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Volume 21 (1); 2025

Research Papers

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Oncogenic RARγ isoforms promote head and neck cancer proliferation through vinexin-β-mediated cell cycle acceleration and autocrine activation of EGFR signal Yu-Chu Su, Shang-Yin Wu, Keng-Fu Hsu, Shih-Sheng Jiang, Ping-Chung Kuo, Ai-Li Shiau, Chao-Liang Wu, Yang-Kao Wang, Jenn-Ren Hsiao Int. J. Biol. Sci. 2025; 21(1): 1-16. doi:10.7150/ijbs.100351 Full text PDF PubMed PMC

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Advanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment Eun-Kyung Min, Choon-Mi Lee, Soo-Rim Kim, Jin Woo Lee, Chan Hum Park, Byung-Chul Oh, YunJae Jung, Hwa-Yong Lee Int. J. Biol. Sci. 2025; 21(1): 17-39. doi:10.7150/ijbs.105702 Full text PDF PubMed PMC

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Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway Zhiwei Zhou, Mohd Farhan, Xingan Xing, Wenshu Zhou, Ruohong Lin, Shan Zeng, Mengfang Li, Wenhua Zheng Int. J. Biol. Sci. 2025; 21(1): 75-94. doi:10.7150/ijbs.97341 Full text PDF PubMed PMC

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The modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells Ya Meng, Chunhao Deng, Xia Xiao, Shengnan Wei, Chengcheng Song, Jiaxian Wang, Chon Lok Lei, Weiwei Liu, Guokai Chen Int. J. Biol. Sci. 2025; 21(1): 95-108. doi:10.7150/ijbs.95568 Full text PDF PubMed PMC

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Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Wenjie Dou, Yan Jiao, Juanli Dang, Qing Yang, Zhou Yu, Baoqiang Song Int. J. Biol. Sci. 2025; 21(1): 109-127. doi:10.7150/ijbs.91661 Full text PDF PubMed PMC

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BRAF-activated ARSI suppressed EREG-mediated ferroptosis to promote BRAFV600E (mutant) papillary thyroid carcinoma progression and sorafenib resistance Xing Chen, Xiang Chen, Wenjun Xie, Hua Ge, Hongyan He, Ailong Zhang, Junjie Zheng Int. J. Biol. Sci. 2025; 21(1): 128-142. doi:10.7150/ijbs.99423 Full text PDF PubMed PMC

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TBK1 inhibitor amlexanox exerts anti-cancer effects against endometrial cancer by regulating AKT/NF-κB signaling Jiha Shin, Jihoon Lim, Daewon Han, Solji Lee, Nak Song Sung, Jong-Seok Kim, Do Kyung Kim, Hoi Young Lee, Sung Ki Lee, Jongdae Shin, Jeong Sig Kim, Hwan-Woo Park Int. J. Biol. Sci. 2025; 21(1): 143-159. doi:10.7150/ijbs.100212 Full text PDF PubMed PMC

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DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis Zhun Wei, Di Zheng, Kezhou Xia, Xinghan Huang, Wenda Liu, Zicheng Wei, Weichun Guo Int. J. Biol. Sci. 2025; 21(1): 160-174. doi:10.7150/ijbs.101137 Full text PDF PubMed PMC

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Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments Can Li, Jirui Wen, Ling Wang, Jun Lei, Zhengdong Lin, Yuhao Zou, Juan Cheng, Xuehong Wan, Jifeng Liu, Jiang Wu Int. J. Biol. Sci. 2025; 21(1): 175-188. doi:10.7150/ijbs.103122 Full text PDF PubMed PMC

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METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification Senfeng Zhao, Jiahui Cao, Ruopeng Liang, Tingting Peng, Shitao Wu, Zhipu Liu, Yahui Wu, Liming Song, Chenguang Sun, Yin Liu, Junmou Gu, Libo Wang, Rongtao Zhu, Weijie Wang, Yuling Sun Int. J. Biol. Sci. 2025; 21(1): 189-203. doi:10.7150/ijbs.97886 Full text PDF PubMed PMC

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Aberrant activation of adenine nucleotide translocase 3 promotes progression and chemoresistance in multiple myeloma dependent on PINK1 transport Ke Hu, Yue Lai, Jinfeng Zhou, Chaolu Hu, Shushan Guo, Hui Zhang, Guanli Wang, Qikai Zhang, Xuejie Gao, Zhuning Wang, Yujie Liu, Qilin Feng, Hongfei Yi, Yu Peng, Yifei Zhang, Xiaosong Wu, Haiyan Cai, Jumei Shi Int. J. Biol. Sci. 2025; 21(1): 233-250. doi:10.7150/ijbs.101850 Full text PDF PubMed PMC

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The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway Maria. E. Bernis, Hannah Burkard, Anna-Sophie Bremer, Kora Grzelak, Margit Zweyer, Elke Maes, Efe Nacarkucuk, Hanna Kaibel, Charlotte Hakvoort, Andreas Müller, Hemmen Sabir Int. J. Biol. Sci. 2025; 21(1): 251-270. doi:10.7150/ijbs.101087 Full text PDF PubMed PMC

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Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway Annachiara Tesoriere, Rachele Ghirardo, Francesca Terrin, Francesco Sernesi, Giacomo Meneghetti, Luisa Dalla Valle, Alberto Dinarello, Francesco Argenton Int. J. Biol. Sci. 2025; 21(1): 271-284. doi:10.7150/ijbs.96400 Full text PDF PubMed PMC

