◂ Last issue Next issue ▸ Archive Cover PDF
Volume 22 (1); 2026
Research Papers
LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer Dan Liu, Minxia Liu, Dongjin Lv, Yuxiang Li, Hongjuan Guo, Bingxiao Lu, Hao Leng, Ruyu Yan, Hongtao Yu, Tomas Blom, Kecheng Zhou
Int. J. Biol. Sci. 2026; 22(1): 1-24. doi:10.7150/ijbs.115365
Full text
PDF
PubMed
PMC
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys Xichen Song, Caijuan Li, Yang Yang, Chunhui Huang, Min Chen, Song Lin, Zhonghai Huang, Wei Wang, Kai Liao, Huiyi Wei, Lu Wang, Hao Xu, Yizhi Chen, Yingqi Lin, Jiawei Li, Zhen Dai, Wenguang Xie, Xiao Zheng, Jianhao Wu, Jiale Gao, Jiaxi Wu, Zhuchi Tu, Libing Zhou, Lu Huang, Chaoran Ren, Kwok-Fai So, Peng Yin, Huiming Yang, Shihua Li, Liangxue Lai, Xiao-Jiang Li, Sen Yan
Int. J. Biol. Sci. 2026; 22(1): 25-42. doi:10.7150/ijbs.122557
Full text
PDF
PubMed
PMC
Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis Huawei Chen, Xueyan Dai, Zhiwei Xiong, Huabin Cao, Chenghong Xing, Haotang Li, Xiaona Gao, Mingwen Hu, Fan Yang
Int. J. Biol. Sci. 2026; 22(1): 43-59. doi:10.7150/ijbs.123482
Full text
PDF
PubMed
PMC
The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects Zhenyu Chen, Yi Xu, Cheng Qu, Gang Luo, Zhuochang Cai, Hang Liu, Ziyang Sun, Chao Zhou, Juehong Li, Cunyi Fan
Int. J. Biol. Sci. 2026; 22(1): 60-85. doi:10.7150/ijbs.122706
Full text
PDF
PubMed
PMC
A SENP7-SIRT1-IL-10 Axis Driven by DeSUMOylation Promotes Breg Differentiation and Immune Evasion in Colorectal Cancer Yuhan Liao, Xinghua Zhuo, Yuan Huang, Huimeng Xu, Zhe Hao, Lanhui Huang, Haoxuan Zheng, Jun Zhou
Int. J. Biol. Sci. 2026; 22(1): 111-125. doi:10.7150/ijbs.118896
Full text
PDF
PubMed
PMC
Hepatic Stellate Cell-derived IL-11 Exacerbates Liver Fibrosis via Interplay between HSCs and Macrophages Yu Zhang, Fangfang He, Mozi Lei, Wenhui Fan, Xingyu Liu, Ying Tao, Weinan Wang, Bingshun Wang, Likun Gong, Jing Chen
Int. J. Biol. Sci. 2026; 22(1): 126-141. doi:10.7150/ijbs.119659
Full text
PDF
PubMed
PMC
H3K27 Acetylation-driven IGF2BP2 Mutates during the Aging of MSCs, thereby Influencing Osteogenic Differentiation and Bone Aging Zimo Zhou, Kai Kang, Heran Wang, Boya Wen, Da Liu
Int. J. Biol. Sci. 2026; 22(1): 142-160. doi:10.7150/ijbs.122708
Full text
PDF
PubMed
PMC
Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma Ran Huo, Chen-Zheng Gu, Yang Liu, Zi-Xian Wei, Te Liu, Jie Zhu, Lin Ding, Yu Liu, Chu-Yu Wang, Yi-Ni Li, Xin-Yi He, Wen-Jing Yang, Bei-Li Wang, Yun-Wei Wei, Wei Guo
Int. J. Biol. Sci. 2026; 22(1): 161-177. doi:10.7150/ijbs.113217
Full text
PDF
PubMed
PMC
SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy Meimei Jiang, Jiehan Li, Ning Ding, Guiyun Jia, Siming Wu, Nannan Liu, Ying Kang, Ge Zhang, Jiawei Wu, Lingling Zhang, Yingjie Zhang
Int. J. Biol. Sci. 2026; 22(1): 178-200. doi:10.7150/ijbs.120007
