Volume 20, Issue 15

open access Global reach, higher impact

Volume 20 (15); 2024

Research Papers

Dual-Multivalent Aptamer-Based Drug Delivery Platform for Targeted SRC Silencing to Enhance Doxorubicin Sensitivity in Endometrial Cancer
Haojia Li, Shuangshuang Cheng, Qi Zhang, Ting Zhou, Tangansu Zhang, Shuangge Liu, Yingying Peng, Jia Yu, Jingwen Xu, Qi Wang, Jun Zhang, Yuwei Yao, Hongbo Wang
Int. J. Biol. Sci. 2024; 20(15): 5812-5830. doi:10.7150/ijbs.101059
Full text PDF

Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK
Yunhuan Gao, Jianmei Yue, Fushuang Ha, Ya Wang, Rong Wang, Xiaorong Yang, Junqi Zhang, Xinqi Liu, Yuan Zhang, Tao Han, Rongcun Yang
Int. J. Biol. Sci. 2024; 20(15): 5831-5849. doi:10.7150/ijbs.97059
Full text PDF

NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0/G1 phase arrest and upregulation of CDKN2AIP expression
Xinge Zhao, Xuejie Min, Zhenyu Wang, Xiaoxia Chen, Chao Ge, Fangyu Zhao, Hua Tian, Taoyang Chen, Jinjun Li
Int. J. Biol. Sci. 2024; 20(15): 5850-5867. doi:10.7150/ijbs.95174
Full text PDF

Development of Advanced Oral-on-a-Chip: Replicating the Intricate Human Oral Microenvironment
Soo-Rim Kim, Eun-Kyung Min, Choon-Mi Lee, Jin Woo Lee, Chan Hum Park, YunJae Jung, Byung-Chul Oh, Hwa-Yong Lee
Int. J. Biol. Sci. 2024; 20(15): 5888-5909. doi:10.7150/ijbs.104351
Full text PDF

SCGN recruits macrophages by regulating chemokine secretion in clear cell renal cell carcinoma
Tuanjie Guo, Xinchao Zhang, Xuan Wang, Heting Tang, Yang Liu, Siteng Chen, Zhengchuan Niu, Chaofu Wang, Xu Wang, Xiang Wang
Int. J. Biol. Sci. 2024; 20(15): 5925-5938. doi:10.7150/ijbs.103252
Full text PDF

FOXO1-mediated nuclear sequestration of STAT3 and AKT1 triggers FOXO3-dependent autophagic death in hypoxic granulosa cells
Chengyu Li, Gang Wu, Caibo Ning, Zhaojun Liu, Jingli Tao, Xiumei Lu, Ming Shen, Honglin Liu
Int. J. Biol. Sci. 2024; 20(15): 5939-5958. doi:10.7150/ijbs.101309
Full text PDF

Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8⁺ T Cells during JEV Infection
Weijia Zhang, Qing Yu, Xiaochen Gao, Haowei Chen, Jie Su, Yanru Chen, Yanling Li, Nan Zhang, Zhenfang Fu, Min Cui
Int. J. Biol. Sci. 2024; 20(15): 5959-5978. doi:10.7150/ijbs.102372
Full text PDF

Complement C1q is a key player in tumor-associated macrophage-mediated CD8⁺ T cell and NK cell dysfunction in malignant pleural effusion
Feng-Shuang Yi, Xin Qiao, Shu-Feng Dong, Qing-Yu Chen, Rui-Qi Wei, Ming-Ming Shao, Huan-Zhong Shi
Int. J. Biol. Sci. 2024; 20(15): 5979-5998. doi:10.7150/ijbs.100607
Full text PDF

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline
Wenxin Qi, Yiwei Ying, Peiru Wu, Naijun Dong, Wenjun Fu, Qian Liu, Natalie Ward, Xin Dong, Robert Chunhua Zhao, Jiao Wang
Int. J. Biol. Sci. 2024; 20(15): 5999-6017. doi:10.7150/ijbs.103225
Full text PDF

PFKP silencing suppresses tumor growth via the AXL-MET axis
Huijie Zhao, Yuze Sun, Huijing Feng, Jing Cai, Yue Liu, Yu Li, Sijie Chen, Zhiqing Zhou, Yuhui Du, Xiaofei Zeng, Huan Ren, Wenmei Su, Qi Mei, Guoan Chen
Int. J. Biol. Sci. 2024; 20(15): 6056-6072. doi:10.7150/ijbs.100525
Full text PDF

Annexin-V binds subpopulation of immune cells altering its interpretation as an in vivo biomarker for apoptosis in the retina
Kiyoharu Joshua Miyagishima, Francisco Manuel Nadal-Nicolás, Wenxin Ma, Wei Li
Int. J. Biol. Sci. 2024; 20(15): 6073-6089. doi:10.7150/ijbs.102551
Full text PDF

Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway
Sheng-Chieh Tsai, Po-Chih Chang, Yu Tong Lin, Po-Tsang Huang, Jeff Yi-Fu Chen, Chang‑Shen Lin, Bin-Nan Wu, Hui-Min Chang, Wan-Ju Wu, Chi-I Chang, Chien-Hsing Lee
Int. J. Biol. Sci. 2024; 20(15): 6090-6113. doi:10.7150/ijbs.99859
Full text PDF

Smad4 Deficiency in S100A4⁺ Macrophages Enhances Colitis-associated Tumorigenesis by Promoting Macrophage Lipid Metabolism Augmented M2 Polarization
Ting Liu, Xinyuan Zhang, Xuanxuan Yan, Leirong Cheng, Xinlong Yan, Fanxin Zeng, Xue Li, Zhinan Chen, Jianchun Gu, Jinhua Zhang
Int. J. Biol. Sci. 2024; 20(15): 6114-6129. doi:10.7150/ijbs.98529
Full text PDF

BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair
Mengna Li, Jianxia Wei, Changning Xue, Shipeng Chen, Xiangting Zhou, Lemei Zheng, Yumei Duan, Hongyu Deng, Songqing Fan, Wei Xiong, Faqing Tang, Ming Zhou
Int. J. Biol. Sci. 2024; 20(15): 6130-6145. doi:10.7150/ijbs.100833
Full text PDF

IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway
Shiwei Liu, Junhong Li, Junyu Zhang, Fangning Wan, Zongyuan Hong, Zhe Hong, Bo Dai
Int. J. Biol. Sci. 2024; 20(15): 6146-6161. doi:10.7150/ijbs.102666
Full text PDF

Probiotic-facilitated cytokine-induced killer cells suppress peritoneal carcinomatosis and liver metastasis in colorectal cancer cells
Hong-Hwa Chen, Chi-Wen Luo, Yi-Ling Chen, John Y. Chiang, Chi-Ruei Huang, Yi-Ting Wang, Chih-Hung Chen, Jun Guo, Hon-Kan Yip
Int. J. Biol. Sci. 2024; 20(15): 6162-6180. doi:10.7150/ijbs.101051
Full text PDF

MicroRNA-495 Modulates Neuronal Layer Fate Determination by Targeting Tcf4
Yunli Pang, Xiangbin Ruan, Wei Liu, Lin Hou, Bin Yin, Pengcheng Shu, Xiaozhong Peng
Int. J. Biol. Sci. 2024; 20(15): 6207-6221. doi:10.7150/ijbs.94739
Full text PDF

High-Throughput Screening of an FDA-Approved Compound Library Reveals a Novel GAS6 Receptor Agonist for Therapeutic Intervention in Septic Myocardial and microvascular Injury via Modulation of Danger-Associated Molecular Patterns
Haowen Zhuang, Chun Li, Lingjun Wang, Bei Zhou, Zhijiang Guo, Yusheng Huang, Bo Deng, Yulin Ouyang, Junxiong Qiu, Xing Chang, Wei Wang, Junyan Wang
Int. J. Biol. Sci. 2024; 20(15): 6222-6240. doi:10.7150/ijbs.104427
Full text PDF

Reviews

The cGAS-STING/PERK-eIF2α: Individual or Potentially Collaborative Signaling Transduction in Cardiovascular Diseases
Xueqi Wan, Huan Zhang, Jinfan Tian, Libo Liu, Ziyu An, Xin Zhao, Lijun Zhang, Xueyao Yang, Changjiang Ge, Xiantao Song
Int. J. Biol. Sci. 2024; 20(15): 5868-5887. doi:10.7150/ijbs.101247
Full text PDF

Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4
Haijun Guo, Shaohua Wang, Hui Zhang, Jie Li, Chao Wang, Zhikun Liu, Jun Chen, Kai Wang, Xuyong Wei, Qiang Wei, Xiao Xu
Int. J. Biol. Sci. 2024; 20(15): 5910-5924. doi:10.7150/ijbs.102460
Full text PDF

Fatty Acid Metabolism Disruptions: A Subtle yet Critical Factor in Adverse Pregnancy Outcomes
Xiao-Yan Cao, Meng-Ying Li, Chang-Xiang Shao, Jia-Lu Shi, Tao Zhang, Feng Xie, Ting Peng, Ming-Qing Li
Int. J. Biol. Sci. 2024; 20(15): 6018-6037. doi:10.7150/ijbs.103404
Full text PDF

Multi-Omics Approaches to Discover Biomarkers of Thyroid Eye Disease: A Systematic Review
Haiyang Zhang, Yuyu Zhou, Baiguang Yu, Yuyang Deng, Yang Wang, Sijie Fang, Xuefei Song, Xianqun Fan, Huifang Zhou
Int. J. Biol. Sci. 2024; 20(15): 6038-6055. doi:10.7150/ijbs.103977
Full text PDF

The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications
Chan Shan, Yuan Wang, Yin Wang
Int. J. Biol. Sci. 2024; 20(15): 6181-6206. doi:10.7150/ijbs.103187
Full text PDF