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Volume 20 (15); 2024

Research Papers

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Dual-Multivalent Aptamer-Based Drug Delivery Platform for Targeted SRC Silencing to Enhance Doxorubicin Sensitivity in Endometrial Cancer
Haojia Li, Shuangshuang Cheng, Qi Zhang, Ting Zhou, Tangansu Zhang, Shuangge Liu, Yingying Peng, Jia Yu, Jingwen Xu, Qi Wang, Jun Zhang, Yuwei Yao, Hongbo Wang
Int. J. Biol. Sci. 2024; 20(15): 5812-5830. doi:10.7150/ijbs.101059
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Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK
Yunhuan Gao, Jianmei Yue, Fushuang Ha, Ya Wang, Rong Wang, Xiaorong Yang, Junqi Zhang, Xinqi Liu, Yuan Zhang, Tao Han, Rongcun Yang
Int. J. Biol. Sci. 2024; 20(15): 5831-5849. doi:10.7150/ijbs.97059
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NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0/G1 phase arrest and upregulation of CDKN2AIP expression
Xinge Zhao, Xuejie Min, Zhenyu Wang, Xiaoxia Chen, Chao Ge, Fangyu Zhao, Hua Tian, Taoyang Chen, Jinjun Li
Int. J. Biol. Sci. 2024; 20(15): 5850-5867. doi:10.7150/ijbs.95174
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Development of Advanced Oral-on-a-Chip: Replicating the Intricate Human Oral Microenvironment
Soo-Rim Kim, Eun-Kyung Min, Choon-Mi Lee, Jin Woo Lee, Chan Hum Park, YunJae Jung, Byung-Chul Oh, Hwa-Yong Lee
Int. J. Biol. Sci. 2024; 20(15): 5888-5909. doi:10.7150/ijbs.104351
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SCGN recruits macrophages by regulating chemokine secretion in clear cell renal cell carcinoma
Tuanjie Guo, Xinchao Zhang, Xuan Wang, Heting Tang, Yang Liu, Siteng Chen, Zhengchuan Niu, Chaofu Wang, Xu Wang, Xiang Wang
Int. J. Biol. Sci. 2024; 20(15): 5925-5938. doi:10.7150/ijbs.103252
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FOXO1-mediated nuclear sequestration of STAT3 and AKT1 triggers FOXO3-dependent autophagic death in hypoxic granulosa cells
Chengyu Li, Gang Wu, Caibo Ning, Zhaojun Liu, Jingli Tao, Xiumei Lu, Ming Shen, Honglin Liu
Int. J. Biol. Sci. 2024; 20(15): 5939-5958. doi:10.7150/ijbs.101309
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Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8+ T Cells during JEV Infection
Weijia Zhang, Qing Yu, Xiaochen Gao, Haowei Chen, Jie Su, Yanru Chen, Yanling Li, Nan Zhang, Zhenfang Fu, Min Cui
Int. J. Biol. Sci. 2024; 20(15): 5959-5978. doi:10.7150/ijbs.102372
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Complement C1q is a key player in tumor-associated macrophage-mediated CD8+ T cell and NK cell dysfunction in malignant pleural effusion
Feng-Shuang Yi, Xin Qiao, Shu-Feng Dong, Qing-Yu Chen, Rui-Qi Wei, Ming-Ming Shao, Huan-Zhong Shi
Int. J. Biol. Sci. 2024; 20(15): 5979-5998. doi:10.7150/ijbs.100607
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Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline
Wenxin Qi, Yiwei Ying, Peiru Wu, Naijun Dong, Wenjun Fu, Qian Liu, Natalie Ward, Xin Dong, Robert Chunhua Zhao, Jiao Wang
Int. J. Biol. Sci. 2024; 20(15): 5999-6017. doi:10.7150/ijbs.103225
