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Volume 22 (4); 2026
Research Papers
NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells Mickaëlle Radom, Camille Buffet, Juliana Cazarin, Marylin Harinquet, Caroline Coelho de Faria, Floriane Brayé, Catline Nobre, Marine Aglave, Yasmina Mesloub, Thibault Dayris, Nathalie Droin, Karine Godefroy, Mohamed-Amine Bani, Abir Al Ghuzlan, Sophie Leboulleux, Livia Lamartina, Corinne Dupuy
Int. J. Biol. Sci. 2026; 22(4): 1674-1692. doi:10.7150/ijbs.123980
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The SOX10-ACAT2-Cholesterol Synthesis Axis Is Required for Melanoma Proliferation Lihua Wang, Chenyuan Dai, Jie Yang, Yawen Ma, Xia Ding, Xianqun Fan
Int. J. Biol. Sci. 2026; 22(4): 1717-1732. doi:10.7150/ijbs.114084
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Clusterin Inhibits Neuronal Ferroptosis via the PI3K-AKT-mTOR-SREBP1 Axis to Promote Functional Recovery after Spinal Cord Injury Senyu Yao, Ziming Wang, Xiaokang Wang, Yangfan Yu, Xu Huang, Liqi Chen, Zhenming Tian, Bin Liu, Yang Yang, Mao Pang, Limin Rong
Int. J. Biol. Sci. 2026; 22(4): 1733-1751. doi:10.7150/ijbs.124291
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Inhibition of Cathepsin B protects against vandetanib-induced hepato-cardiotoxicity by restoring lysosomal damage Wentong Wu, Jiangxia Du, Jinjin Li, Shaoyin Zhang, Xingchen Kang, Yashi Cao, Jian Chen, Zengyue Pan, Xiangliang Huang, Zhifei Xu, Bo Yang, Qiaojun He, Xiaochun Yang, Hao Yan, Peihua Luo
Int. J. Biol. Sci. 2026; 22(4): 1752-1774. doi:10.7150/ijbs.122904
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Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease Siman Shen, Chen Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li Xu
Int. J. Biol. Sci. 2026; 22(4): 1775-1792. doi:10.7150/ijbs.126011
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FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis Yaner Wang, Yali Wang, Yaoli Cui, Yuanming He, Ye Yang, Wen Zhou, Longlong Liu, Hua Wang, Mo Liu, Yongqiang Wei, Zhenqian Huang, Xiaolei Wei, Xinliang Mao
Int. J. Biol. Sci. 2026; 22(4): 1793-1806. doi:10.7150/ijbs.124782
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FKBP10 promotes M2 polarization of macrophage via MEK/ERK/CXCL8 axis and facilitates tumor progression in clear cell renal cell carcinoma Jin-Wei Chen, Jia-Ying Li, Hao-Qian Feng, Liang-Min Fu, Xin-Wei Zhou, Han-Sen Lin, Ying-Han Wang, Ke-Zhi Liu, Yu-Hang Chen, Zhu Wang, Qiong Deng, Jie-Yan Wang, Mei-Yu Jin, Hui Liang, Jin-Huan Wei, Jun-Hang Luo, Cheng-Peng Gui
Int. J. Biol. Sci. 2026; 22(4): 1807-1833. doi:10.7150/ijbs.117535
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Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling Handi Li, Shuo Zhang, Chen Feng, Fangyan Cheng, Yuanyuan Han, Mengxue Wang, Shuai Zhou, Wenbo Shao, Wenzhong Chen, Jingguo Chen, Kai Liu, Yingze Zhang, Juan Wang
Int. J. Biol. Sci. 2026; 22(4): 1834-1851. doi:10.7150/ijbs.124507
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ATMLP Enhances Radioresistance in Non-Small Cell Lung Cancer through AKT-Mediated Lipid Droplet Accumulation Yingchu Dai, Wanyi Wu, Tingyu Jiao, Lu Hou, Wanshi Li, Jiyuan Liu, Qianjiale Gu, Fengtao Su, Jing Nie, Bingyan Li, Jing Wang, Hailong Pei, Guangming Zhou
Int. J. Biol. Sci. 2026; 22(4): 1852-1867. doi:10.7150/ijbs.116401
