Int J Biol Sci 2013; 9(9):960-965. doi:10.7150/ijbs.6739 This issue Cite

Short Research Communication

Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth

Hyehyun Min, Ji-Yeon Lee, Myoung Hee Kim

Department of Anatomy, Embryology Laboratory, Brain Korea 21 project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.

Citation:
Min H, Lee JY, Kim MH. Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth. Int J Biol Sci 2013; 9(9):960-965. doi:10.7150/ijbs.6739. https://www.ijbs.com/v09p0960.htm
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Abstract

The Hox genes, which are organized into clusters on different chromosomes, are key regulators of embryonic anterior-posterior (A-P) body pattern formation and are expressed at specific times and in specific positions in developing vertebrate embryos. Previously, we have shown that histone methylation patterns are closely correlated with collinear Hox gene expression patterns along the A-P axis of E14.5 mouse embryos. Since histone modification is thought to play a crucial mechanistic role in the highly coordinated pattern of collinear Hox gene expression, we examined the maintenance of the spatial collinear expression pattern of Hoxc genes and the corresponding histone modifications during embryogenesis and in early postnatal mice. Hox expression patterns and histone modifications were analyzed by semi-quantitative RT-PCR and chromatin immunoprecipitation (ChIP)-PCR analyses, respectively. The spatiotemporal expression patterns of Hoxc genes in a cluster were maintained until the early postnatal stage (from E8.5 through P5). Examination of histone modifications in E14.5 and P5 tissues revealed that level of H3K27me3 is only a weak correlation with collinear Hoxc gene expression in the trunk regions although diminished in general, however the enrichment of H3K4me3 is strongly correlated with the gene expression in both stages. In summary, the initial spatiotemporal collinear expression pattern of Hoxc genes and epigenetic modifications are maintained after birth, likely contributing to the establishment of the gene expression code for position in the anatomic body axis throughout the entire life of the organism.

Keywords: Hoxc cluster genes, collinear expression: anterior-posterior body axis, mouse embryogenesis, histone modification.


Citation styles

APA
Min, H., Lee, J.Y., Kim, M.H. (2013). Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth. International Journal of Biological Sciences, 9(9), 960-965. https://doi.org/10.7150/ijbs.6739.

ACS
Min, H.; Lee, J.Y.; Kim, M.H. Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth. Int. J. Biol. Sci. 2013, 9 (9), 960-965. DOI: 10.7150/ijbs.6739.

NLM
Min H, Lee JY, Kim MH. Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth. Int J Biol Sci 2013; 9(9):960-965. doi:10.7150/ijbs.6739. https://www.ijbs.com/v09p0960.htm

CSE
Min H, Lee JY, Kim MH. 2013. Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth. Int J Biol Sci. 9(9):960-965.

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