreira Marques-Neto, Monalisa Martins Trentini, Johanna Christine van Vliet, Isabelle Carolina Cotrim Gozzi, Ana Carolina de Oliveira Carvalho, Dunia Rodriguez, Lennon Ramos Pereira, Giana Carla Gaboardi, Luís Carlos de Souza Ferreira, Luciana Cezar de Cerqueira Leite, Ana Carolina Ramos Moreno
Int. J. Biol. Sci. 2026; 22(2): 713-730. doi:10.7150/ijbs.118329
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Parkin Deficiency Impairs ER-Mitochondria Associations and calcium homeostasis via IP3R-Grp75-VDAC1 Complex Nai-Jia Xue, Yi Liu, Zhi-Hao Lin, Wen-Hao Huang, Feng Zhang, Ran Zheng, Xiao-Li Si, Lu-Yan Gu, Yi Fan, Jia-Li Pu, Bao-Rong Zhang
Int. J. Biol. Sci. 2026; 22(2): 731-749. doi:10.7150/ijbs.121759
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Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages Yuanyuan Cheng, Ni Fan, Xiuying Zhang, Wei Zhao, Baoping Xie, Jia Zhao, Marlene Rong, Xuechen Li, Hung-Fat Tse, Jianhui Rong
Int. J. Biol. Sci. 2026; 22(2): 771-785. doi:10.7150/ijbs.116671
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GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis Dongxue Gan, Cheng Yang, Xiangjing Shen, Jingjie Shi, Ronglin Wang, Liaoliao Zhu, Hong Li, Jing Luo, Ting Zhao, Junqiang Li, Yang Song, Haichuan Su
Int. J. Biol. Sci. 2026; 22(2): 786-801. doi:10.7150/ijbs.119064
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Extracellular vesicles derived from irradiated tumor cells foster immunosuppressive macrophages formation to promote esophageal squamous cell carcinoma immune evasion Shanshan Jiang, Yechun Pang, Yue Zhou, Jianjiao Ni, Li Chu, Xiao Chu, Jianghong Zhang, Yan Pan, Yida Li, Ruiting Ye, Hongru Chen, Silai Yu, Tiantian Guo, Chunlin Shao, Xi Yang, Zhengfei Zhu
Int. J. Biol. Sci. 2026; 22(2): 802-822. doi:10.7150/ijbs.123646
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Zinc-Induced PKCδ-dependent Phosphorylation of MTF-1 Promotes Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension Ai Chen, Yan Yan, Rong Cao, Kexin Cai, Guili Lian, Wenqin Cai, Jianfu Zhou, Liangdi Xie
Int. J. Biol. Sci. 2026; 22(2): 823-840. doi:10.7150/ijbs.124664
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ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming Sibei Tao, Chenzhou Wu, Fanyuan Yu, Lina Yang, Lingzhi Li, Fan Guo, Ting Xiang, Liang Ma, Ping Fu
Int. J. Biol. Sci. 2026; 22(2): 841-857. doi:10.7150/ijbs.125062
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NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1 Wu Ye, Yigang Li, Wei Wang, Dishui Pan, Xiaokun Wang, Yao Gu, Yufeng Zhu, Haofan Wang, Xuanyu Lu, Dongdong Jiang, Pengyu Tang, Haoming Shu, Jun Ma, Weihua Cai
Int. J. Biol. Sci. 2026; 22(2): 858-875. doi:10.7150/ijbs.123639
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Hepatocyte SAMHD1 Deficiency Attenuates Hepatic Steatosis via Suppression of SREBP Activation in a Mouse Model of Metabolic-Associated Steatotic Liver Disease Guangfa Yin, Yongqing Liu, Xianhe Teng, Shuqi Sun, Beibei Chen, Xinyu Wang, Tao Yang, Ying Wang, Hanyang Xu, Yu-sheng Chen, Guowei Gan, Yuxian Shen, Juntang Shao
Int. J. Biol. Sci. 2026; 22(2): 876-894. doi:10.7150/ijbs.125688
