Int J Biol Sci 2023; 19(3):967-980. doi:10.7150/ijbs.76407 This issue Cite

Research Paper

Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter

Xiaocong Lin1,2, Guodan Li1,2, Xiuwen Yan1,2, Weiyu Fu1,2, Jie Ruan1, Hang Ding1,2, Huajun Yu1,2, Xiaoyi Chen1,2, Liubo Lan1,2, Yong Dai3, Kai Pan4, Xinguang Liu1✉, Haitao Zhang1,2✉

1. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, Guangdong, China.
2. Peptide and Protein Research and Application Key Laboratory of Guangdong Medical University, Zhanjiang 524023, Guangdong, China.
3. Clinical Medical Research Center, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
4. Department of Gastrointestinal Surgery, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.

Citation:
Lin X, Li G, Yan X, Fu W, Ruan J, Ding H, Yu H, Chen X, Lan L, Dai Y, Pan K, Liu X, Zhang H. Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter. Int J Biol Sci 2023; 19(3):967-980. doi:10.7150/ijbs.76407. https://www.ijbs.com/v19p0967.htm
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Abstract

Graphic abstract

There is increasing evidence that long non-coding RNAs (lncRNAs) are involved in the pathogenesis and progression of gastric cancer (GC), however, the underlying mechanisms remain poorly understood. In this study, we identified lncRNA BC002811 as a critical regulator of GC development and progression. BC002811 was upregulated in GC tissues and cell lines, and that high expression of BC002811 was indicative of a reduction in overall survival of GC patients. Our research reveals that BC002811 promoted GC cell proliferation, migration, invasion, and inhibition of apoptosis in vitro, as well as accelerated tumor growth and metastasis in vivo. We also found that BC002811 upregulated MMP2 and MMP9 and promoted GC cell metastasis partially through downregulating PTEN expression. BC002811 may act as a molecular decoy for the transcription factor SOX2, thereby inhibiting the transcription of PTEN by blocking SOX2 binding to the PTEN promoter. Our study advances the understanding of the role of BC002811 in the pathogenesis of GC and provides new molecular targets for therapeutic intervention against GC metastasis.

Keywords: Long non-coding RNA, Gastric cancer, Tumor metastasis, PTEN


Citation styles

APA
Lin, X., Li, G., Yan, X., Fu, W., Ruan, J., Ding, H., Yu, H., Chen, X., Lan, L., Dai, Y., Pan, K., Liu, X., Zhang, H. (2023). Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter. International Journal of Biological Sciences, 19(3), 967-980. https://doi.org/10.7150/ijbs.76407.

ACS
Lin, X.; Li, G.; Yan, X.; Fu, W.; Ruan, J.; Ding, H.; Yu, H.; Chen, X.; Lan, L.; Dai, Y.; Pan, K.; Liu, X.; Zhang, H. Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter. Int. J. Biol. Sci. 2023, 19 (3), 967-980. DOI: 10.7150/ijbs.76407.

NLM
Lin X, Li G, Yan X, Fu W, Ruan J, Ding H, Yu H, Chen X, Lan L, Dai Y, Pan K, Liu X, Zhang H. Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter. Int J Biol Sci 2023; 19(3):967-980. doi:10.7150/ijbs.76407. https://www.ijbs.com/v19p0967.htm

CSE
Lin X, Li G, Yan X, Fu W, Ruan J, Ding H, Yu H, Chen X, Lan L, Dai Y, Pan K, Liu X, Zhang H. 2023. Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the PTEN Promoter. Int J Biol Sci. 19(3):967-980.

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