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Volume 22 (1); 2026

Research Papers

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LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer
Dan Liu, Minxia Liu, Dongjin Lv, Yuxiang Li, Hongjuan Guo, Bingxiao Lu, Hao Leng, Ruyu Yan, Hongtao Yu, Tomas Blom, Kecheng Zhou
Int. J. Biol. Sci. 2026; 22(1): 1-24. doi:10.7150/ijbs.115365
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Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys
Xichen Song, Caijuan Li, Yang Yang, Chunhui Huang, Min Chen, Song Lin, Zhonghai Huang, Wei Wang, Kai Liao, Huiyi Wei, Lu Wang, Hao Xu, Yizhi Chen, Yingqi Lin, Jiawei Li, Zhen Dai, Wenguang Xie, Xiao Zheng, Jianhao Wu, Jiale Gao, Jiaxi Wu, Zhuchi Tu, Libing Zhou, Lu Huang, Chaoran Ren, Kwok-Fai So, Peng Yin, Huiming Yang, Shihua Li, Liangxue Lai, Xiao-Jiang Li, Sen Yan
Int. J. Biol. Sci. 2026; 22(1): 25-42. doi:10.7150/ijbs.122557
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Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis
Huawei Chen, Xueyan Dai, Zhiwei Xiong, Huabin Cao, Chenghong Xing, Haotang Li, Xiaona Gao, Mingwen Hu, Fan Yang
Int. J. Biol. Sci. 2026; 22(1): 43-59. doi:10.7150/ijbs.123482
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The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects
Zhenyu Chen, Yi Xu, Cheng Qu, Gang Luo, Zhuochang Cai, Hang Liu, Ziyang Sun, Chao Zhou, Juehong Li, Cunyi Fan
Int. J. Biol. Sci. 2026; 22(1): 60-85. doi:10.7150/ijbs.122706
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A SENP7-SIRT1-IL-10 Axis Driven by DeSUMOylation Promotes Breg Differentiation and Immune Evasion in Colorectal Cancer
Yuhan Liao, Xinghua Zhuo, Yuan Huang, Huimeng Xu, Zhe Hao, Lanhui Huang, Haoxuan Zheng, Jun Zhou
Int. J. Biol. Sci. 2026; 22(1): 111-125. doi:10.7150/ijbs.118896
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Hepatic Stellate Cell-derived IL-11 Exacerbates Liver Fibrosis via Interplay between HSCs and Macrophages
Yu Zhang, Fangfang He, Mozi Lei, Wenhui Fan, Xingyu Liu, Ying Tao, Weinan Wang, Bingshun Wang, Likun Gong, Jing Chen
Int. J. Biol. Sci. 2026; 22(1): 126-141. doi:10.7150/ijbs.119659
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H3K27 Acetylation-driven IGF2BP2 Mutates during the Aging of MSCs, thereby Influencing Osteogenic Differentiation and Bone Aging
Zimo Zhou, Kai Kang, Heran Wang, Boya Wen, Da Liu
Int. J. Biol. Sci. 2026; 22(1): 142-160. doi:10.7150/ijbs.122708
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Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma
Ran Huo, Chen-Zheng Gu, Yang Liu, Zi-Xian Wei, Te Liu, Jie Zhu, Lin Ding, Yu Liu, Chu-Yu Wang, Yi-Ni Li, Xin-Yi He, Wen-Jing Yang, Bei-Li Wang, Yun-Wei Wei, Wei Guo
Int. J. Biol. Sci. 2026; 22(1): 161-177. doi:10.7150/ijbs.113217
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SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy
Meimei Jiang, Jiehan Li, Ning Ding, Guiyun Jia, Siming Wu, Nannan Liu, Ying Kang, Ge Zhang, Jiawei Wu, Lingling Zhang, Yingjie Zhang
Int. J. Biol. Sci. 2026; 22(1): 178-200. doi:10.7150/ijbs.120007
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The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation
Renke He, Jiaying Mo, Zhongliang Lin, Kejing Zhu, Yishu Wang, Jiaen Yu, Haiyan Wu, Zhaoying Jiang, Qinyu Luo, Xueying Liu, Lin Yin, Chuanjin Yu, Jianzhong Sheng, Guolian Ding, Hefeng Huang
Int. J. Biol. Sci. 2026; 22(1): 201-219. doi:10.7150/ijbs.116803
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Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147+ extracellular vesicles promotes sorafenib resistance of hepatocellular carcinoma
Luomeng Qian, Zhiguang Fu, Ping Chen, Yuan Guo, Yutong Li, Yang Wang, Bo Wang, Qing Zhang, Qingjun Guo, Lidi Wu, Paulina Kucharzewska, Zhesheng Chen, Yongjun Piao, Sihe Zhang
Int. J. Biol. Sci. 2026; 22(1): 220-238. doi:10.7150/ijbs.125483
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Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4+ Macrophage Glycolysis
Jiali Ni, Ruowen Zhang, Yaqi Pu, Yaoqi He, Wen Hu, Lengge Su, Yayi Hou, Huan Dou
Int. J. Biol. Sci. 2026; 22(1): 239-257. doi:10.7150/ijbs.119052
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Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis
Jianpeng Chen, Dengying Wu, Chengbin Huang, Zijian Yan, Jiahao Wang, Siteng Li, Xuankuai Chen, Yanbin Zhu, Yingze Zhang
Int. J. Biol. Sci. 2026; 22(1): 308-326. doi:10.7150/ijbs.124043
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Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis
Hongyi Zhou, Zhongyin Ji, Heng Sun, Wanda Zhang, Yizhen Huang, Gu Jin, Haoyu Cai, Xu'an Huang, Jiafeng Dai, Junduo Zhao, Haojie Chen, Shunwu Fan, Yizheng Wu, Jianxiong Shen
Int. J. Biol. Sci. 2026; 22(1): 346-364. doi:10.7150/ijbs.114757
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Pan-cancer bone metastasis atlas at single-cell resolution identifies a distinct tumor-associated macrophage subset for mediating Denosumab-induced immunosensitization in lung cancer bone metastasis
Xianglin Hu, Nan Du, Yansha Song, Ke Lang, Wanning Tong, Qingrong Ye, Xuesi Liu, Haoyu Zheng, Mo Cheng, Yingzheng Ji, Haibo Wu, Minghe Zhang, Xinhong He, Yan Zhang, Xiaomeng Li, Yao Zhu, Kun Li, Weiluo Cai, Wangjun Yan, Wending Huang
Int. J. Biol. Sci. 2026; 22(1): 365-386. doi:10.7150/ijbs.119777
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Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways
Ying Zhang, Huan Lan, Xuechun Yu, Lin Zhuo, Bixin Zhao, Fang Liu, Lin An, Fan Zhang, Zhongqiu Liu, Caiyan Wang
Int. J. Biol. Sci. 2026; 22(1): 387-409. doi:10.7150/ijbs.121475
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Meox1 Promotes Cardiac Fibrosis and Pathological Remodeling following Myocardial Infarction through Cthrc1/p-Smad2/3 Signaling
Mian Zhang, Xiao-wen Meng, Yu-fan Yang, Xin-yu Chen, Yi-chan Wang, Jing-jie Wan, Jun Ding, Bi-ying Wang, Ke Peng, Fu-hai Ji
Int. J. Biol. Sci. 2026; 22(1): 410-425. doi:10.7150/ijbs.113825
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Loss of FAT1 drives cyclophosphamide resistance in breast cancer via the Wnt/β-Catenin pathway
Lijing Zhong, Dongyan Cao, Chen Zheng, Liyi Zhang, Yuxuan Xu, Shasha Zhao, Xiao Liu, Guiying Wei, Gengming Niu, Heming Xu, Xuan Tang, Jingyuan Wen, Paul W R Harris, Jian Zhang, Aina He, Dongxi Xiang
Int. J. Biol. Sci. 2026; 22(1): 447-465. doi:10.7150/ijbs.117161
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SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization
Pusheng Yang, Tao Wang, Yaxin Miao, Wenwen Liu, Yiping Zhu, Jing Sun
Int. J. Biol. Sci. 2026; 22(1): 466-480. doi:10.7150/ijbs.117146
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Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity
Junhui Chen, Qian Zhang, Jingnan Huang, Hengkai He, Yunmeng Bai, Yehai An, Mingjing Hao, Wentong Zhao, Wenhui Li, Sha Feng, Shiguang Yang, Jiaxian Liao, Yin Kwan Wong, Lingyun Dai, Qingfeng Du, Piao Luo, Jigang Wang
Int. J. Biol. Sci. 2026; 22(1): 481-499. doi:10.7150/ijbs.109757
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KRAS-Driven Hypertranscription and Metastatic Dissemination in Colorectal Cancer Could be Overcome by Targeting the NMHC IIA/ PLK1 Signaling Axis with a Novel Acridine Derivative
Dengbo Ji, Haizhao Yi, Ming Li, Zhaoya Gao, Rui Yang, Jingying Jia, Xinxin Cui, Can Song, Hanyang Wang, Mengyuan Shi, Yuhao Yan, Tongtong Geng, Xiangbao Meng, Zhongjun Li, Jin Gu
Int. J. Biol. Sci. 2026; 22(1): 500-518. doi:10.7150/ijbs.121816
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Reviews

