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Volume 21 (6); 2025
Editorial
Mechanometabolic Regulation in Cancer Progression: Lessons from Fibrotic Remodeling Chen-Yueh Wen, Po-Hung Chen, Renin Chang, Su-Boon Yong, Chin-Yuan Yii, Yen Chin, Chia-Jung Li
Int. J. Biol. Sci. 2025; 21(6): 2672-2675. doi:10.7150/ijbs.112325
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Research Papers
Integrin β3-mediated platelet extracellular vesicle adhesion facilitates vascular smooth muscle cell dysfunction in postinjury intimal hyperplasia Fei Zhuang, Zhi-tong Liu, Guo Zhou, Feng Liang, Ying-hua Wang, Long Chen, Wei-feng Zhang, Ling-hong Shen, Yan-qiao Lu, Huan-huan Huo, Xin Shi, Liang Fang, Ben He
Int. J. Biol. Sci. 2025; 21(6): 2380-2395. doi:10.7150/ijbs.101391
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PPARG Activation of Fatty Acid Metabolism Drives Resistance to Anti-HER2 Therapies in HER2-Positive Breast Cancer Min Xiong, Douwaner Liu, Xuliren Wang, Hengyu Ren, Weiru Chi, Bingqiu Xiu, Qi Zhang, Jiayu Zhang, Liyi Zhang, Zehao Wang, Ming Chen, Jingyan Xue, Yayun Chi, Jiong Wu
Int. J. Biol. Sci. 2025; 21(6): 2396-2414. doi:10.7150/ijbs.99275
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Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy Jiaqi Xu, Xianhuang Zeng, Junsong Huang, Shuangshuang Ma, Kun Li, Siqi Yang, Wajeeha Naz, Tanzeel Yousaf, Sen Yuan, Yang Liu, Jing Zhang, Chaozhi Liu, Chenyi Liu, Zixu Zhai, Mingxiong Guo, Guihong Sun
Int. J. Biol. Sci. 2025; 21(6): 2415-2429. doi:10.7150/ijbs.105447
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Cardiovascular Mettl3 Deficiency Causes Congenital Cardiac Defects and Postnatal Lethality in Mice Qianqian Feng, Lihua Qi, Jiaqi Huang, Zhigang Dong, Fang Yu, Jing Zhang, Jun Zhan, Hongquan Zhang, Wengong Wang, Yong Zhou, Zhongzhou Yang, Yuan Zhou, Wei Kong, Yi Fu
Int. J. Biol. Sci. 2025; 21(6): 2430-2445. doi:10.7150/ijbs.100941
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A Novel Mouse Model of Depression: Advantages in Immune Research and Clinical Translation Jing Xiong, Xian-Qiang Zhang, Ji-Tao Li, Chi Ren, Tian Shen, Yun-Ai Su, Tian-Mei Si
Int. J. Biol. Sci. 2025; 21(6): 2446-2461. doi:10.7150/ijbs.104950
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The SGK3/GSK3β/β-catenin signaling promotes breast cancer stemness and confers resistance to alpelisib therapy Tingting Kang, Yuanfang Wang, Yaxin Jiang, Shunjie Chen, Na Lin, Minyan Guo, Haotu Zhu, Di Tang, Xiaofan Ding, Mian He
Int. J. Biol. Sci. 2025; 21(6): 2462-2475. doi:10.7150/ijbs.104850
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PROTAC-Surufatinib Suppresses Pancreatic Neuroendocrine Neoplasms Progression by Inducing Ferroptosis through Inhibiting WNT/β-catenin Pathway Mediated by HMOX1 Bingyan Xue, Lijun Yan, Mujie Ye, Danyang Gu, Jianqiang Qian, Na He, Ping Hu, Feiyu Lu, Xintong Lu, Min Liu, Lin Xu, Jianan Bai, Yan Wang, Guoqin Zhu, Qiyun Tang
Int. J. Biol. Sci. 2025; 21(6): 2476-2492. doi:10.7150/ijbs.106357
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Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation Ting-Kuo Chang, Lin-Chu Huang, Yueh-Hsiung Kuo, Chun-Hao Tsai, Hsien-Te Chen, Yi-Syuan Wu, Chih-Hsin Tang, Chen-Ming Su
Int. J. Biol. Sci. 2025; 21(6): 2493-2507. doi:10.7150/ijbs.107343
