Previous issue | Next issue | Archive   

Volume 18 (9); 2022

Research Papers

Graphic abstract

Insulin Directs Dichotomous Translational Regulation to Control Human Pluripotent Stem Cell Survival, Proliferation and Pluripotency
Xiaoxiao Zhou, Zhili Ren, Jiaqi Xu, Chunhao Deng, Zhaoying Zhang, Carlos Godoy-Parejo, Faxiang Xu, Esther Chi Cheng Huang, Jiajia Wang, Zheyu Cai, Weiwei Liu, Guang Hu, Guokai Chen
Int. J. Biol. Sci. 2022; 18(9): 3562-3575. doi:10.7150/ijbs.71199
[Abstract] [Full text] [PDF]


Graphic abstract

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma
Jing Li, Tao Yang, Qihong Wang, Yuedan Li, Haiyan Wu, Mei Zhang, Hong Qi, Hongxin Zhang, Jinfeng Li
Int. J. Biol. Sci. 2022; 18(9): 3576-3591. doi:10.7150/ijbs.68216
[Abstract] [Full text] [PDF]


Graphic abstract

PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer
Ya-Ge Chen, Hong-Xia Liu, Ya Hong, Peng-Zhen Dong, Shi-Yu Liu, Ying-Ran Gao, Dan Lu, Tao Li, Da-Yong Wang, Dong-Dong Wu, Xin-Ying Ji
Int. J. Biol. Sci. 2022; 18(9): 3605-3620. doi:10.7150/ijbs.70394
[Abstract] [Full text] [PDF]


Graphic abstract

NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation
Jiatian Lin, Xiangling Chen, Hongjian Yu, Shasha Min, Yequn Chen, Zesong Li, Xina Xie
Int. J. Biol. Sci. 2022; 18(9): 3621-3635. doi:10.7150/ijbs.70972
[Abstract] [Full text] [PDF]


Graphic abstract

Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Int. J. Biol. Sci. 2022; 18(9): 3636-3652. doi:10.7150/ijbs.71870
[Abstract] [Full text] [PDF]


Graphic abstract

Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice
Limanjaya Anita, Guo Nan Yin, Soon-Sun Hong, Ju-Hee Kang, Yong Song Gho, Jun-Kyu Suh, Ji-Kan Ryu
Int. J. Biol. Sci. 2022; 18(9): 3653-3667. doi:10.7150/ijbs.72243
[Abstract] [Full text] [PDF]


Graphic abstract

IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis
Xiaoke Huang, Jing Fang, Weiqi Lai, Yu Hu, Liang Li, Yuanyou Zhong, Shiwei Yang, Dan He, Rui Liu, Qingfeng Tang
Int. J. Biol. Sci. 2022; 18(9): 3668-3675. doi:10.7150/ijbs.68990
[Abstract] [Full text] [PDF]


Graphic abstract

Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction
Yiyang Wang, Haoming Wang, Yunyun Zhuo, Yanzhu Hu, Xiaoxiao Li, Yanqin Xu, Biemin Sun, Min Liu, Luetao Zou, Liehua Liu, Lei Luo, Chen Zhao, Pei Li, Qiang Zhou
Int. J. Biol. Sci. 2022; 18(9): 3676-3696. doi:10.7150/ijbs.70903
[Abstract] [Full text] [PDF]


Graphic abstract

Suppressing MDSC Infiltration in Tumor Microenvironment Serves as an Option for Treating Ovarian Cancer Metastasis
Yichen Li, Qian Zhang, Mandi Wu, Peidong Zhang, Liang Huang, Xiaolin Ai, Zhengnan Yang, Qiuhong Shen, Yiran Wang, Ping Wang, Shengtao Zhou, Ming-Liang He
Int. J. Biol. Sci. 2022; 18(9): 3697-3713. doi:10.7150/ijbs.70013
[Abstract] [Full text] [PDF]


Graphic abstract

Isovalerylspiramycin I suppresses non-small cell lung carcinoma growth through ROS-mediated inhibition of PI3K/AKT signaling pathway
Zeyu Liu, Moli Huang, Yue Hong, Shaoyang Wang, Yongle Xu, Cheng Zhong, Jingyuan Zhang, Zhengping Zhuang, Shan Shan, Tao Ren
Int. J. Biol. Sci. 2022; 18(9): 3714-3730. doi:10.7150/ijbs.69989
[Abstract] [Full text] [PDF]


Graphic abstract

Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest
Jinyu Shi, Li Zhou, Hui-Si Huang, Liyuan Peng, Na Xie, Edouard Nice, Li Fu, Cen Jiang, Canhua Huang
Int. J. Biol. Sci. 2022; 18(9): 3747-3761. doi:10.7150/ijbs.70679
[Abstract] [Full text] [PDF]


Graphic abstract

Establishment and Validation of an Interferon-Stimulated Genes (ISGs) Prognostic Signature in Pan-cancer Patients: A Multicenter, Real-world Study
Zheng Zhou, Yujia Zheng, Shaobo Mo, Shuofeng Li, Xinlei Zheng, Ran Wei, Tao Fan, Tianli Chen, Chu Xiao, Chunxiang Li, Jie He
Int. J. Biol. Sci. 2022; 18(9): 3762-3776. doi:10.7150/ijbs.71385
[Abstract] [Full text] [PDF]


Graphic abstract

HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway
Wu Wu, Qujin Li, Zhu Zhu, Chunming Li, Peilin Lu, Xi Zhou, Yujing Huang, Yan Liu, Menghao Wang, Jianping Gong
Int. J. Biol. Sci. 2022; 18(9): 3777-3794. doi:10.7150/ijbs.70546
[Abstract] [Full text] [PDF]