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Therapy-induced mRNA, rRNA and tRNA methylation alterations confer tolerance phenotype in tumor cells: mechanism and implications
Anfeng Jiang, Shujie Liu, Zhiyuan Li, Xiongzhou Zhang, Minghao Duan, Bin Li
Int. J. Biol. Sci. 2026; 22(1): 86-110. doi:10.7150/ijbs.120764
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Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression
Qing Li, Siyuan Xia, Xian Zhang, Yuqiang Liu, Xue Xiao, Jinlin Yang
Int. J. Biol. Sci. 2026; 22(1): 258-279. doi:10.7150/ijbs.119630
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Mechanical Microenvironment in Tumor Immune Evasion: Bidirectional Regulation Between Matrix Stiffness and Immune Cells and Its Therapeutic Implications
Jing Ai, Huayao Li, Minpu Zhang, Jingyang Liu, Lijuan Liu, Changgang Sun
Int. J. Biol. Sci. 2026; 22(1): 280-307. doi:10.7150/ijbs.121356
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The Roles of TOPK in Tumorigenesis and Development: Structure, Mechanisms, Pathways, and Therapeutic Implications
Mengyu Zhao, Min Zhang, Mengrui Liang, Xinru Wang, Qipan Feng, Shengjie Wu, Xueli Tian, Ding Ding, Xiang Li, Kangdong Liu, Mee-Hyun Lee, Ran Zhao, Zigang Dong
Int. J. Biol. Sci. 2026; 22(1): 327-345. doi:10.7150/ijbs.122960
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Unravelling Resistance: Integrating Metabolism, Epigenetics, Immunology, and Proteostasis in Strategies against Kirsten Rat Sarcoma Viral Oncogene Homolog-mutant Colorectal Cancer
Jingyi Li, Na Song, Rui Ma, Xiujuan Qu
Int. J. Biol. Sci. 2026; 22(1): 426-446. doi:10.7150/ijbs.118831
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