ISSN: 1449-2288International Journal of Biological Sciences
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Volume 21 (1); 2025
Research Papers
Oncogenic RARγ isoforms promote head and neck cancer proliferation through vinexin-β-mediated cell cycle acceleration and autocrine activation of EGFR signal
Yu-Chu Su, Shang-Yin Wu, Keng-Fu Hsu, Shih-Sheng Jiang, Ping-Chung Kuo, Ai-Li Shiau, Chao-Liang Wu, Yang-Kao Wang, Jenn-Ren Hsiao
Int. J. Biol. Sci. 2025; 21(1): 1-16. doi:10.7150/ijbs.100351
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Advanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment
Eun-Kyung Min, Choon-Mi Lee, Soo-Rim Kim, Jin Woo Lee, Chan Hum Park, Byung-Chul Oh, YunJae Jung, Hwa-Yong Lee
Int. J. Biol. Sci. 2025; 21(1): 17-39. doi:10.7150/ijbs.105702
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Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway
Zhiwei Zhou, Mohd Farhan, Xingan Xing, Wenshu Zhou, Ruohong Lin, Shan Zeng, Mengfang Li, Wenhua Zheng
Int. J. Biol. Sci. 2025; 21(1): 75-94. doi:10.7150/ijbs.97341
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The modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells
Ya Meng, Chunhao Deng, Xia Xiao, Shengnan Wei, Chengcheng Song, Jiaxian Wang, Chon Lok Lei, Weiwei Liu, Guokai Chen
Int. J. Biol. Sci. 2025; 21(1): 95-108. doi:10.7150/ijbs.95568
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Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Wenjie Dou, Yan Jiao, Juanli Dang, Qing Yang, Zhou Yu, Baoqiang Song
Int. J. Biol. Sci. 2025; 21(1): 109-127. doi:10.7150/ijbs.91661
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BRAF-activated ARSI suppressed EREG-mediated ferroptosis to promote BRAFV600E (mutant) papillary thyroid carcinoma progression and sorafenib resistance
Xing Chen, Xiang Chen, Wenjun Xie, Hua Ge, Hongyan He, Ailong Zhang, Junjie Zheng
Int. J. Biol. Sci. 2025; 21(1): 128-142. doi:10.7150/ijbs.99423
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TBK1 inhibitor amlexanox exerts anti-cancer effects against endometrial cancer by regulating AKT/NF-κB signaling
Jiha Shin, Jihoon Lim, Daewon Han, Solji Lee, Nak Song Sung, Jong-Seok Kim, Do Kyung Kim, Hoi Young Lee, Sung Ki Lee, Jongdae Shin, Jeong Sig Kim, Hwan-Woo Park
Int. J. Biol. Sci. 2025; 21(1): 143-159. doi:10.7150/ijbs.100212
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DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis
Zhun Wei, Di Zheng, Kezhou Xia, Xinghan Huang, Wenda Liu, Zicheng Wei, Weichun Guo
Int. J. Biol. Sci. 2025; 21(1): 160-174. doi:10.7150/ijbs.101137
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Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments
Can Li, Jirui Wen, Ling Wang, Jun Lei, Zhengdong Lin, Yuhao Zou, Juan Cheng, Xuehong Wan, Jifeng Liu, Jiang Wu
Int. J. Biol. Sci. 2025; 21(1): 175-188. doi:10.7150/ijbs.103122
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METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification
Senfeng Zhao, Jiahui Cao, Ruopeng Liang, Tingting Peng, Shitao Wu, Zhipu Liu, Yahui Wu, Liming Song, Chenguang Sun, Yin Liu, Junmou Gu, Libo Wang, Rongtao Zhu, Weijie Wang, Yuling Sun
Int. J. Biol. Sci. 2025; 21(1): 189-203. doi:10.7150/ijbs.97886
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Aberrant activation of adenine nucleotide translocase 3 promotes progression and chemoresistance in multiple myeloma dependent on PINK1 transport
Ke Hu, Yue Lai, Jinfeng Zhou, Chaolu Hu, Shushan Guo, Hui Zhang, Guanli Wang, Qikai Zhang, Xuejie Gao, Zhuning Wang, Yujie Liu, Qilin Feng, Hongfei Yi, Yu Peng, Yifei Zhang, Xiaosong Wu, Haiyan Cai, Jumei Shi
Int. J. Biol. Sci. 2025; 21(1): 233-250. doi:10.7150/ijbs.101850
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The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway
Maria. E. Bernis, Hannah Burkard, Anna-Sophie Bremer, Kora Grzelak, Margit Zweyer, Elke Maes, Efe Nacarkucuk, Hanna Kaibel, Charlotte Hakvoort, Andreas Müller, Hemmen Sabir
Int. J. Biol. Sci. 2025; 21(1): 251-270. doi:10.7150/ijbs.101087
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Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway
Annachiara Tesoriere, Rachele Ghirardo, Francesca Terrin, Francesco Sernesi, Giacomo Meneghetti, Luisa Dalla Valle, Alberto Dinarello, Francesco Argenton