Graphic abstract

Egr1 confers protection against acetaminophen‑induced hepatotoxicity via transcriptional upregulating of Acaa2
Xiaohong Lei, Qingling Xu, Chunmin Li, Baolin Niu, Yanan Ming, Jing Li, Yingyue Tang, Xiaoyun Li, Jieting Tang, Jing Wu, Yi Ju, Lvfeng Yao, Bin Wang, Qi Miao, Wei Zhong, Yang Zhi, Lirong Xu, Chaojun Li, Xiaobo Li, Yimin Mao
Int. J. Biol. Sci. 2022; 18(9): 3800-3817. doi:10.7150/ijbs.71781
[Abstract] [Full text] [PDF]


Graphic abstract

Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer
Muhammad Jameel Mughal, Kin Iong Chan, Ravikiran Mahadevappa, Sin Wa Wong, Kit Cheng Wai, Hang Fai Kwok
Int. J. Biol. Sci. 2022; 18(9): 3827-3844. doi:10.7150/ijbs.69344
[Abstract] [Full text] [PDF]


Graphic abstract

Inhibitory role of TRIP-Br1 oncoprotein in anticancer drug-mediated programmed cell death via mitophagy activation
Samil Jung, Davaajargal Myagmarjav, Taeyeon Jo, Soonduk Lee, Songyi Han, Nguyen Thi Ngoc Quynh, Nguyen Hai Anh, Son Hai Vu, Yeongseon Choi, Myeong-Sok Lee
Int. J. Biol. Sci. 2022; 18(9): 3859-3873. doi:10.7150/ijbs.72138
[Abstract] [Full text] [PDF]


Graphic abstract

Integrative Analyses of m6A Regulators Identify that METTL3 is Associated with HPV Status and Immunosuppressive Microenvironment in HPV-related Cancers
Ruidi Yu, Ye Wei, Chao He, Ping Zhou, Hong Yang, Chang Deng, Rang Liu, Peng Wu, Qinglei Gao, Canhui Cao
Int. J. Biol. Sci. 2022; 18(9): 3874-3887. doi:10.7150/ijbs.70674
[Abstract] [Full text] [PDF]


Graphic abstract

Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation
Hang Chen, Rui Yang, Lei Xing, Bin Wang, Dawei Liu, Xiaoqiang Ou, Yumei Deng, Rong Jiang, Junxia Chen
Int. J. Biol. Sci. 2022; 18(9): 3888-3907. doi:10.7150/ijbs.72842
[Abstract] [Full text] [PDF]


Graphic abstract

Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations
Qi Lu, Yang Xu, Shanshan Li, Zeng Zhang, Jiagen Sheng, Zhenlin Zhang
Int. J. Biol. Sci. 2022; 18(9): 3908-3917. doi:10.7150/ijbs.71261
[Abstract] [Full text] [PDF]

Reviews

Graphic abstract

Role of m6A modification in female infertility and reproductive system diseases
Jinyu Chen, Yiwei Fang, Ying Xu, Haotong Sun
Int. J. Biol. Sci. 2022; 18(9): 3592-3604. doi:10.7150/ijbs.69771
[Abstract] [Full text] [PDF]


Graphic abstract

The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review
Kalthoum Tizaoui, Jae Won Yang, Keum Hwa Lee, Ji Hong Kim, Minseok Kim, Sojung Yoon, Yeonwoo Jung, Joon Beom Park, Kitae An, Hyeok Choi, Donggyu Song, HyunTaek Jung, Seongmin Ahn, Taeho Yuh, Hee Min Choi, Jae Ha Ahn, Younjuong Kim, Sanghyun Jee, Hyeongsun Lee, Soohwa Jin, Jun-Gu Kang, Bohyun Koo, Joo Yeop Lee, Kyoung Min Min, Wonseok Yoo, Hyeong Jun Rhyu, Yeonjung Yoon, Min Ho Lee, Sung Eun Kim, Jimin Hwang, Ai Koyanagi, Louis Jacob, Seoyeon Park, Jae Il Shin, Lee Smith
Int. J. Biol. Sci. 2022; 18(9): 3731-3746. doi:10.7150/ijbs.67587
[Abstract] [Full text] [PDF]


Graphic abstract

VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment
Yueshui Zhao, Sipeng Guo, Jian Deng, Jing Shen, Fukuan Du, Xu Wu, Yu Chen, Mingxing Li, Meijuan Chen, Xiaobing Li, Wanping Li, Li Gu, Yuhong Sun, Qinglian Wen, Jing Li, Zhangang Xiao
Int. J. Biol. Sci. 2022; 18(9): 3845-3858. doi:10.7150/ijbs.70958
[Abstract] [Full text] [PDF]

Errata

BRD4 Inhibitor AZD5153 Suppresses the Proliferation of Colorectal Cancer Cells and Sensitizes the Anticancer Effect of PARP Inhibitor: Erratum
Peng Zhang, Ruidong Li, Hua Xiao, Weizhen Liu, Xiangyu Zeng, Genchen Xie, Wenchang Yang, Liang Shi, Yuping Yin, Kaixiong Tao
Int. J. Biol. Sci. 2022; 18(9): 3795-3797. doi:10.7150/ijbs.73868
[Abstract] [Full text] [PDF]


EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer: Erratum
Qiang Zhou, Song Chen, Mengxin Lu, Yongwen Luo, Gang Wang, Yu Xiao, Lingao Ju, Xinghuan Wang
Int. J. Biol. Sci. 2022; 18(9): 3798-3799. doi:10.7150/ijbs.75156
[Abstract] [Full text] [PDF]