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HDC/histamine Signaling Axis Drives Macrophage Reprogramming to Promote Angiogenesis in Hindlimb-Ischemic Mice Dili Sun, Jianfu Zhu, Gaofeng Zeng, Xiyang Yang, Xiaowei Zhu, Diyaerjiang Aierken, Zhaocheng Shi, Suling Ding, Junbo Ge, Hai Hu, Xiangdong Yang
Int. J. Biol. Sci. 2025; 21(6): 2508-2530. doi:10.7150/ijbs.105148
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PSMG2 role in tumorigenesis and stemness mediated by protein accumulation, reticulum stress and autophagy Asunción Espinosa-Sánchez, Elena Blanco-Alcaina, Amancio Carnero
Int. J. Biol. Sci. 2025; 21(6): 2531-2549. doi:10.7150/ijbs.105263
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Targeting HCG18 counteracts ferroptosis resistance via blocking the miR-30a-5p/RRM2/GSS pathway in hepatocellular carcinoma Tian Zhan, Yawei Liu, Shuoke Duan, Chen Lu, Heng Jia, Ming Jin, Jie Li, Xinru Du, Sizheng Sun, Yuan Li, Jianping Zhang
Int. J. Biol. Sci. 2025; 21(6): 2550-2567. doi:10.7150/ijbs.104127
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Cgref1 is a CREB-H-regulated hepatokine that promotes hepatic de novo lipogenesis by mediating epididymal fat insulin resistance Pearl Chan, Pak-Hin Hinson Cheung, Xiao-Zhuo Kang, Yun Cheng, Chi-Ming Wong, Dong-Yan Jin, Chi-Ping Chan
Int. J. Biol. Sci. 2025; 21(6): 2568-2588. doi:10.7150/ijbs.97008
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EMC2 promotes breast cancer progression and enhances sensitivity to PDK1/AKT inhibition by deubiquitinating ENO1 Shihan Xiao, Shangxuan Jiang, Chengxu Wen, Han Wang, Wenxiang Nie, Jianguo Zhao, Bo Zhang
Int. J. Biol. Sci. 2025; 21(6): 2629-2646. doi:10.7150/ijbs.109192
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Antitumor Effects of Sesamin via the LincRNA-p21/STAT3 Axis in Human Bladder Cancer: Inhibition of Metastatic Progression and Enhanced Chemosensitivity Chao-Yen Ho, Thomas I-Sheng Hwang, Pei-Wen Peng, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Peng-Hui Chang, Wei-Chien Huang, Chung-Hua Hsu, Tsai-Ju Chien, An-Chen Chang
Int. J. Biol. Sci. 2025; 21(6): 2692-2706. doi:10.7150/ijbs.103274
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NAMPT Impairs Vascular Permeability in Periodontitis by Influencing FASN-mediated Lipogenesis Yijing Xiao, Jiahui Ma, Zirui Li, Huiqing Gou, Xu Chen, Yi Zhou, Ming Shen, Lu Li, Yan Xu
Int. J. Biol. Sci. 2025; 21(6): 2707-2724. doi:10.7150/ijbs.104485
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Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As3+)-Induced Malignant Transformation by Antagonizing TOX Expression Wenxuan Zhang, Ziwei Wang, Yao Fu, Chitra Thakur, Haoyan Ji, Zhuoyue Bi, Yiran Qiu, Millie Elangbam, John Haley, Fei Chen
Int. J. Biol. Sci. 2025; 21(6): 2747-2761. doi:10.7150/ijbs.107268
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SNX17 mediates STAT3 activation to promote hepatocellular carcinoma progression via a retromer dependent mechanism Yuqi Liu, Wei Tian, Chao Ge, Canxue Zhang, Zhihong Huang, Chi Zhang, Yue Yang, Hua Tian
Int. J. Biol. Sci. 2025; 21(6): 2762-2779. doi:10.7150/ijbs.110506
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Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response Yuzhou Xue, Yuce Peng, Ling Jin, Lin Liu, Qian Liu, Xiaofan Yuan, Jingyu Wang, Mingming Zhao, Wenming Zhang, Suxin Luo, Yuanjing Li, Minghao Luo, Longxiang Huang
Int. J. Biol. Sci. 2025; 21(6): 2780-2805. doi:10.7150/ijbs.102675