Int. J. Biol. Sci. 2025; 21(1): 271-284. doi:10.7150/ijbs.96400
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Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway
Tao Li, Xiaoyu Song, Jiena Chen, Yuan Li, Jie Lin, Ping Li, Simiao Yu, Olanrewaju Ayodeji Durojaye, Fengrui Yang, Xing Liu, Jian Li, Shiyuan Cheng, Xuebiao Yao, Xia Ding
Int. J. Biol. Sci. 2025; 21(1): 285-305. doi:10.7150/ijbs.97109
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CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity
Fang Wang, Qian Wang, Yongfeng Wu, Zebo Huang, Xincao Zhong, Hunan Wang, Chen Yang, Yan Qin, Xiaowei Qi, Xiaosong Ge, Yong Mao
Int. J. Biol. Sci. 2025; 21(1): 306-327. doi:10.7150/ijbs.105324
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TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner
Xiaowen Yang, Xinzhuang Shen, Zongjun Liu, Yifei Li, Hangchu Liu, Yiting Zhan, Yipeng Liu, Chengjin Liang, Luping Zhao, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen
Int. J. Biol. Sci. 2025; 21(1): 328-345. doi:10.7150/ijbs.97920
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Helicobacter Pylori-induced BRD2 m6A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis
Sen Wang, Zhe Xuan, Zetian Chen, Penghui Xu, Lang Fang, Zheng Li, Yigang Zhang, Hongda Liu, Linjun Wang, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu
Int. J. Biol. Sci. 2025; 21(1): 346-362. doi:10.7150/ijbs.97464
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Quantitative Histopathology Analysis Based on Label-free Multiphoton Imaging for Breast Cancer Diagnosis and Neoadjuvant Immunotherapy Response Assessment
Ruiqi Zhong, Ying Zhang, Wenzhuo Qiu, Kaipeng Zhang, Qianqian Feng, Xiuxue Cao, Qixin Huang, Yijing Zhang, Yuanyuan Guo, Jia Guo, Lingyu Zhao, Xiuhong Wang, Shuhao Wang, Lifang Cui, Aimin Wang, Haili Qian, Fei Ma
Int. J. Biol. Sci. 2025; 21(1): 363-381. doi:10.7150/ijbs.102744
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Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness
Zihan Xu, Li Wang, Li Tu, Tao Liu, Yong Zhang, Yingying He, Guixiu Xiao, Ganlu Ouyang, Xuelei Ma, Feng Luo
Int. J. Biol. Sci. 2025; 21(1): 382-399. doi:10.7150/ijbs.99954
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Nuclear receptor 4A1 Regulates Mitochondrial Homeostasis in Cardiac Post-Ischemic Injury by Controlling Mitochondrial Fission 1 Protein-Mediated Fragmentation and Parkin-Dependent Mitophagy
Haoran Ye, Jialong Lin, Hui Zhang, Jing Wang, Yuan Fu, Zhaopei Zeng, Junmeng Zheng, Jun Tao, Junxiong Qiu
Int. J. Biol. Sci. 2025; 21(1): 400-414. doi:10.7150/ijbs.104680
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IGF1R Enhances Calcium Oxalate Monohydrate-Induced Epithelial-Mesenchymal Transition by Reprogramming Metabolism via the JAK2/STAT3 Signaling
Jiashan Pan, Yi Zhang, Rui Yao, Mo Yang, Xike Mao, Zhenyu Song, Yuexian Xu, Yang Chen, Bingbing Hou, Xiaoying Liu, Wei Wang, Zongyao Hao
Int. J. Biol. Sci. 2025; 21(1): 415-432. doi:10.7150/ijbs.104311
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Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury
Yunmin Shi, Tian He, Hong Liu, Xiaodong Li, Zhengxin Li, Qing Wen, Zhaohui Dai, Xuejing Sun, Qian Tan, Wenjing Yang, Youxiang Jiang, Yuanyuan Liu, Hong Yuan, Fang Lei, Yang Yi, Jingjing Cai
Int. J. Biol. Sci. 2025; 21(1): 433-453. doi:10.7150/ijbs.97106
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Reviews
Relationship between exosomes and cancer: formation, diagnosis, and treatment
Chen Huang, Jiajin Li, Zichuan Xie, Xiangjun Hu, Yan Huang
Int. J. Biol. Sci. 2025; 21(1): 40-62. doi:10.7150/ijbs.95763
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Targeting protein modification: a new direction for immunotherapy of pancreatic cancer
Xinyu Ge, Ke Zhang, Jie Zhu, Yuan Chen, Zhengwang Wang, Peng Wang, Peng Xu, Jie Yao
Int. J. Biol. Sci. 2025; 21(1): 63-74. doi:10.7150/ijbs.101861
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The role of RGC degeneration in the pathogenesis of glaucoma
Zhibo Si, Yuhang Fan, Mingxuan Wang, Jing Zhao, Yunmei Zhang, Dongmei Liu, Yajuan Zheng
Int. J. Biol. Sci. 2025; 21(1): 211-232. doi:10.7150/ijbs.103222
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