ISSN: 1449-2288International Journal of Biological Sciences
Global reach, higher impact
Int J Biol Sci 2020; 16(9):1575-1585. doi:10.7150/ijbs.41852 This issue Cite
Review
STAT4: an immunoregulator contributing to diverse human diseases
State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, GuangZhou, China.
Citation:
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci 2020; 16(9):1575-1585. doi:10.7150/ijbs.41852. https://www.ijbs.com/v16p1575.htm
Other stylesAbstract
Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression. We reviewed the essential role played by STAT4 in a wide variety of cells and the pathogenesis of diverse human diseases, especially many kinds of autoimmune and inflammatory diseases, via activation by different cytokines through the Janus kinase (JAK)-STAT signaling pathway.
Citation styles
APA
Yang, C., Mai, H., Peng, J., Zhou, B., Hou, J., Jiang, D. (2020). STAT4: an immunoregulator contributing to diverse human diseases. International Journal of Biological Sciences, 16(9), 1575-1585. https://doi.org/10.7150/ijbs.41852.
ACS
Yang, C.; Mai, H.; Peng, J.; Zhou, B.; Hou, J.; Jiang, D. STAT4: an immunoregulator contributing to diverse human diseases. Int. J. Biol. Sci. 2020, 16 (9), 1575-1585. DOI: 10.7150/ijbs.41852.
NLM
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci 2020; 16(9):1575-1585. doi:10.7150/ijbs.41852. https://www.ijbs.com/v16p1575.htm
CSE
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. 2020. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci. 16(9):1575-1585.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.