Full text
PDF
PubMed
PMC
The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation Renke He, Jiaying Mo, Zhongliang Lin, Kejing Zhu, Yishu Wang, Jiaen Yu, Haiyan Wu, Zhaoying Jiang, Qinyu Luo, Xueying Liu, Lin Yin, Chuanjin Yu, Jianzhong Sheng, Guolian Ding, Hefeng Huang
Int. J. Biol. Sci. 2026; 22(1): 201-219. doi:10.7150/ijbs.116803
Full text
PDF
PubMed
PMC
Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147+ extracellular vesicles promotes sorafenib resistance of hepatocellular carcinoma Luomeng Qian, Zhiguang Fu, Ping Chen, Yuan Guo, Yutong Li, Yang Wang, Bo Wang, Qing Zhang, Qingjun Guo, Lidi Wu, Paulina Kucharzewska, Zhesheng Chen, Yongjun Piao, Sihe Zhang
Int. J. Biol. Sci. 2026; 22(1): 220-238. doi:10.7150/ijbs.125483
Full text
PDF
PubMed
PMC
Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4+ Macrophage Glycolysis Jiali Ni, Ruowen Zhang, Yaqi Pu, Yaoqi He, Wen Hu, Lengge Su, Yayi Hou, Huan Dou
Int. J. Biol. Sci. 2026; 22(1): 239-257. doi:10.7150/ijbs.119052
Full text
PDF
PubMed
PMC
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis Jianpeng Chen, Dengying Wu, Chengbin Huang, Zijian Yan, Jiahao Wang, Siteng Li, Xuankuai Chen, Yanbin Zhu, Yingze Zhang
Int. J. Biol. Sci. 2026; 22(1): 308-326. doi:10.7150/ijbs.124043
Full text
PDF
PubMed
PMC
Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis Hongyi Zhou, Zhongyin Ji, Heng Sun, Wanda Zhang, Yizhen Huang, Gu Jin, Haoyu Cai, Xu'an Huang, Jiafeng Dai, Junduo Zhao, Haojie Chen, Shunwu Fan, Yizheng Wu, Jianxiong Shen
Int. J. Biol. Sci. 2026; 22(1): 346-364. doi:10.7150/ijbs.114757
Full text
PDF
PubMed
PMC
Pan-cancer bone metastasis atlas at single-cell resolution identifies a distinct tumor-associated macrophage subset for mediating Denosumab-induced immunosensitization in lung cancer bone metastasis Xianglin Hu, Nan Du, Yansha Song, Ke Lang, Wanning Tong, Qingrong Ye, Xuesi Liu, Haoyu Zheng, Mo Cheng, Yingzheng Ji, Haibo Wu, Minghe Zhang, Xinhong He, Yan Zhang, Xiaomeng Li, Yao Zhu, Kun Li, Weiluo Cai, Wangjun Yan, Wending Huang
Int. J. Biol. Sci. 2026; 22(1): 365-386. doi:10.7150/ijbs.119777
Full text
PDF
PubMed
PMC
Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways Ying Zhang, Huan Lan, Xuechun Yu, Lin Zhuo, Bixin Zhao, Fang Liu, Lin An, Fan Zhang, Zhongqiu Liu, Caiyan Wang
Int. J. Biol. Sci. 2026; 22(1): 387-409. doi:10.7150/ijbs.121475
Full text
PDF
PubMed
PMC
Meox1 Promotes Cardiac Fibrosis and Pathological Remodeling following Myocardial Infarction through Cthrc1/p-Smad2/3 Signaling Mian Zhang, Xiao-wen Meng, Yu-fan Yang, Xin-yu Chen, Yi-chan Wang, Jing-jie Wan, Jun Ding, Bi-ying Wang, Ke Peng, Fu-hai Ji
Int. J. Biol. Sci. 2026; 22(1): 410-425. doi:10.7150/ijbs.113825
Full text
PDF
PubMed
PMC