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Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway Tao Li, Xiaoyu Song, Jiena Chen, Yuan Li, Jie Lin, Ping Li, Simiao Yu, Olanrewaju Ayodeji Durojaye, Fengrui Yang, Xing Liu, Jian Li, Shiyuan Cheng, Xuebiao Yao, Xia Ding Int. J. Biol. Sci. 2025; 21(1): 285-305. doi:10.7150/ijbs.97109 Full text PDF PubMed PMC

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CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity Fang Wang, Qian Wang, Yongfeng Wu, Zebo Huang, Xincao Zhong, Hunan Wang, Chen Yang, Yan Qin, Xiaowei Qi, Xiaosong Ge, Yong Mao Int. J. Biol. Sci. 2025; 21(1): 306-327. doi:10.7150/ijbs.105324 Full text PDF PubMed PMC

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TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner Xiaowen Yang, Xinzhuang Shen, Zongjun Liu, Yifei Li, Hangchu Liu, Yiting Zhan, Yipeng Liu, Chengjin Liang, Luping Zhao, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen Int. J. Biol. Sci. 2025; 21(1): 328-345. doi:10.7150/ijbs.97920 Full text PDF PubMed PMC

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Helicobacter Pylori-induced BRD2 m6A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis Sen Wang, Zhe Xuan, Zetian Chen, Penghui Xu, Lang Fang, Zheng Li, Yigang Zhang, Hongda Liu, Linjun Wang, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu Int. J. Biol. Sci. 2025; 21(1): 346-362. doi:10.7150/ijbs.97464 Full text PDF PubMed PMC

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Quantitative Histopathology Analysis Based on Label-free Multiphoton Imaging for Breast Cancer Diagnosis and Neoadjuvant Immunotherapy Response Assessment Ruiqi Zhong, Ying Zhang, Wenzhuo Qiu, Kaipeng Zhang, Qianqian Feng, Xiuxue Cao, Qixin Huang, Yijing Zhang, Yuanyuan Guo, Jia Guo, Lingyu Zhao, Xiuhong Wang, Shuhao Wang, Lifang Cui, Aimin Wang, Haili Qian, Fei Ma Int. J. Biol. Sci. 2025; 21(1): 363-381. doi:10.7150/ijbs.102744 Full text PDF PubMed PMC

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Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness Zihan Xu, Li Wang, Li Tu, Tao Liu, Yong Zhang, Yingying He, Guixiu Xiao, Ganlu Ouyang, Xuelei Ma, Feng Luo Int. J. Biol. Sci. 2025; 21(1): 382-399. doi:10.7150/ijbs.99954 Full text PDF PubMed PMC

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Nuclear receptor 4A1 Regulates Mitochondrial Homeostasis in Cardiac Post-Ischemic Injury by Controlling Mitochondrial Fission 1 Protein-Mediated Fragmentation and Parkin-Dependent Mitophagy Haoran Ye, Jialong Lin, Hui Zhang, Jing Wang, Yuan Fu, Zhaopei Zeng, Junmeng Zheng, Jun Tao, Junxiong Qiu Int. J. Biol. Sci. 2025; 21(1): 400-414. doi:10.7150/ijbs.104680 Full text PDF PubMed PMC

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IGF1R Enhances Calcium Oxalate Monohydrate-Induced Epithelial-Mesenchymal Transition by Reprogramming Metabolism via the JAK2/STAT3 Signaling Jiashan Pan, Yi Zhang, Rui Yao, Mo Yang, Xike Mao, Zhenyu Song, Yuexian Xu, Yang Chen, Bingbing Hou, Xiaoying Liu, Wei Wang, Zongyao Hao Int. J. Biol. Sci. 2025; 21(1): 415-432. doi:10.7150/ijbs.104311 Full text PDF PubMed PMC

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Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury Yunmin Shi, Tian He, Hong Liu, Xiaodong Li, Zhengxin Li, Qing Wen, Zhaohui Dai, Xuejing Sun, Qian Tan, Wenjing Yang, Youxiang Jiang, Yuanyuan Liu, Hong Yuan, Fang Lei, Yi Yang, Jingjing Cai Int. J. Biol. Sci. 2025; 21(1): 433-453. doi:10.7150/ijbs.97106 Full text PDF PubMed PMC

Reviews

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Relationship between exosomes and cancer: formation, diagnosis, and treatment Chen Huang, Jiajin Li, Zichuan Xie, Xiangjun Hu, Yan Huang Int. J. Biol. Sci. 2025; 21(1): 40-62. doi:10.7150/ijbs.95763 Full text PDF PubMed PMC

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Targeting protein modification: a new direction for immunotherapy of pancreatic cancer Xinyu Ge, Ke Zhang, Jie Zhu, Yuan Chen, Zhengwang Wang, Peng Wang, Peng Xu, Jie Yao Int. J. Biol. Sci. 2025; 21(1): 63-74. doi:10.7150/ijbs.101861 Full text PDF PubMed PMC

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The role of RGC degeneration in the pathogenesis of glaucoma Zhibo Si, Yuhang Fan, Mingxuan Wang, Jing Zhao, Yunmei Zhang, Dongmei Liu, Yajuan Zheng Int. J. Biol. Sci. 2025; 21(1): 211-232. doi:10.7150/ijbs.103222 Full text PDF PubMed PMC

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