Int J Biol Sci 2023; 19(6):1955-1967. doi:10.7150/ijbs.80401 This issue Cite

Review

Advances in the multi-omics landscape of follicular lymphoma

Tianyuan Xu, Zhong Zheng, Weili Zhao

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Citation:
Xu T, Zheng Z, Zhao W. Advances in the multi-omics landscape of follicular lymphoma. Int J Biol Sci 2023; 19(6):1955-1967. doi:10.7150/ijbs.80401. https://www.ijbs.com/v19p1955.htm
Other styles

File import instruction

Abstract

Graphic abstract

Follicular lymphoma (FL) is the most common indolent lymphoma originating from germinal center B cells. FL represents a clinically and biologically heterogeneous disease. Most patients have favorable outcomes, but a subset of patients experiences early progression or transformation and has a poor prognosis. Abnormalities in FL cells and tumor microenvironment have been revealed using multi-omics techniques, including genomic, epigenomic, transcriptomic and proteomic analysis. Recurrent somatic gene aberrations mainly involve epigenetic modifiers, transcription factors, oncogenic pathways and microenvironment modulators. Single-cell transcriptomic analysis show marked inter- and intra-patient FL subclone heterogeneity. In addition, a comprehensive profile of microenvironmental components is provided, unveiling the crosstalk between tumor and microenvironment that induce FL progression and facilitate immune escape. Together, these studies provide insights into the mechanisms and biomarkers of high-risk FL populations, as well as the potential targeted and immunotherapy options. Future research should focus on integrating multi-omics aberrations to optimize therapeutic strategies in FL.

Keywords: follicular lymphoma, genomics, transcriptomics, microenvironment, biomarkers, targeted therapy, immunotherapy


Citation styles

APA
Xu, T., Zheng, Z., Zhao, W. (2023). Advances in the multi-omics landscape of follicular lymphoma. International Journal of Biological Sciences, 19(6), 1955-1967. https://doi.org/10.7150/ijbs.80401.

ACS
Xu, T.; Zheng, Z.; Zhao, W. Advances in the multi-omics landscape of follicular lymphoma. Int. J. Biol. Sci. 2023, 19 (6), 1955-1967. DOI: 10.7150/ijbs.80401.

NLM
Xu T, Zheng Z, Zhao W. Advances in the multi-omics landscape of follicular lymphoma. Int J Biol Sci 2023; 19(6):1955-1967. doi:10.7150/ijbs.80401. https://www.ijbs.com/v19p1955.htm

CSE
Xu T, Zheng Z, Zhao W. 2023. Advances in the multi-omics landscape of follicular lymphoma. Int J Biol Sci. 19(6):1955-1967.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image