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Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis Sai Tian, Tianyu Wu, Zhou Zhang, Shanshan Lv, Xinlu Ji, Zhicong Zhao, Xuelin Ma, Jin Wang, Yan Bi
Int. J. Biol. Sci. 2025; 21(6): 2824-2842. doi:10.7150/ijbs.99617
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VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7 Qinghua Wang, Xin'an Wang, Hanchu Ye, Yicong Yao, Haopeng Li, Xin Qin, Yan Zhao, Wei Jiang, Mingming Xu, Tong Zi, Xilei Li, Xi Chen, Juan Zhou, Gang Wu
Int. J. Biol. Sci. 2025; 21(6): 2843-2863. doi:10.7150/ijbs.109271
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YAP-activated NAT10 promotes hepatoblastoma progression by activating the pentose phosphate pathway Lingxiao Wang, Shiguang Yang, Jie Li, Yuan Fang, Mengzhou Guo, Xiaojing Du, Li Song, Sinuo Chen, Xingxing Zhang, Zhuoran Qi, Kaihui Zhang, Bei Lv, Jinglin Xia
Int. J. Biol. Sci. 2025; 21(6): 2864-2879. doi:10.7150/ijbs.109552
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Reviews
Targeting Glycolysis for Treatment of Breast Cancer Resistance: Current Progress and Future Prospects Zixu Niu, Jing He, Siyuan Wang, Bingjian Xue, Hao Zhang, Ruohan Hou, Zimeng Xu, Jing Sun, Fucheng He, Xinhong Pei
Int. J. Biol. Sci. 2025; 21(6): 2589-2605. doi:10.7150/ijbs.109803
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Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies Feifei Li, Chunfang Gao, Yan Huang, Yu Qiao, Hongxiao Xu, Sheng Liu, Huangan Wu
Int. J. Biol. Sci. 2025; 21(6): 2606-2628. doi:10.7150/ijbs.108803
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Conception and Concern: A Review of Breast Cancer Risk in Assisted Reproductive Technology Zijie Guo, Ziyu Zhu, Xixi Lin, Kevin Matthew Zhang, Qingliang Wu, Shenkangle Wang, Mingpeng Luo, Xiaona Lin, Linbo Wang, Jichun Zhou
Int. J. Biol. Sci. 2025; 21(6): 2647-2671. doi:10.7150/ijbs.105357
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From molecular design to clinical translation: dual-targeted CAR-T strategies in cancer immunotherapy Zhenrong Wang, Mengyi Wang, Mengting Wang, Ruijie Zhou, Xiaotong Deng, Xin Ouyang, Minghui Chu, Xinyu Wei, Lei Yang, Jinbiao Liu, Yao Xu
Int. J. Biol. Sci. 2025; 21(6): 2676-2691. doi:10.7150/ijbs.108036
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FMRFamide-like peptides (FaLPs) - an overview of diverse physiological roles in insects and other arthropods Szymon Chowański, Jan Lubawy, Joanna Pacholska-Bogalska, Lapo Ragionieri, Arkadiusz Urbański, Monika Szymczak-Cendlak, Karolina Walkowiak-Nowicka, Paweł Marciniak
Int. J. Biol. Sci. 2025; 21(6): 2725-2746. doi:10.7150/ijbs.106382
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Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review Guobin Hou, Jingjun Wang, Shuai Liu, Duo Gao, Yiming Xu, Yimin Zhuang, Wenzhuo Dong, Yi Yue, Jinni Bai, Shangru Li, Jiaying Ma, Mengmeng Li, Wei Wang, Yajing Wang, Shengli Li, Zhijun Cao
Int. J. Biol. Sci. 2025; 21(6): 2806-2823. doi:10.7150/ijbs.104074
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The mechanism of histone modifications in regulating enzalutamide sensitivity in advanced prostate cancer Zhite Zhao, Yuming Jing, Zhicheng Xu, Hongfan Zhao, Xinglin He, Tong Lu, Jianhui Bai, Weijun Qin, Lijun Yang
Int. J. Biol. Sci. 2025; 21(6): 2880-2890. doi:10.7150/ijbs.109638
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