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PFKP silencing suppresses tumor growth via the AXL-MET axis
Huijie Zhao, Yuze Sun, Huijing Feng, Jing Cai, Yue Liu, Yu Li, Sijie Chen, Zhiqing Zhou, Yuhui Du, Xiaofei Zeng, Huan Ren, Wenmei Su, Qi Mei, Guoan Chen
Int. J. Biol. Sci. 2024; 20(15): 6056-6072. doi:10.7150/ijbs.100525
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Annexin-V binds subpopulation of immune cells altering its interpretation as an in vivo biomarker for apoptosis in the retina
Kiyoharu Joshua Miyagishima, Francisco Manuel Nadal-Nicolás, Wenxin Ma, Wei Li
Int. J. Biol. Sci. 2024; 20(15): 6073-6089. doi:10.7150/ijbs.102551
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Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway
Sheng-Chieh Tsai, Po-Chih Chang, Yu Tong Lin, Po-Tsang Huang, Jeff Yi-Fu Chen, Chang‑Shen Lin, Bin-Nan Wu, Hui-Min Chang, Wan-Ju Wu, Chi-I Chang, Chien-Hsing Lee
Int. J. Biol. Sci. 2024; 20(15): 6090-6113. doi:10.7150/ijbs.99859
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Smad4 Deficiency in S100A4+ Macrophages Enhances Colitis-associated Tumorigenesis by Promoting Macrophage Lipid Metabolism Augmented M2 Polarization
Ting Liu, Xinyuan Zhang, Xuanxuan Yan, Leirong Cheng, Xinlong Yan, Fanxin Zeng, Xue Li, Zhinan Chen, Jianchun Gu, Jinhua Zhang
Int. J. Biol. Sci. 2024; 20(15): 6114-6129. doi:10.7150/ijbs.98529
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BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair
Mengna Li, Jianxia Wei, Changning Xue, Shipeng Chen, Xiangting Zhou, Lemei Zheng, Yumei Duan, Hongyu Deng, Songqing Fan, Wei Xiong, Faqing Tang, Ming Zhou
Int. J. Biol. Sci. 2024; 20(15): 6130-6145. doi:10.7150/ijbs.100833
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IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway
Shiwei Liu, Junhong Li, Junyu Zhang, Fangning Wan, Zongyuan Hong, Zhe Hong, Bo Dai
Int. J. Biol. Sci. 2024; 20(15): 6146-6161. doi:10.7150/ijbs.102666
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Probiotic-facilitated cytokine-induced killer cells suppress peritoneal carcinomatosis and liver metastasis in colorectal cancer cells
Hong-Hwa Chen, Chi-Wen Luo, Yi-Ling Chen, John Y. Chiang, Chi-Ruei Huang, Yi-Ting Wang, Chih-Hung Chen, Jun Guo, Hon-Kan Yip
Int. J. Biol. Sci. 2024; 20(15): 6162-6180. doi:10.7150/ijbs.101051
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MicroRNA-495 Modulates Neuronal Layer Fate Determination by Targeting Tcf4
Yunli Pang, Xiangbin Ruan, Wei Liu, Lin Hou, Bin Yin, Pengcheng Shu, Xiaozhong Peng
Int. J. Biol. Sci. 2024; 20(15): 6207-6221. doi:10.7150/ijbs.94739
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High-Throughput Screening of an FDA-Approved Compound Library Reveals a Novel GAS6 Receptor Agonist for Therapeutic Intervention in Septic Myocardial and microvascular Injury via Modulation of Danger-Associated Molecular Patterns
Haowen Zhuang, Chun Li, Lingjun Wang, Bei Zhou, Zhijiang Guo, Yusheng Huang, Bo Deng, Yulin Ouyang, Junxiong Qiu, Xing Chang, Wei Wang, Junyan Wang
Int. J. Biol. Sci. 2024; 20(15): 6222-6240. doi:10.7150/ijbs.104427
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Extracellular Vesicles from Human Induced Pluripotent Stem Cells Exhibit a Unique MicroRNA and CircRNA Signature