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Excessive Kynurenine Metabolism Impairs Lysosomal acidification and Triggers mtDNA Release via the AHR/CISH/ATP6V1A Axis in Decidual Macrophages Associated with Unexplained Recurrent Pregnancy Loss Guangmin Song, Hongli Li, Man Zhang, Yun Li, Xinyi Tao, Andi Wang, Jianqi Wang, Boris Novakovic, Richard D. Cannon, Richard Saffery, Hongbo Qi, Hua Zhang, Xiaobo Zhou
Int. J. Biol. Sci. 2026; 22(2): 895-919. doi:10.7150/ijbs.121947
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Gut Metabolite Indoleacrylic Acid Suppresses Osteoclast Formation by AHR mediated NF-κB Signaling Pathway Jinwu Bai, Gao Si, Ruideng Wang, Shilong Su, Jixing Fan, Xi He, Yang Lv, Shan Gao, Fang Zhou
Int. J. Biol. Sci. 2026; 22(2): 951-969. doi:10.7150/ijbs.124766
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Co-targeting MRPS7-23 synergistically enhances cisplatin efficacy to suppress nasopharyngeal carcinoma growth and metastasis Zhangqi Cao, Can Pan, Zeyu Liu, Qi Quan, Mengping Li, Yu Huang, Chuwen Liang, Yuwen Chen, Teng Fan, Ping Chen, Fu Kai, Shuangli Zhu, Sijia Li, Xin Su, Fang Wang, Liwu Fu, Bei Zhang
Int. J. Biol. Sci. 2026; 22(2): 970-994. doi:10.7150/ijbs.115523
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Apoptotic Cancer Cell-Primed Cancer-Associated Fibroblasts Suppress Immunosuppressive Macrophages via WISP-1-Integrin α5β3-STAT1 Signaling in Lung Cancer Kyungwon Yang, Kiyoon Kim, Hee Ja Kim, Jeesoo Chae, Ye-Ji Lee, Shinyoung Kim, Young-Ho Ahn, Jihee Lee Kang
Int. J. Biol. Sci. 2026; 22(2): 995-1015. doi:10.7150/ijbs.124282
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RSPO4 exerts tumor suppression through antagonizing canonical and non-canonical Wnt signaling Zhenfang Du, Lili Li, Xingsheng Shu, Chen Li, Qian Tao
Int. J. Biol. Sci. 2026; 22(2): 1016-1035. doi:10.7150/ijbs.124734
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USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization Huizhuang Shan, Youping Zhang, Xinhua Xiao, Wenxuan Wu, Yingying Wang, Chujiao Zhu, Wenhui Bai, Ziwei Zhang, Yuanhui Zhai, Li Yang, Yunzhao Wu, Hu Lei, Hanzhang Xu, Yanfei Luo, Liming Lu, Yingli Wu
Int. J. Biol. Sci. 2026; 22(2): 1036-1052. doi:10.7150/ijbs.123712
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Reviews
Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders Li Xu, Chen Shen, Xin Liu, Yi Qin, Zebin Wu, Ziyu Zhang, Qifeng Sheng, Qihan Wang, Feng Zhou, Gaoran Ge, Dechun Geng
Int. J. Biol. Sci. 2026; 22(2): 601-617. doi:10.7150/ijbs.125544
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The Role of Hedgehog Signaling in Non-small Cell Lung Cancer: Targeting Tumor Invasion, Therapy Resistance and Novel Therapeutic Strategies Yu Kang, Hongmei Zheng, Qiuyuan Wen, Songqing Fan
Int. J. Biol. Sci. 2026; 22(2): 701-712. doi:10.7150/ijbs.123287
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Microbiota-gut-kidney axis in health and renal disease Ying Jin, Shui-Juan Zhang, Shougang Zhuang, Ping Li, Hua Miao, Ying-Yong Zhao
Int. J. Biol. Sci. 2026; 22(2): 750-770. doi:10.7150/ijbs.125140
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RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities Zeyu Wu, Yuncan Xing, Shiwen Mei, Tixian Xiao, Fangze Wei, Qian Liu
Int. J. Biol. Sci. 2026; 22(2): 920-950. doi:10.7150/ijbs.124177
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