Int J Biol Sci 2022; 18(11):4532-4544. doi:10.7150/ijbs.70784 This issue
1. Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
2. Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China.
3. Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.
4. Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
5. Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
*These authors are co-first authors and contributed equally to this work.
Disheveled-associated antagonist of β-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptosis, migration and differentiation. Given the importance of DACT in these cellular processes, many scientists are gradually interested in studying the role of DACT in tumorigenesis and cancer progression. This review article focuses on the latest research regarding the essential functions and potential DACT mechanisms in the occurrence and progression of tumors. Our study indicates that DACT may act as a tumor biomarker for cancer diagnosis and prognosis, as well as a promising therapeutic target in cancers.
Keywords: DACT family members, Cancer, Proliferation, Apoptosis, Invasion, Prognosis