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Volume 20 (11); 2024

Research Papers

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Nerve growth factor promote VCAM-1-dependent monocyte adhesion and M2 polarization in osteosarcoma microenvironment: Implications for larotrectinib therapy
Syuan-Ling Lin, Shang-Yu Yang, Chun-Hao Tsai, Yi-Chin Fong, Wei-Li Chen, Ju-Fang Liu, Chih-Yang Lin, Chih-Hsin Tang
Int. J. Biol. Sci. 2024; 20(11): 4114-4127. doi:10.7150/ijbs.95463
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METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the Cancer-Associated Fibroblasts
Jianlong Wu, Peng Ouyang, Rui Huang, Yao Cui, Zhihao Yang, Wei Xu, Rui Ma, Guoan Xiang, Wei Zeng, Wang Wu, Jian Li
Int. J. Biol. Sci. 2024; 20(11): 4128-4145. doi:10.7150/ijbs.95375
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N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis
Guoqing Zhu, Yi Xie, Zhixuan Bian, Ji Ma, Ni Zhen, Tianshu Chen, Jiabei Zhu, Siwei Mao, Xiaochen Tang, Li Liu, Song Gu, Miao Ding, Qiuhui Pan
Int. J. Biol. Sci. 2024; 20(11): 4146-4161. doi:10.7150/ijbs.92413
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FGF7 and FGF10 Promote Fate Transition of Human Epidermal Cell-derived Organoids to an Eccrine Gland Phenotype
Junhong Zhao, Lei Zhang, Yonghong Zhang, Manxiu Cao, Cangyu Wang, Anqi Hu, Leilei Cao, Qizhi Luo, Zhen You, Xueping Ma, Liang Gong, Cuiping Zhang, Haihong Li
Int. J. Biol. Sci. 2024; 20(11): 4162-4177. doi:10.7150/ijbs.97422
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The Antitumor and Sorafenib-resistant Reversal Effects of Ursolic Acid on Hepatocellular Carcinoma via Targeting ING5
Yin-Jie Fan, Fu-Zhi Pan, Zheng-Guo Cui, Hua-Chuan Zheng
Int. J. Biol. Sci. 2024; 20(11): 4190-4208. doi:10.7150/ijbs.97720
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m6A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle
Yongbo Pan, Huolun Feng, Jianlong Zhou, Wenxing Zhang, Yongfeng Liu, Jiabin Zheng, Junjiang Wang, Shan Gao, Yong Li
Int. J. Biol. Sci. 2024; 20(11): 4209-4221. doi:10.7150/ijbs.98535
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IL-6 signaling accelerates iron overload by upregulating DMT1 in endothelial cells to promote aortic dissection
Qiang Xie, Jianji Wang, Runqiao Li, Hao Liu, Yongliang Zhong, Qinfeng Xu, Yipeng Ge, Chengnan Li, Lizhong Sun, Junming Zhu
Int. J. Biol. Sci. 2024; 20(11): 4222-4237. doi:10.7150/ijbs.99511
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The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 antioxidant signaling
Jimena Nicolás-Morala, Marta Mascaraque-Checa, María Gallego-Rentero, Andrea Barahona, Edgar Abarca-Lachen, Elisa Carrasco, Yolanda Gilaberte, Salvador González, Ángeles Juarranz
Int. J. Biol. Sci. 2024; 20(11): 4238-4257. doi:10.7150/ijbs.94883
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The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage
Xiaobin Wen, Shanlong Tang, Fan Wan, Ruqing Zhong, Liang Chen, Hongfu Zhang
Int. J. Biol. Sci. 2024; 20(11): 4258-4276. doi:10.7150/ijbs.97263
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Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage
Yikui Liu, Fengzhen Cui, Aoqian Xu, Baofeng Wang, Yuxiao Ma, Qixiang Zhang, Qingfang Sun, Yongtao Zheng, Yuxiao Xue, Yuhao Sun, Liuguan Bian
Int. J. Biol. Sci. 2024; 20(11): 4277-4296. doi:10.7150/ijbs.93787
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PPARγ Agonist Pioglitazone Prevents Hypoxia-induced Cardiac Dysfunction by Reprogramming Glucose Metabolism
Yijin Wang, Ru Zhang, Qian Chen, Zhangwen Lei, Caiyu Shi, Yifei Pang, Shan'an Zhang, Linjie He, Longtao Xu, Jinliang Xing, Haitao Guo
Int. J. Biol. Sci. 2024; 20(11): 4297-4313. doi:10.7150/ijbs.98387
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Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway
Boshen Yang, Taixi Li, Zhixiang Wang, Yuankang Zhu, Kaifan Niu, Sien Hu, Zhiqi Lin, Xinjie Zheng, Xian Jin, Chengxing Shen
Int. J. Biol. Sci. 2024; 20(11): 4314-4340. doi:10.7150/ijbs.96489
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Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression
Yuhang Hu, Yang Li, Hewei Xiong, Ya Zhang, Fan Wang, Wenfeng Zhuo, Zhu Zeng, Yong Zhao, Hongda Wang, Ping Hu, Shengbo Han, Yan Huang, Guozheng Lv, Gang Zhao
