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Volume 20 (13); 2024

Research Papers

Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic Diseases Yu Zhong, Biao Wei, Wenbiao Wang, Junzhe Chen, Wenjing Wu, Liying Liang, Xiao-Ru Huang, Cheuk-Chun Szeto, Xueqing Yu, David J. Nikolic-Paterson, Hui-Yao Lan Int. J. Biol. Sci. 2024; 20(13): 5027-5042. doi:10.7150/ijbs.98839 Full text PDF PubMed PMC

AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment—Efficacy and Mechanism Tao Dong, Leonard Barasa, Xin Yu, Wenlu Ouyang, Liujiazi Shao, Chao Quan, Su He Wang, Jifeng Zhang, Morgan Salmon, Allan Tsung, Hasan B. Alam, Jianjie Ma, Paul R. Thompson, Yongqing Li Int. J. Biol. Sci. 2024; 20(13): 5043-5055. doi:10.7150/ijbs.97166 Full text PDF PubMed PMC

Chimerization of human ESC-derived extraembryonic cells with the mouse blastocyst Siyi Fu, Borong Huang, Enqin Li, Xiaoling Xu, Ren-He Xu Int. J. Biol. Sci. 2024; 20(13): 5056-5069. doi:10.7150/ijbs.99519 Full text PDF PubMed PMC

PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer Yujia Song, Xiaohui Wang, Yuqi Sun, Nianhua Yu, Yajie Tian, Jinli Han, Xianjun Qu, Xinfeng Yu Int. J. Biol. Sci. 2024; 20(13): 5070-5086. doi:10.7150/ijbs.99804 Full text PDF PubMed PMC

HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA Wenbo Jia, Liang Yu, Bin Xu, Yanzhi Feng, Jinyi Wang, Deming Zhu, Chao Xu, Litao Liang, Yongping Zhou, Lianbao Kong, Wenzhou Ding Int. J. Biol. Sci. 2024; 20(13): 5087-5108. doi:10.7150/ijbs.95276 Full text PDF PubMed PMC

KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300 Wendan Yu, Shilong Han, Sheng Hu, Liyuan Ru, Chunyu Hua, Guoqing Xue, Guohui Zhang, Kuan Lv, Hanxiao Ge, Meiyi Wang, Lina Zheng, Jie Zhou, Shuai Hou, Yun Teng, Wuguo Deng, Wei Guo Int. J. Biol. Sci. 2024; 20(13): 5127-5144. doi:10.7150/ijbs.98668 Full text PDF PubMed PMC

Exploring the Mechanism of Ferroptosis Induction by Sappanone A in Cancer: Insights into the Mitochondrial Dysfunction Mediated by NRF2/xCT/GPX4 Axis Junyan Wang, Haowen Zhuang, Xiaocui Yang, Zhijiang Guo, Kainan Zhou, Nanyang Liu, Yang An, Ye Chen, Zhongzheng Zhang, Mengyuan Wang, Jinhong Chen, Chun Li, Xing Chang Int. J. Biol. Sci. 2024; 20(13): 5145-5161. doi:10.7150/ijbs.96748 Full text PDF PubMed PMC

HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling Yiming Zhang, Ruilin Pan, Kun Li, Lek Hang Cheang, Jing Zhao, Zhangfeng Zhong, Shaoping Li, Jinghao Wang, Xiaofang Zhang, Yanmei Cheng, Xiaofei Zheng, Rongrong He, Huajun Wang Int. J. Biol. Sci. 2024; 20(13): 5162-5190. doi:10.7150/ijbs.100015 Full text PDF PubMed PMC

Integrated analysis of tumor and adjacent non-tumor proteomic data reveals SERPINH1 as a recurrence biomarker and drug target in hepatocellular carcinoma Yushan Hou, Yiming Zhang, Kun Zheng, Han Wang, Yingying Zhou, Yuanjun Zhai, Fuchu He, Chunyan Tian, Aihua Sun Int. J. Biol. Sci. 2024; 20(13): 5191-5207. doi:10.7150/ijbs.99734 Full text PDF PubMed PMC

USP44 inactivation accelerates the progression of thyroid cancer by inducing ubiquitylation and degradation of p21 Yan Liu, Mengmeng Yuan, Xinxin Xu, Huini Yang, Yao Yao, Peng Hou, Wei Yu, Meiju Ji Int. J. Biol. Sci. 2024; 20(13): 5223-5238. doi:10.7150/ijbs.99817 Full text PDF PubMed PMC