Loss of FAT1 drives cyclophosphamide resistance in breast cancer via the Wnt/β-Catenin pathway Lijing Zhong, Dongyan Cao, Chen Zheng, Liyi Zhang, Yuxuan Xu, Shasha Zhao, Xiao Liu, Guiying Wei, Gengming Niu, Heming Xu, Xuan Tang, Jingyuan Wen, Paul W R Harris, Jian Zhang, Aina He, Dongxi Xiang
Int. J. Biol. Sci. 2026; 22(1): 447-465. doi:10.7150/ijbs.117161
Full text
PDF
PubMed
PMC
SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization Pusheng Yang, Tao Wang, Yaxin Miao, Wenwen Liu, Yiping Zhu, Jing Sun
Int. J. Biol. Sci. 2026; 22(1): 466-480. doi:10.7150/ijbs.117146
Full text
PDF
PubMed
PMC
Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity Junhui Chen, Qian Zhang, Jingnan Huang, Hengkai He, Yunmeng Bai, Yehai An, Mingjing Hao, Wentong Zhao, Wenhui Li, Sha Feng, Shiguang Yang, Jiaxian Liao, Yin Kwan Wong, Lingyun Dai, Qingfeng Du, Piao Luo, Jigang Wang
Int. J. Biol. Sci. 2026; 22(1): 481-499. doi:10.7150/ijbs.109757
Full text
PDF
PubMed
PMC
KRAS-Driven Hypertranscription and Metastatic Dissemination in Colorectal Cancer Could be Overcome by Targeting the NMHC IIA/ PLK1 Signaling Axis with a Novel Acridine Derivative Dengbo Ji, Haizhao Yi, Ming Li, Zhaoya Gao, Rui Yang, Jingying Jia, Xinxin Cui, Can Song, Hanyang Wang, Mengyuan Shi, Yuhao Yan, Tongtong Geng, Xiangbao Meng, Zhongjun Li, Jin Gu
Int. J. Biol. Sci. 2026; 22(1): 500-518. doi:10.7150/ijbs.121816
Full text
PDF
PubMed
PMC
Reviews
Therapy-induced mRNA, rRNA and tRNA methylation alterations confer tolerance phenotype in tumor cells: mechanism and implications Anfeng Jiang, Shujie Liu, Zhiyuan Li, Xiongzhou Zhang, Minghao Duan, Bin Li
Int. J. Biol. Sci. 2026; 22(1): 86-110. doi:10.7150/ijbs.120764
Full text
PDF
PubMed
PMC
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression Qing Li, Siyuan Xia, Xian Zhang, Yuqiang Liu, Xue Xiao, Jinlin Yang
Int. J. Biol. Sci. 2026; 22(1): 258-279. doi:10.7150/ijbs.119630
Full text
PDF
PubMed
PMC
Mechanical Microenvironment in Tumor Immune Evasion: Bidirectional Regulation Between Matrix Stiffness and Immune Cells and Its Therapeutic Implications Jing Ai, Huayao Li, Minpu Zhang, Jingyang Liu, Lijuan Liu, Changgang Sun
Int. J. Biol. Sci. 2026; 22(1): 280-307. doi:10.7150/ijbs.121356
Full text
PDF
PubMed
PMC
The Roles of TOPK in Tumorigenesis and Development: Structure, Mechanisms, Pathways, and Therapeutic Implications Mengyu Zhao, Min Zhang, Mengrui Liang, Xinru Wang, Qipan Feng, Shengjie Wu, Xueli Tian, Ding Ding, Xiang Li, Kangdong Liu, Mee-Hyun Lee, Ran Zhao, Zigang Dong
Int. J. Biol. Sci. 2026; 22(1): 327-345. doi:10.7150/ijbs.122960
Full text
PDF
PubMed
PMC
Unravelling Resistance: Integrating Metabolism, Epigenetics, Immunology, and Proteostasis in Strategies against Kirsten Rat Sarcoma Viral Oncogene Homolog-mutant Colorectal Cancer Jingyi Li, Na Song, Rui Ma, Xiujuan Qu
Int. J. Biol. Sci. 2026; 22(1): 426-446. doi:10.7150/ijbs.118831
Full text
PDF
PubMed
PMC
Global reach, higher impact