Int. J. Biol. Sci. 2024; 20(11): 4341-4363. doi:10.7150/ijbs.94440
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RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression
Qiankun Ji, Zewei Tu, Junzhe Liu, Zhihong Zhou, Fengze Li, Xingen Zhu, Kai Huang
Int. J. Biol. Sci. 2024; 20(11): 4364-4381. doi:10.7150/ijbs.92595
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Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury
Hui Yao, Chaoyang Cai, Weijun Huang, Caizhen Zhong, Tianlun Zhao, Jiawei Di, Juliang Tang, Depeng Wu, Mao Pang, Lei He, Limin Rong, Bin Liu
Int. J. Biol. Sci. 2024; 20(11): 4382-4406. doi:10.7150/ijbs.98051
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Inhibition of α4β1 Integrin Activity by Small Tellurium Compounds Regulates PD-L1 Expression and Enhances Antitumor Effects
Abigael Chaouat, Yona Kalechman, Ophir Hay, Julia E. Manoim, Tal Lantner, Eitan Niderberg, Hagit Hauschner, Dvora Kenigsbuch Sredni, Tal Cohen, Agata Schlesinger, Ronia Nadler, Mira Barda-Saad, Elad Noy, Michael Albeck, Dan L. Longo, Benjamin Sredni
Int. J. Biol. Sci. 2024; 20(11): 4407-4423. doi:10.7150/ijbs.95350
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Tumor ABCC4-mediated release of PGE2 induces CD8+ T cell dysfunction and impairs PD-1 blockade in prostate cancer
Le Li, Zheng Chao, Hao Peng, Zhiquan Hu, Zhihua Wang, Xing Zeng
Int. J. Biol. Sci. 2024; 20(11): 4424-4437. doi:10.7150/ijbs.99716
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Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy
Shuai Chen, Qinghe Zeng, Xiurong Cai, Jiaming Xue, Guo Yin, Peng Song, Liming Tang, Christophe Klein, Frank Tacke, Adrien Guillot, Hanyang Liu
Int. J. Biol. Sci. 2024; 20(11): 4438-4457. doi:10.7150/ijbs.98362
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Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy
Junyan Wang, Haowen Zhuang, Lianqun Jia, Xinyong He, Sicheng Zheng, Kangshou Ji, Kang Xie, Tong Ying, Ying Zhang, Chun Li, Xing Chang
Int. J. Biol. Sci. 2024; 20(11): 4458-4475. doi:10.7150/ijbs.95853
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Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis
Ding Yang, Yan Sun, Pei Wen, Yaoxing Chen, Jing Cao, Xuelin Sun, Yulan Dong
Int. J. Biol. Sci. 2024; 20(11): 4476-4495. doi:10.7150/ijbs.97275
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Integrative alternative splicing analysis reveals new prognosis signature in B-cell acute lymphoblastic leukemia
Zhiyi Zhuo, Junfei Wang, Yonglei Zhang, Guoyu Meng
Int. J. Biol. Sci. 2024; 20(11): 4496-4512. doi:10.7150/ijbs.98899
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Olaparib combined with CDK12-IN-3 to promote genomic instability and cell death in ovarian cancer
Jianqiang Liang, Xuan Zhou, Lin Yuan, Tian Chen, Yicong Wan, Yi Jiang, Huangyang Meng, Mengting Xu, Lin Zhang, Wenjun Cheng
Int. J. Biol. Sci. 2024; 20(11): 4513-4531. doi:10.7150/ijbs.94568
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The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways
Yan Peng, Renping Xiong, Bo Wang, Xing Chen, Yalei Ning, Yan Zhao, Nan Yang, Jing Zhang, Changhong Li, Yuanguo Zhou, Ping Li
Int. J. Biol. Sci. 2024; 20(11): 4532-4550. doi:10.7150/ijbs.98856
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Mitochondrial pyruvate carrier 2 mitigates acute kidney injury via sustaining mitochondrial metabolism
Lin Wu, Qing Li, Fang Lu, Li Qian, Ying Pan, Chen Chen, Zhimin Huang, Suyan Duan, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan
Int. J. Biol. Sci. 2024; 20(11): 4551-4565. doi:10.7150/ijbs.98627
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FOXA1-dependent PUS1 regulates EIF3b stability in a non-enzymatic pathway mediating prostate cancer bone metastasis
Yongxin Wu, Shengmeng Peng, Bisheng Cheng, Haitao Zhong, Meifeng Cen, Jianhan Fu, Tianlong Luo, Zhenghui Guo, Yiming Lai, Hai Huang
Int. J. Biol. Sci. 2024; 20(11): 4566-4584. doi:10.7150/ijbs.100905
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Review

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mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular Carcinoma
Ling Mei, Huizhen Sun, Ying Yan, Huimin Ji, Qian Su, Le Chang, Lunan Wang
Int. J. Biol. Sci. 2024; 20(11): 4178-4189. doi:10.7150/ijbs.95894
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