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HAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in Glioblastoma Yuzu Zhao, Jiang He, Zhiying Zhou, Tangmin Lai, Siwei Zeng, Nan Li, Yu He, Wei Zhou, Yongzhong Wu, Bo Xu
Int. J. Biol. Sci. 2026; 22(4): 1906-1919. doi:10.7150/ijbs.125306
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Irf7 Deficiency Confers Protection Against Influenza Infection, Independent of irf3 Jianzhou Cui, Sherman S. W. Foo, Wan Ting Kong, Chenshi Lin, Patrick B. Ampomah, Olga Zharkova, Loo Soon Chai, Karishma Sachaphibulkij, Suruchi Arora, Nivashini Kaliaperumal, Hong Meng Lim, John Connolly, Anna-Marie Fairhurst, Jinmiao Chen, Lina H. K. Lim
Int. J. Biol. Sci. 2026; 22(4): 1974-1996. doi:10.7150/ijbs.126714
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CXCR4 inhibition alleviates prostatic inflammation and pelvic pain via suppressing Th17 cell differentiation and oxidative stress in EAP mice Yongtao Hu, Yi Liu, Jialin Meng, Ruijie Hu, Wenming Ma, Wenlong Xu, Kun Tang, Xianchao Dou, Chaozhao Liang, Li Zhang, Jing Chen
Int. J. Biol. Sci. 2026; 22(4): 2027-2046. doi:10.7150/ijbs.124532
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AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cell Function via TNF-α-FBP2 Signaling Lisha Zhu, Yu Wang, Xinmeng Shi, Min Yu, Xinjia Cai, Liyuan Chen, He Zhang, Xiaolan Wu, Chengye Ding, Hangbo Liu, Shiying Zhang, Chang Li, Tianhao Wu, Nan Jiang, Yan Liu
Int. J. Biol. Sci. 2026; 22(4): 2047-2064. doi:10.7150/ijbs.125245
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Rubimaillin ameliorates liver fibrosis by triggering the ferroptosis of activated hepatic stellate cells through targeting CPT1A Dingqi Zhang, Qingxuan Tang, Xiaoli He, Chengming Wen, Fengfeng Zhou, Xia Wei, Zikang Wang, Jiao Wang, Wei Liu, Ying Xu, Yunyao Jiang, Hang Yin
Int. J. Biol. Sci. 2026; 22(4): 2065-2084. doi:10.7150/ijbs.120415
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Targeted Induction of Cancer Cell Necroptosis Potentiates Anti-PD-1 Immunotherapy via CD80 Activation Xu Zhang, Detian Zhang, Zhe Zhou, Waner Liu, Susi Zhu, Siyu Xiong, Xiang Chen, Cong Peng
Int. J. Biol. Sci. 2026; 22(4): 2085-2100. doi:10.7150/ijbs.121690
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TRPV1 Downregulation Impairs Prostate Cancer Growth: Functional and Translational Insights from Cellular and In Vivo Models Belén G. Sánchez, José M. Mora-Rodríguez, Alicia Bort, Ana Palacín, Carlos Sánchez-Rodríguez, Manuel Sánchez-Chapado, Julie Courraud, Jerome Zoidakis, Inés Díaz-Laviada
Int. J. Biol. Sci. 2026; 22(4): 2101-2120. doi:10.7150/ijbs.125429
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Human umbilical cord mesenchymal stem cell delivery of mitochondria to melanocytes enhances skin repigmentation efficacy in autologous epidermal cell suspension transplantation through the TNFAIP2-TNT system Xiaodong Jin, Shishi Xiong, Bo Wang, Qi Wang, Jia Zhang, Zeqian Wang, Yuqi Zhou, Xiaoqi Chen, Tong Wu, Shanshan Gao, Chenxi Zhang, Qing Zhang, Yucheng Sun, Zhe Jian
Int. J. Biol. Sci. 2026; 22(4): 2135-2156. doi:10.7150/ijbs.128719
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CCL24 recruits CCR3+ TAMs to promote immunosuppression via YAP1 activation and serves as a therapeutic target for Gracillin in colorectal cancer Shiyu Huang, Wanqiong Lin, Xu Ding, Jinjun Shi, Fei Liu, Guoqing Wang, Chanchan Gao, Xiangyu Su
