1. ENT Hospital of Shenzhen University School of Medicine, Longgang ENT Hospital, Shenzhen, China.
2. Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
3. Department of Otolaryngology, Head & Neck Surgery, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
4. Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
*Equally contributed to this work.
✉ Corresponding author: Dr. Ping-Chang Yang (firstname.lastname@example.org) and Dr. Zhi-Gang Liu (email@example.com). Room A7-507 at Xili Campus, Shenzhen University School of Medicine. 1066 Xueyuan Blvd, Shenzhen 518055, China. Tel: 8675586172722. Fax: 8675586671906.
Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in the alleviation of experimental AR.
Methods: Peripheral blood samples were obtained from AR patients. Serum levels of sCD83 were determined by enzyme-linked immunosorbent assay. A murine AR model was developed to test the effects of sCD83 on suppressing experimental AR.
Results: We found that serum levels of sCD83 in the AR group were lower than that in the healthy control group. A negative correlation was identified between the serum sCD83 levels and the frequency of T helper-2 (Th2) cells. The low serum sCD83 levels were also associated with the Bcl2L12 expression in antigen-specific Th2 cells. Exposure to sCD83 enhanced the responsiveness of antigen-specific Th2 cells to apoptosis inducers via suppressing the Bcl2L12 expression. Administration of sCD83 efficiently suppressed experimental AR.
Conclusions: sCD83 contributes to immune homeostasis by regulating CD4+ T cell activities. Administration of sCD83 may have translational potential for the treatment of AR or other allergic diseases.
Keywords: Allergy, nasal mucosa, CD83, CD4+ T cell, immune regulation