Volume 22, Issue 3

open access Global reach, higher impact

Volume 22 (3); 2026

Research Papers

β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice
E. Sandra Chocron, David Zhang, Bushra Sumawi, Joseph Schell, Diego Cruz, Guannan Li, Prethish Sreenivas, Haiyan Jiang, Felix F. Dong, Erin Munkácsy, Shangang Zhao, Maria A. Gonzalez Porras, David Gius
Int. J. Biol. Sci. 2026; 22(3): 1070-1081. doi:10.7150/ijbs.122643
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Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma
Hay-Ran Jang, Hyun-Jin Kim, Bo-Young Kim, Jae-Hoon Jeong, Jeon-Kyung Kim, Jin Ah Won, Hye Hyun Yoo, Yong Gu Lee, Hyungshin Yim
Int. J. Biol. Sci. 2026; 22(3): 1082-1102. doi:10.7150/ijbs.118753
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TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease
Eun-Ae Shin, Haesong Lee, Kyung-hee Pyo, Wonsik Kim, Soyeon Kim, Jae-Ho Lee, Seo Hee Jin, Eunmi Kim, Soo-Min Byeon, Dong Joo Kim, Young Jun Cho, Tae Won Kim, Minjae Ohn, Hyojung Lee, Jeongwon Lee, Jinwook Jeong, Doojin Kim, Jie Zheng, Han Ah Lee, Hwi Young Kim, Young-Joon Surh, Jung Weon Lee
Int. J. Biol. Sci. 2026; 22(3): 1103-1125. doi:10.7150/ijbs.126251
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Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer
Ágata Sofia Assunção Carreira, Marianna Ciuffreda, Nathakan Thongon, Charles M. Haughey, Adam Pickard, Sharon L. Eddie, Rebecca E. Steele, Elena Cerri, Romina Belli, Daniele Peroni, Elisa Facen, Irene Caffa, Moustafa Ghanem, Alessio Nencioni, Andrea Lunardi, Toma Tebaldi, Ian G. Mills, Alessandro Provenzani
Int. J. Biol. Sci. 2026; 22(3): 1126-1141. doi:10.7150/ijbs.120532
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Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation
Hong Ding, Wen-Xuan Wang, Qiong-Dan Liang, Chuan-Feng Tang, Tang-Di Xu, Zi-An Miao, Bang-Xing Han, Ling-Dong Kong
Int. J. Biol. Sci. 2026; 22(3): 1162-1185. doi:10.7150/ijbs.120307
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Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression
Mingshu Long, Yang Chen, Ruixue Du, Jiejie Yang, Jingjing Wang, Yunqing Sun, Xuezhang Tian, Shaowei Wang, Yunhong Zhong, Weilian Liang, Junjie Zhang, Zhengjun Shang
Int. J. Biol. Sci. 2026; 22(3): 1186-1206. doi:10.7150/ijbs.123790
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Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury
Xue Zhou, Xian Fu, Yi-Wen Meng, Ping Dai, Qing Jiang, Hou-Hua Yin, Qing-Jin Pan, Ai-Zhi Lin, Kai-Di Ni, Zi-Guo Luo, Ru-Yu Liang, Yi-Yu Chen, Hai-Xin Yuan, Jun-Yan Liu
Int. J. Biol. Sci. 2026; 22(3): 1247-1265. doi:10.7150/ijbs.125930
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Targeting c-Myc-p300-CARM1 complex induces ferroptosis and reduces CD8⁺ T cell exhaustion in esophageal squamous cell carcinoma
Yuhao Wang, Yang Li, Guanzhu Ren, Jin Zhou, Wangtianjiao Chen, Kai Zhang, Xiao Yu, Yin Yin, Ji Cong, Lei Ma, Xinyao Zheng, Yahui Zhao, Zhihua Liu
Int. J. Biol. Sci. 2026; 22(3): 1266-1282. doi:10.7150/ijbs.114575
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Sema3d^hi Fibroblasts Promote Acute Kidney Injury Fibrotic Progression Through Confining Endothelial Cell Migration
Qiuyu Xie, Xiaohong Xin, Weijian Yao, Zehua Li, Yuanyuan Ma, Lei Qu, Yiyi Ma, Chengang Xiang, Suxia Wang, Gang Liu, Ying Chen, Li Yang
Int. J. Biol. Sci. 2026; 22(3): 1283-1305. doi:10.7150/ijbs.124971
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Loss of UFL1 confers enzalutamide resistance of prostate tumors by regulating METTL16-mediated m6A modification of EEF1A1 mRNA
Xu Wu, Hui Gao, Qianfeng Zhuang, Feng Li, Xingliang Feng, Naiyuan Shao, Wei Zhang, Yuyang Zhang, Xiansheng Zhang
Int. J. Biol. Sci. 2026; 22(3): 1306-1321. doi:10.7150/ijbs.124214
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Reviews

Microbiota-Gut-Kidney Axis and Targeted Therapeutic Strategies in Kidney Diseases
Zheng-hao Sun, Qian Gong, Zi-lai Wang, Chao Li, Jia-nan Wang, Ju-tao Yu, Ming-lu Ji, Dan-feng Zhang, Jie Wei, Shuai-shuai Xie, Fang-jie Zhou, Xiang-yu Li, Xiao-guo Suo, Qi Zhu, Juan Jin, Wei Shao, Pei Pan, Xiao-ming Meng
Int. J. Biol. Sci. 2026; 22(3): 1142-1161. doi:10.7150/ijbs.124499
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The Role of Estrogen Signaling Pathway and Targeted Therapy Exploration in Urological Tumors
Cunzhen Ma, Lin Yang, Weijia Li, Wentai Shangguan, Wenxue Huang, Zhuohang Li, Boyuan Sun, Xunguo Yang, Haoxiang Xu, Zhibiao Li, Peidan Peng, Zongwei Wang, Peng Wu, Bisheng Cheng
Int. J. Biol. Sci. 2026; 22(3): 1207-1232. doi:10.7150/ijbs.123812
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Exploring huntington's disease from a neurodevelopmental perspective
Chunhui Huang, Xiao Zheng, Wei Li, Zaijun Zhang, Shihua Li, Xiao-Jiang Li, Mingdeng Rong, Sen Yan
Int. J. Biol. Sci. 2026; 22(3): 1233-1246. doi:10.7150/ijbs.124552
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The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies
Xu Zhang, Zhiqiang Zhang, Qian Peng, Xinyu Huang, Mengyuan Liu, Daoming Bai, Rui Yang, Yun Zhang, Chunping Yang
Int. J. Biol. Sci. 2026; 22(3): 1322-1345. doi:10.7150/ijbs.126788
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