Int. J. Biol. Sci. 2026; 22(4): 2157-2176. doi:10.7150/ijbs.127341
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NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17 Yuting Zhu, Wenchao Xu, Cheng Wan, Bowen Deng, Yaru Xie, Bin Yang, Hongyang Jiang, Chun Zhang
Int. J. Biol. Sci. 2026; 22(4): 2177-2195. doi:10.7150/ijbs.127909
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Reviews
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response Michal Stark, Yehuda G. Assaraf
Int. J. Biol. Sci. 2026; 22(4): 1693-1716. doi:10.7150/ijbs.127929
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Post-translational modifications in ferroptosis: mechanisms and therapeutic potential Xiaoting Xie, Qianghu Pang, Lianxiang Luo
Int. J. Biol. Sci. 2026; 22(4): 1868-1905. doi:10.7150/ijbs.120624
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Reprogrammed Fibrotic Niche Fuels Lung Cancer Initiation and Reciprocal Remodeling Zhufeng Hu, Wu Dan, Mengran Xi, Zhengyuan Fang, Kunlun Feng, Jie Mei, Zhang Ting, Baojun Liu, Zhiwen Luo
Int. J. Biol. Sci. 2026; 22(4): 1920-1949. doi:10.7150/ijbs.127307
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Metabolic Checkpoints in CD8+ T Cells within the Tumor Microenvironment: A Comprehensive Review and Emerging Insights Jiaqi Ai, Yiheng Du, Qianqian Xue, Wenbei Peng, Qiong Zhou
Int. J. Biol. Sci. 2026; 22(4): 1950-1973. doi:10.7150/ijbs.125206
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Epigenetic Reprogramming of Erythroid Progenitor Cells: Insights for Enhancing Cancer Immunotherapy Zi-Zhan Li, Xuan-Yu Su, Cheng-Ke Zhou, Su-Ran Li, Zhi-Jun Sun
Int. J. Biol. Sci. 2026; 22(4): 1997-2011. doi:10.7150/ijbs.127543
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O-glycosylation in Cancer: Emerging Paradigms and Prospects for Precision Oncology Junhao Wei, Shengbao Hu, Wanfang Chen, Hye Song Paek, Guohong Liu, Yunbao Pan
Int. J. Biol. Sci. 2026; 22(4): 2012-2026. doi:10.7150/ijbs.126296
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Commentaries
Spatial Pharmacology: Redefining Organelle Contact Sites as Therapeutic Targets Minjeong Ko, Jiho You, Eunwoo Cho, Ho Jeong Kwon
Int. J. Biol. Sci. 2026; 22(4): 2121-2123. doi:10.7150/ijbs.129515
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Data-driven de novo design: revolutionizing super-adhesive hydrogels for underwater applications Ying Cen, Xue-miao Liu, Zhi-Qiang Song, Hong-Juan Fang, Xing Wang
Int. J. Biol. Sci. 2026; 22(4): 2124-2126. doi:10.7150/ijbs.128485
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Comment on "Dectin-1 is Pathogenic in Chronic Kidney Disease by Promoting Macrophage Infiltration and Transition to Myofibroblast" Dequan Liu, Xiangyu Che, Guangzhen Wu
Int. J. Biol. Sci. 2026; 22(4): 2127-2128. doi:10.7150/ijbs.125175
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Galectin-3 in AKI: Pathogenic Target, Diagnostic Biomarker, or Both? Yuan Gui, Dong Zhou
Int. J. Biol. Sci. 2026; 22(4): 2129-2131. doi:10.7150/ijbs.129063
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LAV-BPIFB4 reverses progeria-associated cardiac aging by restoring diastolic function and reducing senescence Unbin Chae, Young-Ho Park, Taeho Kwon, Kyung-Sook Chung, Sun-Uk Kim
Int. J. Biol. Sci. 2026; 22(4): 2132-2134. doi:10.7150/ijbs.129092
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