Mario Barilani, Valeria Peli, Paolo Manzini, Clelia Pistoni, Francesco Rusconi, Eva Maria Pinatel, Francesca Pischiutta, Dorian Tace, Maria Chiara Iachini, Noemi Elia, Francesca Tribuzio, Federica Banfi, Alessandro Sessa, Alessandro Cherubini, Vincenza Dolo, Valentina Bollati, Luisa Fiandra, Elena Longhi, Elisa R Zanier, Lorenza Lazzari
Int. J. Biol. Sci. 2024; 20(15): 6255-6278. doi:10.7150/ijbs.100113
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The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis
Yang-Hsiang Lin, Hsiang‑Cheng Chi, Meng-Han Wu, Chia-Jung Liao, Cheng-Yi Chen, Po-Shuan Huang, Wei-Chieh Huang, Yi-Wen Wang, Tzu-Kang Lin, Ming-Wei Lai, Chau-Ting Yeh, Kwang-Huei Lin
Int. J. Biol. Sci. 2024; 20(15): 6281-6296. doi:10.7150/ijbs.99683
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Reviews

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The cGAS-STING/PERK-eIF2α: Individual or Potentially Collaborative Signaling Transduction in Cardiovascular Diseases
Xueqi Wan, Huan Zhang, Jinfan Tian, Libo Liu, Ziyu An, Xin Zhao, Lijun Zhang, Xueyao Yang, Changjiang Ge, Xiantao Song
Int. J. Biol. Sci. 2024; 20(15): 5868-5887. doi:10.7150/ijbs.101247
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Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4
Haijun Guo, Shaohua Wang, Hui Zhang, Jie Li, Chao Wang, Zhikun Liu, Jun Chen, Kai Wang, Xuyong Wei, Qiang Wei, Xiao Xu
Int. J. Biol. Sci. 2024; 20(15): 5910-5924. doi:10.7150/ijbs.102460
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Fatty Acid Metabolism Disruptions: A Subtle yet Critical Factor in Adverse Pregnancy Outcomes
Xiao-Yan Cao, Meng-Ying Li, Chang-Xiang Shao, Jia-Lu Shi, Tao Zhang, Feng Xie, Ting Peng, Ming-Qing Li
Int. J. Biol. Sci. 2024; 20(15): 6018-6037. doi:10.7150/ijbs.103404
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Multi-Omics Approaches to Discover Biomarkers of Thyroid Eye Disease: A Systematic Review
Haiyang Zhang, Yuyu Zhou, Baiguang Yu, Yuyang Deng, Yang Wang, Sijie Fang, Xuefei Song, Xianqun Fan, Huifang Zhou
Int. J. Biol. Sci. 2024; 20(15): 6038-6055. doi:10.7150/ijbs.103977
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The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications
Chan Shan, Yuan Wang, Yin Wang
Int. J. Biol. Sci. 2024; 20(15): 6181-6206. doi:10.7150/ijbs.103187
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The Quiet Giant: Identification, Effectors, Molecular Mechanism, Physiological and Pathological Function in mRNA 5-methylcytosine Modification
Ruyue Wang, Lifeng Ding, Yudong Lin, Wenqin Luo, Zhehao Xu, Weilin Li, Yi Lu, Ziwei Zhu, Zeyi Lu, Fan Li, Xudong Mao, Liqun Xia, Gonghui Li
Int. J. Biol. Sci. 2024; 20(15): 6241-6254. doi:10.7150/ijbs.101337
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Erratum

Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway: Erratum
Yadong Liu, Huiyan Lv, Xingyi Li, Jiannan Liu, Song Chen, Yaodong Chen, Yinshan Jin, Ruihua An, Shiliang Yu, Zhigang Wang
Int. J. Biol. Sci. 2024; 20(15): 6279-6280. doi:10.7150/ijbs.87837
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