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Volume 20 (14); 2024

Research Papers

The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin Wenlin Li, Kun Xu, Ming Lan, Junpeng Gao, Lin Dou, Yao Yang, Que Wang, Mingjing Yan, Sainan Li, Qinan Ma, Weimeng Tian, Beidong Chen, Ju Cui, Xiyue Zhang, Jianping Cai, Hua Wang, Liang Sun, Jian Li, Xiuqing Huang, Tao Shen Int. J. Biol. Sci. 2024; 20(14): 5396-5414. doi:10.7150/ijbs.97418 Full text PDF PubMed PMC

Heterophyllin B enhances transcription factor EB-mediated autophagy and alleviates pyroptosis and oxidative stress after spinal cord injury Haojie Zhang, Wei Wang, Xinli Hu, Zheng Wang, Junsheng Lou, Peng Cui, Xuan Zhao, Yu Wang, Xiaolong Chen, Shibao Lu Int. J. Biol. Sci. 2024; 20(14): 5415-5435. doi:10.7150/ijbs.97669 Full text PDF PubMed PMC

N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1^-/- Mice and Early Life Stress Model Rats Han-Byeol Kim, Yu-Jin Kim, Ye-Ji Lee, Ji-Young Yoo, Yoori Choi, Eun-Mee Kim, Sang Won Suh, Ran-Sook Woo Int. J. Biol. Sci. 2024; 20(14): 5450-5473. doi:10.7150/ijbs.97723 Full text PDF PubMed PMC

SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells José Manuel García-Martínez, Ana Chocarro-Calvo, Javier Martínez-Useros, Nerea Regueira-Acebedo, María Jesús Fernández-Aceñero, Alberto Muñoz, María Jesús Larriba, Custodia García-Jiménez Int. J. Biol. Sci. 2024; 20(14): 5495-5509. doi:10.7150/ijbs.95875 Full text PDF PubMed PMC

Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing Chia-Yen Dai, Ying-Ming Tsai, Chao-Yuan Chang, Hung-Pei Tsai, Kuan-Li Wu, Yu-Yuan Wu, Ling-Yu Wu, Shu-Fang Jian, Pei-Hsun Tsai, Chai-Tung Ong, Chien-Hui Sun, Ya-Ling Hsu Int. J. Biol. Sci. 2024; 20(14): 5531-5547. doi:10.7150/ijbs.99176 Full text PDF PubMed PMC

Targeting PLCG2 Suppresses Tumor Progression, Orchestrates the Tumor Immune Microenvironment and Potentiates Immune Checkpoint Blockade Therapy for Colorectal Cancer Xueliang Zhou, Joshua Lin, Yanfei Shao, Huang Zheng, Yi Yang, Shuchun Li, Xiaodong Fan, Hiju Hong, Zhihai Mao, Pei Xue, Sen Zhang, Jing Sun Int. J. Biol. Sci. 2024; 20(14): 5548-5575. doi:10.7150/ijbs.98200 Full text PDF PubMed PMC

ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism Shen You, Ming-Jin Wang, Zhen-Yan Hou, Wei-Da Wang, Zhi-Hui Zhang, Ting-Ting Du, Shu-Ying Li, Yi-Chen Liu, Ni-Na Xue, Xiao-Min Hu, Xiao-Guang Chen, Ming Ji Int. J. Biol. Sci. 2024; 20(14): 5576-5593. doi:10.7150/ijbs.96651 Full text PDF PubMed PMC

OAS3 Deubiquitination Due to E3 Ligase TRIM21 Downregulation Promotes Epithelial Cell Apoptosis and Drives Sepsis-induced Acute Lung Injury Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Yihang Fang, Jinlian Liu, Ke Song, Lina Tuolihong, Zirui Zuo, Qi He, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Zhifeng Liu, Xiaohua Guo Int. J. Biol. Sci. 2024; 20(14): 5594-5607. doi:10.7150/ijbs.96089 Full text PDF PubMed PMC

Breast cancer-derived CAV1 promotes lung metastasis by regulating integrin α6β4 and the recruitment and polarization of tumor-associated neutrophils Qing Lin, Siwen Zong, Yi Wang, Youjia Zhou, Keqin Wang, Fuxiu Shi, Jiayang Wang, Mingrui Feng, Wenting Luo, Lifang Zhang, Hui Lin, Lixia Xiong Int. J. Biol. Sci. 2024; 20(14): 5695-5714. doi:10.7150/ijbs.94153 Full text PDF PubMed PMC

SUMOylation modification of HNRNPK at the K422 site promotes invasion in glioblastoma Wenguo Zhao, Jiazheng Wang, Feihu Zhao, Yaquan Li, Zhuo Li, Xingang Li, Anjing Chen Int. J. Biol. Sci. 2024; 20(14): 5715-5730. doi:10.7150/ijbs.102051 Full text PDF PubMed PMC

Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1 Juanyong Zhao, Haiyang Liu, Qian Chen, Ming Xia, Lili Wan, Weihong Yu, Chenxi Liu, Xiaomiao Hao, Chengyuan Tang, Guochun Chen, Yu Liu, Fang Yuan, Hong Liu Int. J. Biol. Sci. 2024; 20(14): 5731-5746. doi:10.7150/ijbs.99738 Full text PDF PubMed PMC

AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells YounHa Kim, Sang Bum Kim, Ho Lee, Doyeun Kim, Soon Sun Bak, Ina Yoon, Seongmin Cho, Seung Jae Jeong, Yoon Jeon, Jina Kim, Ji-hee Kim, Soohwan Oh, Khas-Erdene Battogtokh, Min Chul Park, Young Kwan Sung, Sunghoon Kim Int. J. Biol. Sci. 2024; 20(14): 5764-5778. doi:10.7150/ijbs.101127 Full text PDF PubMed PMC

Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression Xing Chang, Hao Zhou, Jinlin Hu, Teng Ge, Kunyang He, Ye Chen, Rongjun Zou, Xiaoping Fan Int. J. Biol. Sci. 2024; 20(14): 5793-5811. doi:10.7150/ijbs.102424 Full text PDF PubMed PMC

Reviews

Cold Atmospheric Plasma: Possible Cure of Autoimmune Disorders and Cancer via Attenuating Inflammation Xiaofeng Dai, Shuo Feng, Yan Zheng Int. J. Biol. Sci. 2024; 20(14): 5436-5449. doi:10.7150/ijbs.102445 Full text PDF PubMed PMC

Targeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap Md. Zamshed Alam Begh, Jishan Khan, Mehrukh Zehravi, Sherouk Hussein Sweilam, A. Dinesh Raja, A. Muthukumar, M Akiful Haque, Nihar Ranjan Kar, Laliteshwar Pratap Singh, B. Dharani Priya, Mohammed Ali Alshehri, Irfan Ahmad, Sojin Kang, Seungjoon Moon, Moon Nyeo Park, Talha Bin Emran, Bonglee Kim Int. J. Biol. Sci. 2024; 20(14): 5474-5494. doi:10.7150/ijbs.102032 Full text PDF PubMed PMC

Recent Trends in anti-tumor mechanisms and molecular targets of celastrol Yongping Zhu, Yuqing Meng, Junzhe Zhang, Rui Liu, Shengnan Shen, Liwei Gu, Yin-kwan Wong, Ang Ma, Xin Chai, Ying Zhang, Yanqing Liu, Jigang Wang Int. J. Biol. Sci. 2024; 20(14): 5510-5530. doi:10.7150/ijbs.99592 Full text PDF PubMed PMC

Harnessing the Anti-Inflammatory Properties of Polyphenols in the Treatment of Inflammatory Bowel Disease Diego Liviu Boaru, Oscar Fraile-Martinez, Diego De Leon-Oliva, Cielo Garcia-Montero, Patricia De Castro-Martinez, Alejandro Miranda-Gonzalez, Miguel A Saez, Leticia Muñon-Zamarron, Elisa Castillo-Ruiz, Silvestra Barrena-Blázquez, Rafael Cañonez-Zafra, Miguel Ángel Alvarez-Mon, Maria V Toledo-Lobo, Ana M Minaya-Bravo, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Jose V Saz, Agustin Albillos, Melchor Alvarez-Mon, Luis G Guijarro, Miguel A Ortega Int. J. Biol. Sci. 2024; 20(14): 5608-5672. doi:10.7150/ijbs.98107 Full text PDF PubMed PMC

Overcoming Barriers in Photodynamic Therapy Harnessing Nanogenerators Strategies Yi Zhou, Pingjin Zou, Xingmin Chen, Ping Chen, Min Shi, Jinyi Lang, Meihua Chen Int. J. Biol. Sci. 2024; 20(14): 5673-5694. doi:10.7150/ijbs.100317 Full text PDF PubMed PMC

New insights into non-small cell lung cancer bone metastasis: mechanisms and therapies Man Xue, Li Ma, Pengpeng Zhang, Hui Yang, Zhaoxia Wang Int. J. Biol. Sci. 2024; 20(14): 5747-5763. doi:10.7150/ijbs.100960 Full text PDF PubMed PMC

Micro(nano)plastics: an Emerging Burden for Human Health Isabella Donisi, Antonino Colloca, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D'Onofrio Int. J. Biol. Sci. 2024; 20(14): 5779-5792. doi:10.7150/ijbs.99556 Full text PDF PubMed PMC

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