Amlexanox Enforces Osteogenic Differentiation and Bone Homeostasis Through Inhibiting Ubiquitin-Dependent Degradation of β-Catenin Qian He, Zhouboran Liu, Xuan Xia, Jun Zeng, Yuling Liu, Jingqiong Xun, Meilu Liu, Yueming Mei, Ruchun Dai Int. J. Biol. Sci. 2024; 20(13): 5254-5271. doi:10.7150/ijbs.101507 Full text PDF PubMed PMC

Identification of miR-6794-3p as a suppressor in pancreatic cancer metastasis Ha Gyeong Kim, Yunmi Cho, Jae-Seon Lee, Eun-Taex Oh, Heon Joo Park Int. J. Biol. Sci. 2024; 20(13): 5272-5292. doi:10.7150/ijbs.98490 Full text PDF PubMed PMC

Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice Wenbo Zhang, Longwei Gao, Xiaodan Zhang, Yashuang Weng, Yan Du, Yan-Li Sun, Hongwei Wei, Tiantian Hao, Yuezhou Chen, Xiaoyan Liang, Meijia Zhang Int. J. Biol. Sci. 2024; 20(13): 5312-5329. doi:10.7150/ijbs.99936 Full text PDF PubMed PMC

USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway Jie Wang, Lang Gan, Fenghao Liu, Qin Yang, Qingsong Deng, Di Jiang, Chengcheng Zhang, LeiDa Zhang, XiaoJun Wang Int. J. Biol. Sci. 2024; 20(13): 5343-5362. doi:10.7150/ijbs.92278 Full text PDF PubMed PMC

Leveraging Patient-Derived Organoids for Personalized Liver Cancer Treatment Jianhua Rao, Chao Song, Yangyang Hao, Zaozao Chen, Sidu Feng, Shihui Xu, Xiaoyue Wu, Zhengfeng Xuan, Ye Fan, Wenzhu Li, Junda Li, Yong Ren, Jian Li, Feng Cheng, Zhongze Gu Int. J. Biol. Sci. 2024; 20(13): 5363-5374. doi:10.7150/ijbs.96317 Full text PDF PubMed PMC

NUSAP1 is Upregulated by Estrogen to Promote Lung Adenocarcinoma Growth and Serves as a Therapeutic Target Shaoping Zhang, Xiaozhen Zhang, Wenjian Huang, Ganling Jiang, Yuanxin Mo, Liuxia Wei, Pingming Fan, Maojian Chen, Wei Jiang Int. J. Biol. Sci. 2024; 20(13): 5375-5395. doi:10.7150/ijbs.100188 Full text PDF PubMed PMC

Reviews

A new perspective on the therapeutic potential of tumor metastasis: targeting the metabolic interactions between TAMs and tumor cells Xuan Zhao, Tong Ren, Sijin Li, Xu Wang, Rui Hou, Zhangchun Guan, Dan Liu, Junnian Zheng, Ming Shi Int. J. Biol. Sci. 2024; 20(13): 5109-5126. doi:10.7150/ijbs.99680 Full text PDF PubMed PMC

Deubiquitinases in Ovarian Cancer: Role in Drug Resistance and Tumor Aggressiveness Giovanni Luca Beretta, Matteo Costantino, Luca Mirra, Pietro Pettinari, Paola Perego Int. J. Biol. Sci. 2024; 20(13): 5208-5222. doi:10.7150/ijbs.100355 Full text PDF PubMed PMC

Unveiling the Role of Mechanical Microenvironment in Hepatocellular Carcinoma: Molecular Mechanisms and Implications for Therapeutic Strategies Jiachen Hong, Jiongjie Yu, Damiano Buratto, Wei Chen, Ruhong Zhou, Sunbin Ling, Xiao Xu Int. J. Biol. Sci. 2024; 20(13): 5239-5253. doi:10.7150/ijbs.102706 Full text PDF PubMed PMC

Three-Dimensional In Vitro Cell Cultures as a Feasible and Promising Alternative to Two-Dimensional and Animal Models in Cancer Research Andrea Esposito, Alessandra Ferraresi, Letizia Vallino, Beatrice Garavaglia, Danny N. Dhanasekaran, Ciro Isidoro Int. J. Biol. Sci. 2024; 20(13): 5293-5311. doi:10.7150/ijbs.96469 Full text PDF PubMed PMC

Molecular changes in intraocular fluid: implications for myopia Zewei Zhang, Lingfeng Lv, Dongmei Chen, Fang Li, Jibo Zhou Int. J. Biol. Sci. 2024; 20(13): 5330-5342. doi:10.7150/ijbs.101438 Full text PDF PubMed PMC

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