International Journal of Biological Sciences
ISSN: 1449-2288
10
Impact Factor
ISSN: 1449-2288
Global reach, higher impactVolume 22 (4); 2026
Research Papers
NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells
Mickaëlle Radom, Camille Buffet, Juliana Cazarin, Marylin Harinquet, Caroline Coelho de Faria, Floriane Brayé, Catline Nobre, Marine Aglave, Yasmina Mesloub, Thibault Dayris, Nathalie Droin, Karine Godefroy, Mohamed-Amine Bani, Abir Al Ghuzlan, Sophie Leboulleux, Livia Lamartina, Corinne Dupuy
Int. J. Biol. Sci. 2026; 22(4): 1674-1692. doi:10.7150/ijbs.123980
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The SOX10-ACAT2-Cholesterol Synthesis Axis Is Required for Melanoma Proliferation
Lihua Wang, Chenyuan Dai, Jie Yang, Yawen Ma, Xia Ding, Xianqun Fan
Int. J. Biol. Sci. 2026; 22(4): 1717-1732. doi:10.7150/ijbs.114084
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Clusterin Inhibits Neuronal Ferroptosis via the PI3K-AKT-mTOR-SREBP1 Axis to Promote Functional Recovery after Spinal Cord Injury
Senyu Yao, Ziming Wang, Xiaokang Wang, Yangfan Yu, Xu Huang, Liqi Chen, Zhenming Tian, Bin Liu, Yang Yang, Mao Pang, Limin Rong
Int. J. Biol. Sci. 2026; 22(4): 1733-1751. doi:10.7150/ijbs.124291
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Inhibition of Cathepsin B protects against vandetanib-induced hepato-cardiotoxicity by restoring lysosomal damage
Wentong Wu, Jiangxia Du, Jinjin Li, Shaoyin Zhang, Xingchen Kang, Yashi Cao, Jian Chen, Zengyue Pan, Xiangliang Huang, Zhifei Xu, Bo Yang, Qiaojun He, Xiaochun Yang, Hao Yan, Peihua Luo
Int. J. Biol. Sci. 2026; 22(4): 1752-1774. doi:10.7150/ijbs.122904
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Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease
Siman Shen, Chen Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li Xu
Int. J. Biol. Sci. 2026; 22(4): 1775-1792. doi:10.7150/ijbs.126011
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FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis
Yaner Wang, Yali Wang, Yaoli Cui, Yuanming He, Ye Yang, Wen Zhou, Longlong Liu, Hua Wang, Mo Liu, Yongqiang Wei, Zhenqian Huang, Xiaolei Wei, Xinliang Mao
Int. J. Biol. Sci. 2026; 22(4): 1793-1806. doi:10.7150/ijbs.124782
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FKBP10 promotes M2 polarization of macrophage via MEK/ERK/CXCL8 axis and facilitates tumor progression in clear cell renal cell carcinoma
Jin-Wei Chen, Jia-Ying Li, Hao-Qian Feng, Liang-Min Fu, Xin-Wei Zhou, Han-Sen Lin, Ying-Han Wang, Ke-Zhi Liu, Yu-Hang Chen, Zhu Wang, Qiong Deng, Jie-Yan Wang, Mei-Yu Jin, Hui Liang, Jin-Huan Wei, Jun-Hang Luo, Cheng-Peng Gui
Int. J. Biol. Sci. 2026; 22(4): 1807-1833. doi:10.7150/ijbs.117535
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Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling
Handi Li, Shuo Zhang, Chen Feng, Fangyan Cheng, Yuanyuan Han, Mengxue Wang, Shuai Zhou, Wenbo Shao, Wenzhong Chen, Jingguo Chen, Kai Liu, Yingze Zhang, Juan Wang
Int. J. Biol. Sci. 2026; 22(4): 1834-1851. doi:10.7150/ijbs.124507
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ATMLP Enhances Radioresistance in Non-Small Cell Lung Cancer through AKT-Mediated Lipid Droplet Accumulation
Yingchu Dai, Wanyi Wu, Tingyu Jiao, Lu Hou, Wanshi Li, Jiyuan Liu, Qianjiale Gu, Fengtao Su, Jing Nie, Bingyan Li, Jing Wang, Hailong Pei, Guangming Zhou
Int. J. Biol. Sci. 2026; 22(4): 1852-1867. doi:10.7150/ijbs.116401
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Review
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response
Michal Stark, Yehuda G. Assaraf
Int. J. Biol. Sci. 2026; 22(4): 1693-1716. doi:10.7150/ijbs.127929
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